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  • 1
    Online Resource
    Online Resource
    Elsevier BV ; 2020
    In:  SSRN Electronic Journal
    In: SSRN Electronic Journal, Elsevier BV
    Type of Medium: Online Resource
    ISSN: 1556-5068
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
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  • 2
    Online Resource
    Online Resource
    Medip Academy ; 2023
    In:  International Journal of Basic & Clinical Pharmacology Vol. 12, No. 5 ( 2023-08-25), p. 766-770
    In: International Journal of Basic & Clinical Pharmacology, Medip Academy, Vol. 12, No. 5 ( 2023-08-25), p. 766-770
    Abstract: Simulation-based education has become an integral part of education and training in high-risk professions and disciplines such as aviation, aerospace, military, nuclear power plants, medicine and healthcare. In the last decade, medical simulation has globally emerged as a powerful instructional technique across various specialties and disciplines. Despite its increasing popularity and various advantages, simulation-based medical education (SBME) poses a unique challenge, that is, realism. This is where the concept of fiction contract or suspension of disbelief comes into the picture. In this article we provide an overview of fiction contract in SBME including how can it be effectively addressed during training.
    Type of Medium: Online Resource
    ISSN: 2279-0780 , 2319-2003
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2023
    detail.hit.zdb_id: 2681376-2
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Elsevier BV ; 2022
    In:  Materials Today: Proceedings Vol. 48 ( 2022), p. 1320-1324
    In: Materials Today: Proceedings, Elsevier BV, Vol. 48 ( 2022), p. 1320-1324
    Type of Medium: Online Resource
    ISSN: 2214-7853
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2797693-2
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  • 4
    Online Resource
    Online Resource
    International Journal of Pharma and Bio Sciences ; 2022
    In:  International Journal of pharma and Bio Sciences Vol. 13, No. 2 ( 2022-05-06)
    In: International Journal of pharma and Bio Sciences, International Journal of Pharma and Bio Sciences, Vol. 13, No. 2 ( 2022-05-06)
    Abstract: Risperidone is a second-generation antipsychotic drug that exhibits D2, 5-HT2A, α1, α2, and H1 receptor affinity. Patients suffering from Schizophrenia are prescribed with this drug. It is mostly used for controlling the overactivity of the central mesolimbic and mesocortical pathways of the patients. According to the studies conducted it has been found that Risperidone possesses teratogenic actions on various model organisms. Consumption of this antipsychotic drug is not only associated with behavioural changes but also with physical alterations. It increases the risk by elevating nitric oxide levels and activating macrophages which leads to apoptotic events in the viable cells. Furthermore, it has been established that Risperidone toxicity caused due to overdose induces neurological as well as cardiovascular defects. Risperidone has the ability to cross the placental barrier and reach the foetal bloodstream intuitively. In addition, Risperidone also gets distributed in the milk of a lactating mother leading to undesirable changes in the breastfed babies. Here in this study, we have shown that Gallus gallus domesticus embryos (HH 23-26) treated with a minimum dose of Risperidone (1000 ppm) altered the protein and enzyme biochemistry with respect to total protein content, alkaline phosphatase (ALP), and Acetylcholinesterase levels. Cell viability studies conducted using flowcytometry have indicated its possible role in the induction of apoptosis as well as necrosis in a developing chick embryo. The present study provides insight into the effects of Risperidone that it may possess on gestating and lactating women. The study also explains the teratogenic potential of Risperidone on target and non-target organisms.
