In:
Clinical Endocrinology, Wiley, Vol. 82, No. 2 ( 2015-02), p. 229-233
Abstract:
Diabetic nephropathy ( DN ) is a common complication in diabetics. Recent evidence suggests that neutrophil–lymphocyte ratio ( NLR ) affects the development and acceleration of some diabetic complications. Scholars have rarely investigated the relationship between DN and NLR . This study aims to evaluate the relationship between DN and NLR and estimate whether or not NLR is a reliable marker for early‐stage DN . Patients and methods The study included 253 patients with type 2 diabetes mellitus, 115 of whom have early‐stage DN . The control group was composed of 210 healthy age‐ and sex‐matched subjects. Results The NLR values of the patients with diabetes were significantly higher than those of the healthy controls ( P 〈 0·001), and the NLR values of the patients with early‐stage DN were higher than those of the patients without DN ( P 〈 0·001). Logistic regression analysis showed that the risk predictors of DN include NLR , creatinine, total cholesterol, systolic blood pressure, HbA1c and insulin resistance. NLR ( P = 0·004, EXP (B) = 2·088, 95% CI = 1·271–3·429) levels positively correlated with DN . The DN odds ratio increased by a factor of 2·088 (95% CI , 1·271–3·429) for every one unit increase in NLR . Conclusions Increased NLR was significantly associated with DN , and high NLR values may be a reliable predictive marker of early‐stage DN .
Type of Medium:
Online Resource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2015.82.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
121745-8
detail.hit.zdb_id:
2004597-9
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