In:
Neuropsychobiology, S. Karger AG, Vol. 44, No. 1 ( 2001), p. 36-40
Abstract:
Clozapine has superior effects in treating negative symptoms of schizophrenia and causes less extrapyramidal side effects than traditional antipsychotics. In this study, we investigated the effects of acute and long-term clozapine administration on [ 〈 sup 〉 14 〈 /sup 〉 C]2-deoxyglucose uptake (2-DG uptake) in rats, as measured using the [ 〈 sup 〉 14 〈 /sup 〉 C]2-deoxy- 〈 i 〉 D 〈 /i 〉 -glucose method. The 2-DG uptake was reduced in fewer regions after chronic clozapine (46%) than after acute clozapine (97%). After chronic clozapine treatment, the 2-DG uptake was reduced in the shell, but not the core, of the nucleus accumbens. In addition, long-term clozapine treatment remained affecting 2-DG uptake in several regions of the extrapyramidal system and the thalamus. The pattern of 2-DG uptake changes after long-term clozapine administration may provide information for the regions related to the therapeutic effect of clozapine.
Type of Medium:
Online Resource
ISSN:
0302-282X
,
1423-0224
Language:
English
Publisher:
S. Karger AG
Publication Date:
2001
detail.hit.zdb_id:
1483094-2
SSG:
5,2
SSG:
15,3
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