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  • 1
    Online Resource
    Online Resource
    Tc-99m TRODAT-1 SPECT is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease
    MDPI AG ; 2020
    In:  Journal of Clinical Medicine Vol. 9, No. 3 ( 2020-03-24), p. 889-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 9, No. 3 ( 2020-03-24), p. 889-
    Abstract: Rationales: Restless leg syndrome (RLS) is a common complication in patients with end-stage renal disease (ESRD). However, there is a lack of biomarkers linking uremic RLS to dopaminergic neurons. Previous studies demonstrated that Tc-99m TRODAT-1 SPECT was a biomarker for RLS but the correlation between the physiologic parameter was lacking. Methods: Overall, 32 patients were enrolled in the study and divided into the following 3 groups: (1) control (n = 13), (2) ESRD without RLS (n = 8) and (3) ESRD with RLS (n = 11). All patients had a clinical diagnosis of RLS and received Tc-99m TRODAT-1 SPECT. A subgroup analysis was performed to compare differences between the control and ESRD with RLS groups. Tc-99m TRODAT-1 SPECT was performed and activities in the striatum and occipital areas were measured using manually delineated regions of interest (ROIs) by an experienced nuclear medicine radiologist who was blinded to clinical data. Results: The total ratio of Tc-99m TRODAT SPECT was lower in the ESRD with RLS group (p = 0.046). The uptake ratio of TRODAT negatively correlated with serum parathyroid hormone (r = −0.577, p = 0.015) and ferritin (r = −0.464, p = 0.039) concentrations. However, the uptake positively correlated with the hemoglobin concentration (r = 0.531, p = 0.011). The sensitivity and specificity of the total TRODAT ratio for predicting RLS in the overall population were 95.0% and 67.7%, respectively, at a cutoff value of 0.980 (area under the curve of receiver operating characteristic curve was 0.767, p = 0.024). Conclusion: In patients with ESRD and RLS, Tc-99m TRODAT might be a potential biomarker. Dysregulated hemoglobin, serum parathyroid hormone and serum ferritin concentrations might influence the uptake of the TRODAT ratio.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm9030889
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2662592-1
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  • 2
    Online Resource
    Online Resource
    Effects of Parental Involvement in a Preschool-Based Eye Health Intervention Regarding Children’s Screen Use in China
    MDPI AG ; 2021
    In:  International Journal of Environmental Research and Public Health Vol. 18, No. 21 ( 2021-10-28), p. 11330-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 18, No. 21 ( 2021-10-28), p. 11330-
    Abstract: In this digital era, young children spend a considerable amount of time looking at telephone, tablet, computer and television screens. However, preventative eye health behavior education could help avoid and relieve asthenopia. The effects of parental influence on their children’s eye health behavior through the preschool eye health education intervention program were examined. The Health Belief Model was used to develop parental involvement strategy and eye health curriculum. The study was conducted in a large public preschool with five branches in Beijing, China. A total of 248 parent–child pairs participated in the baseline and follow-up surveys, of which 129 were in the intervention group and 119 were in the comparison group. The generalized estimating equation analysis results indicated that parental involvement in preschool-based eye health intervention on screen uses had positive influence on parents’ eye health knowledge, cues to action, and parenting efficacy. The intervention program also had positive effects on the increasing level of children’s eye health knowledge, beliefs, cues to action, self-efficacy, and behaviors. The results supported the implementation of a preschool-based eye health intervention program with parental involvement, which could potentially enhance children’s and parents’ eye health beliefs and practices.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph182111330
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2175195-X
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  • 3
    Online Resource
    Online Resource
    Low-defect-density WS2 by hydroxide vapor phase deposition
    Springer Science and Business Media LLC ; 2022
    In:  Nature Communications Vol. 13, No. 1 ( 2022-07-18)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-07-18)
    Abstract: Two-dimensional (2D) semiconducting monolayers such as transition metal dichalcogenides (TMDs) are promising channel materials to extend Moore’s Law in advanced electronics. Synthetic TMD layers from chemical vapor deposition (CVD) are scalable for fabrication but notorious for their high defect densities. Therefore, innovative endeavors on growth reaction to enhance their quality are urgently needed. Here, we report that the hydroxide W species, an extremely pure vapor phase metal precursor form, is very efficient for sulfurization, leading to about one order of magnitude lower defect density compared to those from conventional CVD methods. The field-effect transistor (FET) devices based on the proposed growth reach a peak electron mobility ~200 cm 2 /Vs (~800 cm 2 /Vs) at room temperature (15 K), comparable to those from exfoliated flakes. The FET device with a channel length of 100 nm displays a high on-state current of ~400 µA/µm, encouraging the industrialization of 2D materials.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/s41467-022-31886-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2553671-0
