In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 13, No. 583 ( 2021-03-03)
Abstract:
Tumor cells exploit signaling pathways involved in cell survival, proliferation, and migration to promote tumor growth and metastasis. Here, Wu et al . investigated one such pathway, interleukin-17 receptor B (IL-17RB) signaling, in the context of pancreatic cancer. The authors found that IL-17RB signaling in human pancreatic cancer specimens was associated with poorer outcomes, but signaling could be blocked in vitro using a peptide derived from the loop region of IL-17B, the ligand for IL-17RB. Further, IL-17B loop peptide treatment controlled tumor burden and extended survival in two mouse models of pancreatic cancer. These findings suggest that IL-17B loop peptide may be a therapeutic option for pancreatic cancer.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abc2823
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2021
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