In:
Acta Medica (Hradec Kralove, Czech Republic), Charles University in Prague, Karolinum Press, Vol. 48, No. 2 ( 2005), p. 81-86
Abstract:
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6) were found to be more efficacious reactivators of sarin and VX-inhibited acetylcholinesterase than pralidoxime and obidoxime. On the other hand, their potency to reactivate tabun-inhibited acetylcholinesterase is very low and does not reach the reactivating efficacy of obidoxime. In the case of cyclosarin, the oxime HI-6 was only found to be able to sufficiently reactivate cyclosarin-inhibited acetylcholinesterase in vitro. 3. Thus, the oxime HLö-7 does not seem to be more efficacious reactivator of nerve agent-inhibited acetylcholinesterase than HI-6 according to in vitro evaluation of their reactivation potency and, therefore, it is not more suitable to be introduced for antidotal treatment of nerve agent-exposed people than HI-6.
Type of Medium:
Online Resource
ISSN:
1211-4286
,
1805-9694
DOI:
10.14712/18059694.2018.36
Language:
English
Publisher:
Charles University in Prague, Karolinum Press
Publication Date:
2005
detail.hit.zdb_id:
2002210-4
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