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  • 4
    Online Resource
    Online Resource
    The BH3 domain of Bax is essential for regulating its solubility and mitochondrial targeting
    Wiley ; 2006
    In:  The FASEB Journal Vol. 20, No. 4 ( 2006-03)
    Details
    In: The FASEB Journal, Wiley, Vol. 20, No. 4 ( 2006-03)
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v20.4
    DOI: 10.1096/fasebj.20.4.A118-c
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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    Online Resource
  • 5
    Online Resource
    Online Resource
    C6‐pyridinium ceramide induces Bax translocation from cytosol to mitochondria in MCF‐7 cells via a new signaling pathway
    Wiley ; 2006
    In:  The FASEB Journal Vol. 20, No. 4 ( 2006-03)
    Details
    In: The FASEB Journal, Wiley, Vol. 20, No. 4 ( 2006-03)
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v20.4
    DOI: 10.1096/fasebj.20.4.A507-c
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    The matrix (M) protein of newcastle disease virus binds to human bax through its BH3 domain
    Springer Science and Business Media LLC ; 2011
    In:  Virology Journal Vol. 8, No. 1 ( 2011-12)
    Details
    In: Virology Journal, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2011-12)
    Abstract: The underlying mechanisms by which Newcastle disease virus (NDV) kills cancer cells are still unclear. Recent discoveries have shown that many viruses contain Bcl-2 homology-like domains which enabled their interaction with Bcl-2 family members, and thereby accounting for their virulence and pathogenicity. Alignment of the protein sequences of Malaysian strain of NDV, known as AF2240, with those from members of the human Bcl-2 family showed many similar regions; most notably we found that its matrix (AF2240-M) protein, large (AF2240-L) protein and fusion (AF2240-F) protein all contain BH3-like regions. In addition, there are BH1-like domains in these proteins, where AF2240-F and Mcl-1 share 55% identity within this region. To further investigate our hypothesis that the presence of the BH3-like domains in these proteins may convey cytotoxicity, AF2240-M and AF2240-F genes were cloned into pFLAG and pEGFP.N2 vectors and transfected into HeLa cells. The expression of these constructs promoted cell death. As shown by flow cytometry, AF2240-M protein with deleted BH3-like region showed five-fold decrease in apoptosis. Moreover, the construct containing the N-terminal of AF2240-M showed nearly the same cell death rate as to that of the full-length protein, strongly suggesting that the BH3-like domain within this protein participates in promoting cell death. Moreover, AF2240-M transfection promoted Bax redistribution to mitochondria. Therefore, to determine whether there is any direct interaction between NDV viral proteins with some members of the Bcl-2 family, various constructs were co-transfected into HeLa cells. Co-immunoprecipitation trials showed that the AF2240-M indeed directly interacted with Bax protein via its BH3-domain, as the mutant proteins failed to interact with Bax. AF2240-F failed to interact with any of the tested proteins, although Bcl-XL slowed down the rate of cell death caused by this construct by nearly five-fold. In a parallel experiment, the level of expression of endogenous Bax and Bcl-2 after infection of HeLa cells with NDV was assessed by qRT-PCR, but no statistically significant change was observed. Consequently, the Bax/Bcl-2 ratio at the mRNA level did not alter. Overall, our study has shed additional light into the mechanisms by which NDV induces apoptosis.
    Type of Medium: Online Resource
    ISSN: 1743-422X
    URL: Article
    DOI: 10.1186/1743-422X-8-385
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 2160640-7
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  • 7
    Online Resource
    Online Resource
    Understanding Pro-Environmental Behavior of Citizen Science: An Exploratory Study of the Bird Survey in Taoyuan’s Farm Ponds Project
    MDPI AG ; 2021
    In:  Sustainability Vol. 13, No. 9 ( 2021-05-03), p. 5126-
    Details
    In: Sustainability, MDPI AG, Vol. 13, No. 9 ( 2021-05-03), p. 5126-
    Abstract: This exploratory study aims to fill the gap by adopting Hirose’s two-phase decision-making model with the theory of social networks to explore the environmentally friendly attitudes and environmental behavioral intentions toward pro-environmental behaviors of the citizen scientists who participated in the Bird Survey in Taoyuan’s Farm Ponds Project. The Bird Survey in Taoyuan’s Farm Ponds Project is a systematic citizen science project founded in 2003 with the aim to identify existing and potential irrigation ponds that are important to creating waterbird refuges to secure habitats for wintering waterbirds in anthropogenically influenced areas. The participation in this project itself can be considered as a form of pro-environmental behavior. A total of 24 in-depth semi-structured interviews were conducted with participants of the Bird Survey in Taoyuan’s Farm Ponds Project. Qualitative data showed that participants mentioned six variables (i.e., perceived seriousness, ascription of responsibility, belief in the effectiveness, feasibility evaluation, cost–benefit evaluation, and social norms evaluation) of the two-phase decision-making model in relation to environmentally friendly attitudes and environmental behavioral intention. Findings also revealed three key variables (i.e., social networks, learning and growth, and belonging and contribution) in the theory of social networks that are associated with environmentally friendly attitudes and environmental behavioral intention. Based on the findings, it is proposed that the social needs variables are incorporated as an extension to the two-phase decision-making model to offer a more comprehensive explanation of pro-environmental behavior.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su13095126
