In:
Histopathology, Wiley, Vol. 64, No. 5 ( 2014-04), p. 713-721
Abstract:
In order to determine whether the expression of tumour‐associated carbohydrate antigens (Tn/sTn) and a representative inflammation marker, nuclear factor‐κB (NF‐κB), is associated with the invasiveness of oral squamous cell carcinoma ( OSCC ), this study has attempted to investigate the correlation of the aforementioned markers with the well‐established invasive pattern grading score (IPGS) and clinicopathological parameters. Methods and results Specimens from 143 OSCC patients with classified clinicopathological parameters and IPGS were stained immunohistochemically using anti‐Tn, sTn and NF‐κB antibodies. Our results showed that the expression of both Tn and NF ‐κB was correlated positively with staging ( P = 0.036; P = 0.015), recurrence ( P 〈 0.001; P 〈 0.001) and distant metastasis ( P = 0.005; P = 0.009), as well as with IPGS , while the expression of sTn was correlated inversely. In addition, poor survival was associated with overexpression of Tn and NF‐κB but not with expression of sTn. Conclusions Our results indicate that a reciprocal relationship between Tn and sTn expression may serve as a reliable indicator for OSCC prognostic evaluation. In addition, expression of Tn rather than sTn may play an important role in deeply invasive OSCC via regulation of NF‐κB signalling.
Type of Medium:
Online Resource
ISSN:
0309-0167
,
1365-2559
DOI:
10.1111/his.2014.64.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2006447-0
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