In:
BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
Abstract:
The pharmacokinetics of marbofloxacin in pigs after intravenous (i.v.), intramuscular (i.m.), and peroral (p.o.) administration and pharmacokinetic/pharmacodynamic indices of this drug against Korean local isolates of Actinobacillus pleuropneumoniae were determined in this study. Marbofloxacin (2.50 mg/kg of body weight) was administered, and blood samples were collected with designated time intervals. Plasma-extracted marbofloxacin was injected into the LC-MS/MS system. The in vitro and ex vivo antibacterial activities of marbofloxacin were evaluated against 20 isolates of A. pleuropneumoniae . The mean peak plasma concentrations ( C m a x ) after i.v., i.m., and p.o administration were 2.60 ± 0.10 , 2.59 ± 0.12 , and 2.34 ± 0.12 µ g/mL at 0.25 ± 0.00 , 0.44 ± 0.10 , and 1.58 ± 0.40 h, respectively. The area under the plasma concentration-time curves (AUC 0–24 ) and elimination half-lives were 24.80 ± 0.90 , 25.80 ± 1.40 , and 23.40 ± 5.00 h· μ g/mL and 8.60 ± 0.30 , 12.80 ± 1.10 , and 8.60 ± 0.00 h, for i.v., i.m., and p.o. administration, correspondingly. The AUC 0–24 /MICs of marbofloxacin after i.v., i.m., and p.o. administration were 253.86 ± 179.91 , 264.1 ± 187.16 , and 239.53 ± 169.75 h, respectively. The C m a x /MIC values were 26.58 ± 18.84 , 26.48 ± 18.77 , and 23.94 ± 16.97 , and T 〉 MICs were 42.80 ± 1.01 , 36.40 ± 1.24 , and 38.60 ± 1.18 h, after i.v., i.m., and p.o. administration, respectively. Thus, marbofloxacin dosage of 2.50 mg/kg of body weight by i.v., i.m., and p.o. administration with 24 h dosing interval will provide effective treatment for the infection of pig by A. pleuropneumonia .
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
DOI:
10.1155/2017/2469826
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2017
detail.hit.zdb_id:
2698540-8
Permalink