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2518383-7
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  • 8
    Online Resource
    Online Resource
    Preparation and characterization of interconnected carbon nanofibers
    SAGE Publications ; 2015
    In:  Textile Research Journal Vol. 85, No. 1 ( 2015-01), p. 3-12
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 85, No. 1 ( 2015-01), p. 3-12
    Abstract: A strategy to prepare interconnected carbon nanofibers using an electrospinning technique is proposed. This strategy lies in the addition of poly(acrylonitrile-co-butadiene (PAN-co-PB) copolymer in a precursor solution composed of polyacrylonitrile (PAN) and N,N-dimethylformamide. During pyrolysis, PB decomposed, softening the fibers and creating the possibility of fiber–fiber connection. The fiber diameter decreased with an increase in the PAN-co-PB content. Further addition of PAN-co-PB caused the fusion of neighboring fibers, which enlarged the fiber diameter and decreased the specific surface area of fibers. The microcrystallite sizes of carbon nanofibers depended on the PAN-co-PB content; and the addition of PAN-co-PB promoted the development of ordered graphite crystallites. The interconnected carbon nanofibers exhibited an electrical conductivity four times larger than that of the nanofibers with a uniform separated fibrous structure. The purpose of this work is to prepare carbon nanofiber mats with good electrical conductivity and well-controlled morphology for further use as energy-associated devices and catalyst supports.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/0040517514542142
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2209596-2
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  • 9
    Online Resource
    Online Resource
    Bax translocates from cytosol to mitochondria in cardiac cells during apoptosis: development of a GFP-Bax-stable H9c2 cell line for apoptosis analysis
    American Physiological Society ; 2005
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 289, No. 1 ( 2005-07), p. H477-H487
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 289, No. 1 ( 2005-07), p. H477-H487
    Abstract: The proapoptotic protein Bax plays an important role in cardiomyocytic cell death. Ablation of this protein has been shown to diminish cardiac damage in Bax-knockout mice during ischemia-reperfusion. Presently, studies of Bax-mediated cardiac cell death examined primarily the expression levels of Bax and its prosurvival factor Bcl-2 rather than the localization of this protein, which dictates its function. Using immunofluorescence labeling, we have shown that in neonatal rat cardiomyocytes and in H9c2 cardiomyoblasts, Bax translocates from cytosol to mitochondria upon the induction of apoptosis by hypoxia-reoxygenation-serum withdrawal and by the presence of the free-radical inducer menadione. Also, we found that Bax translocation to mitochondria was associated with the exposure of an NH 2 -terminal epitope, and that this translocation could be partially blocked by the prosurvival factors Bcl-2 and Bcl-X L . To visualize the translocation of Bax in living cells, we have developed an H9c2 cell line that stably expresses green fluorescent protein (GFP)-tagged Bax. This cell line has GFP-Bax localized primarily in the cytosol in the absence of apoptotic inducers. Upon induction of apoptosis by a number of stimuli, including menadione, staurosporine, sodium nitroprusside, and hypoxia-reoxygenation-serum withdrawal, we could observe the translocation of Bax from cytosol to mitochondria. This translocation was not affected by retinoic acid-induced differentiation of H9c2 cells. Additionally, this translocation was associated with loss of mitochondrial membrane potential, release of cytochrome c, and fragmentation of nuclei. Finally, using a tetramethylrhodamine-based dye, we have shown that a rapid screening process based on the loss of mitochondrial membrane potential could be developed to monitor GFP-Bax translocation to mitochondria. Overall, the GFP-Bax-stable H9c2 cell line that we have developed represents a unique tool for examining Bax-mediated apoptosis, and it could be of great importance in screening therapeutic compounds that could block Bax translocation to mitochondria to attenuate apoptosis.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.00879.2004
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2005
    detail.hit.zdb_id: 1477308-9
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells
    Informa UK Limited ; 2009
    In:  Autophagy Vol. 5, No. 4 ( 2009-05-16), p. 451-460
    Details
    In: Autophagy, Informa UK Limited, Vol. 5, No. 4 ( 2009-05-16), p. 451-460
    Type of Medium: Online Resource
    ISSN: 1554-8627 , 1554-8635
    URL: Article
    DOI: 10.4161/auto.5.4.7666
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2009
    detail.hit.zdb_id: 2262043-6
    SSG: 12
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