In:
Advanced Synthesis & Catalysis, Wiley, Vol. 359, No. 5 ( 2017-03-06), p. 772-778
Abstract:
A direct C‐5–H arylation of 3‐substituted 1,2,4‐oxadiazoles with aryl iodides in the presence of a palladium catalyst and silver acetate is reported. This method provides a rapid, reliable way to obtain versatile 3,5‐diaryl‐1,2,4‐oxadiazole derivatives, which are common moieties of many biologically active molecules. The synthetic applications of this novel method have been demonstrated in the concise syntheses of Ataluren and a potent RET inhibitor Yhhu251. magnified image
Type of Medium:
Online Resource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.201600913
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2041384-1
detail.hit.zdb_id:
2033084-4
Permalink