In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 12 ( 2020-12-11), p. e0243942-
Abstract:
Some children are more susceptible to viral and bacterial respiratory infections in the first few years of life than others. However, the factors contributing to this susceptibility are incompletely understood. In a retrospective analysis of clinical samples collected from a prospectively-enrolled cohort of 358 children we sought associations between physician-attended illness visits and bacterial colonization in the first five years of life. A subset of children was identified by unsupervised clustering analysis as infection and allergy prone (IAP). Several respiratory infection- and allergy-mediated illnesses co-occurred at higher rates in IAP children, while the rates of other illnesses were not significantly different between the groups. Analyses of nasopharyngeal (NP) pathobionts and microbiota commensals showed that early age of first colonization with pathobionts Streptococcus pneumonia , non-typeable Haemophilus influenzae , and Moraxella catarrhalis was associated with IAP children, and particularly Moraxella abundance was negatively associated with NP microbiome diversity. We conclude that mucosal pathobiont exposures in early life can influence susceptibility to respiratory illnesses in children.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0243942
DOI:
10.1371/journal.pone.0243942.g001
DOI:
10.1371/journal.pone.0243942.g002
DOI:
10.1371/journal.pone.0243942.g003
DOI:
10.1371/journal.pone.0243942.g004
DOI:
10.1371/journal.pone.0243942.t001
DOI:
10.1371/journal.pone.0243942.t002
DOI:
10.1371/journal.pone.0243942.t003
DOI:
10.1371/journal.pone.0243942.s001
DOI:
10.1371/journal.pone.0243942.s002
DOI:
10.1371/journal.pone.0243942.s003
DOI:
10.1371/journal.pone.0243942.s004
DOI:
10.1371/journal.pone.0243942.s005
DOI:
10.1371/journal.pone.0243942.s006
DOI:
10.1371/journal.pone.0243942.s007
DOI:
10.1371/journal.pone.0243942.s008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
Permalink