    Type of Medium: Online Resource
    ISSN: 0975-6299
    URL: Issue
    Language: Unknown
    Publisher: International Journal of Pharma and Bio Sciences
    Publication Date: 2022
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Wiley ; 2022
    In:  Immunology Vol. 165, No. 1 ( 2022-01), p. 122-140
    In: Immunology, Wiley, Vol. 165, No. 1 ( 2022-01), p. 122-140
    Abstract: Haemoglobin (Hb) has well‐documented inflammatory effects and is normally efficiently scavenged; clearance mechanisms can be overwhelmed during erythrocyte lysis. Whether Hb is preferentially inflammatory in lupus and triggers broad anti‐self responses was assessed. Peripheral blood mononuclear cells (PBMCs) derived from SLE patients secreted higher levels of lupus‐associated inflammatory cytokines when incubated with human Hb than did PBMCs derived from healthy donors, an effect negated by haptoglobin. Ferric murine Hb triggered the preferential release of lupus‐associated cytokines from splenocytes, B cells, CD4 T cells, CD8 T cells and plasmacytoid dendritic cells isolated from ageing, lupus‐prone NZM2410 mice, and also had mitogenic effects on B cells. Pull‐downs, followed by mass spectrometry, revealed interactions of Hb with several lupus‐associated autoantigens; co‐incubation of ferric Hb with apoptotic blebs (structures that contain packaged autoantigens) revealed synergies—in terms of cytokine release and autoantibody production in vitro—that were also restricted to the lupus genotype. Murine ferric Hb activated multiple signalling pathways and, in combination with apoptotic blebs, preferentially triggered MAP kinase signalling specifically in splenocytes isolated from lupus‐prone mice. Infusion of murine ferric Hb into lupus‐prone mice led to enhanced release of lupus‐associated cytokines, the generation of a spectrum of autoantibodies and enhanced‐onset glomerulosclerosis. Given that the biased recognition of ferric Hb in a lupus milieu, possibly in concert with lupus‐associated autoantigens, triggers inflammatory responses and the generation of lupus‐associated cytokines, and also stimulates the generation of potentially pathogenic lupus‐associated autoantibodies, neutralization of Hb could have beneficial effects.
    Type of Medium: Online Resource
    ISSN: 0019-2805 , 1365-2567
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2006481-0
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  • 6
    Online Resource
    Online Resource
    IOP Publishing ; 2022
    In:  IOP Conference Series: Materials Science and Engineering Vol. 1272, No. 1 ( 2022-12-01), p. 012020-
    In: IOP Conference Series: Materials Science and Engineering, IOP Publishing, Vol. 1272, No. 1 ( 2022-12-01), p. 012020-
    Abstract: Inspired by humpback whale flippers, this study presents the effect of leading-edge tubercles on the wind turbine blade. Force models for lift and drag are developed on the blade which have an important role in the wind turbine performance. The study compares the CFD simulation of fluid flow over blade with leading edge tubercles and the conventional blade. Present work also covers strength and random vibration analysis for both the blades. Furthermore, different tubercle blades have been compared for lift and drag coefficients by varying tubercle amplitude. Structural analysis shows tubercled blade is suitable from structural and strength point view. In tubercled blade overall lift to drag-coefficient ratio increased up to 8.5, whereas in conventional this ratio is about 1.7 which is found to be very low. This ratio clearly indicates that in the presence of tubercles on the blade, performance improving even in lower wind speed areas. Overall tubercled blade found to be more suitable for modern wind turbines.
    Type of Medium: Online Resource
    ISSN: 1757-8981 , 1757-899X
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2506501-4
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  • 7
    Online Resource
    Online Resource
    Emerald ; 2022
    In:  Journal of Advances in Management Research Vol. 19, No. 2 ( 2022-04-01), p. 161-197
    In: Journal of Advances in Management Research, Emerald, Vol. 19, No. 2 ( 2022-04-01), p. 161-197
    Abstract: The purpose of this study is to analyse various risks associated with third-party logistics (3PL) in the coffee supply chain and to present a framework that computes the influence of these risks on the critical success factors of the coffee supply chain. Design/methodology/approach The risks have been identified through a comprehensive literature review and validation by industry experts. The paper utilises an interpretive structural modelling (ISM) methodology for developing a hierarchical relationship among the CSFs. Furthermore, fuzzy MICMAC analysis is carried out to categorise these CSFs based on their driving power and dependence value. The fuzzy technique for order preferences by the similarity of an ideal solution (fuzzy-TOPSIS) approach has been applied to prioritise the risks associated with 3PL based on their ability to influence the CSFs of the coffee SC. Furthermore, we performed a sensitivity analysis to analyse the stability of the results obtained in this study. Findings This study illustrates ten risks associated with 3PL and five CSFs in the coffee supply chain. The analysis revealed that coffee enterprises need to develop a balanced pricing strategy to ensure a sustainable competitive advantage, whereas the lack of direct customer communication is the most dominant 3PL risk affecting the CSFs. Practical implications This research provides coffee enterprises with a generalised framework with set parameters that can be used to attain a successful coffee supply chain in any developing nation. Originality/value The study contributes to the literature by being the first kind of study, which has used fuzzy ISM-MICMAC to analyse the CSFs of the coffee supply chain and fuzzy-TOPSIS for analysing the impact of various risks associated with the 3PL in the coffee supply chain. Thus, this work can be considered a benchmark for future research and advancement in the coffee business field.
