In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 7 ( 2023-7-12), p. e0288380-
Abstract:
It has been shown that exercise has a direct impact on tumor growth along with functional improvement. Previous studies have shown that exercise decreases the risk of cancer recurrence across various types of cancer. It was indicated that exercise stimulates the immune system to fight cancer. Previous study demonstrated that pulsed-wave ultrasound hyperthermia (pUH) combined with PEGylated liposomal doxorubicin (PLD) and chloroquine (CQ) inhibits 4T1 tumors growth and delays their recurrence. In this study, we investigated if the combinatorial treatment with high-intensity interval training (HIIT) combined with pUH-enhanced PLD delivery and CQ improved the outcome. The mouse experiment composed of three groups, HIIT+PLD+pUH+CQ group, PLD+pUH+CQ group, and the control group. HIIT+PLD+pUH+CQ group received 6 weeks of HIIT (15 min per day, 5 days per week) before 4T1 tumor implantation. Seven days later, they received therapy with PLD (10 mg/kg) + pUH (3 MHz, 50% duty cycle, 0.65 W/cm 2 , 15min) + CQ (50 mg/kg daily). Results showed that HIIT+PLD+pUH+CQ significantly reduced the tumor volumes and brought about longer survival of tumor-bearing mice than PLD+pUH+CQ did. Blood cell components were analyzed and showed that neutrophil and reticulocytes decreased while lymphocytes increased after exercise.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0288380
DOI:
10.1371/journal.pone.0288380.g001
DOI:
10.1371/journal.pone.0288380.g002
DOI:
10.1371/journal.pone.0288380.g003
DOI:
10.1371/journal.pone.0288380.g004
DOI:
10.1371/journal.pone.0288380.g005
DOI:
10.1371/journal.pone.0288380.g006
DOI:
10.1371/journal.pone.0288380.g007
DOI:
10.1371/journal.pone.0288380.t001
DOI:
10.1371/journal.pone.0288380.s001
DOI:
10.1371/journal.pone.0288380.s002
DOI:
10.1371/journal.pone.0288380.s003
DOI:
10.1371/journal.pone.0288380.r001
DOI:
10.1371/journal.pone.0288380.r002
DOI:
10.1371/journal.pone.0288380.r003
DOI:
10.1371/journal.pone.0288380.r004
DOI:
10.1371/journal.pone.0288380.r005
DOI:
10.1371/journal.pone.0288380.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
Permalink