    Type of Medium: Online Resource
    ISSN: 0972-7981
    Language: English
    Publisher: Emerald
    Publication Date: 2022
    detail.hit.zdb_id: 2511485-2
    SSG: 3,2
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  • 8
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Annals of Medicine and Surgery Vol. 70 ( 2021-10), p. 102878-
    In: Annals of Medicine and Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 70 ( 2021-10), p. 102878-
    Type of Medium: Online Resource
    ISSN: 2049-0801
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2745440-X
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  • 9
    Online Resource
    Online Resource
    British Association of Physicians of Indian Origin ; 2020
    In:  The Physician Vol. 6, No. 3 ( 2020-10-01)
    In: The Physician, British Association of Physicians of Indian Origin, Vol. 6, No. 3 ( 2020-10-01)
    Abstract: Poster presented at Forum for Interdisciplinary Research in Medicine, Science & Technology Conference, Moscow 2020 Peer reviewed by JS Bamrah, Ananthakrishnan Raghuraman, Soumit Dasgupta & Jyothi Srinivasan
    Type of Medium: Online Resource
    ISSN: 2732-5148 , 2732-513X
    URL: Issue
    Language: Unknown
    Publisher: British Association of Physicians of Indian Origin
    Publication Date: 2020
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  • 10
    Online Resource
    Online Resource
    Phytochemistry and Ayurveda Society ; 2021
    In:  Universities' Journal of Phytochemistry and Ayurvedic Heights Vol. 2, No. 31 ( 2021-12-6), p. 17-17
    In: Universities' Journal of Phytochemistry and Ayurvedic Heights, Phytochemistry and Ayurveda Society, Vol. 2, No. 31 ( 2021-12-6), p. 17-17
    Abstract: Abstract-India has a vast diversity of herbs. Around 3,000 years before, these herbs were acknowledged and use as medicinal plants and helpful for treating people. New scientific research has established that some plants and herbs have presence of many active compounds and possess specific pharmacological properties. Aloe vera (ghritkumari) and Piper nigrum (black pepper or maricha) are the oldest plants which are used as a medicinal herb as well as in household. Aloe vera or Ghritkumari species are currently used by cosmetic and pharmaceutical industries. Aloe vera has antibacterial, antiviral, and antiseptic properties which help to treat skin-related problems. Piper nigrum is a species that is used in various medications since very old times. They have also been used as domestic medicine against various infections, a quality attributable to the existence of certain chemical moieties in them. Physicochemical analysis and bioactive compound evaluation of the medicinal plants in essence ofAloe veraandPiper nigrum was undertaken in this study.In physicochemical analysis of aloe vera, many parameters were tested against pulp extract and leave extract (i.e., pulp and leave); parameters are color, odour, taste, total solid, total ash value, total dissolved solid, specific gravity, PH, refractive index. For aloin content evaluation, High-Performance Layer Chromatography techniques were used in the Aloe vera plant. In physicochemical analysis, many standardization parameters like alcohol soluble extractive values, water-soluble extractive values, loss on drying, total ash value, acid insoluble ash and total ash value of P. nigrum fruits were analysed. For phytochemical screening, following a 6-stage extraction process is performed, the extracts collected fromP.nigrum were exposed to a number of preliminary biochemical and phytochemical tests. The presence of tannins, saponins, terpenoids, flavonoids, and alkaloids wastested in the chloroform and aqueous extract which is used in the following investigation. However, from the aggregation of all our results, we concluded that the presence of these phytochemicals and bioactive component in these medicinal plants indicates potential therapeutic properties for welfare of humans.
    Type of Medium: Online Resource
    ISSN: 0973-3507
    URL: Issue
    Language: Unknown
    Publisher: Phytochemistry and Ayurveda Society
    Publication Date: 2021
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