In:
Intervirology, S. Karger AG, Vol. 55, No. 3 ( 2012), p. 231-241
Abstract:
〈 i 〉 Objective: 〈 /i 〉 To evaluate predictive factors of treatment efficacy to interferon (IFN)/ribavirin in patients infected with HCV genotype 1b (HCV-1b). 〈 i 〉 Methods: 〈 /i 〉 This study investigated pretreatment predictors, including viral- (aa substitutions in core aa 70/91 and NS5A-ISDR/IRRDR) and host-related factors (genetic variation near 〈 i 〉 IL28B 〈 /i 〉 gene), to 48-week IFN/ribavirin in 490 Japanese adults infected with HCV-1b. 〈 i 〉 Results: 〈 /i 〉 The proportion of patients who showed end-of-treatment response (ETR), sustained virological response (SVR), and SVR after ETR was 76, 54, and 76%, respectively. There was a significant positive correlation between the number of aa substitutions in ISDR and those in IRRDR. Concerning the substitution of core aa 91, the number of aa substitutions in ISDR/IRRDR of patients with Leu91 was significantly higher than that of patients with Met91. Furthermore, levels of viremia were influenced by aa substitutions in core aa 91 and ISDR/IRRDR. By multivariate analysis, rs8099917 genotype was an important predictor of ETR and SVR. With regard to viral factors, core aa 70/91 was an important predictor of ETR, and SVR after ETR. ISDR was an important predictor of SVR, and SVR after ETR. 〈 i 〉 Conclusion: 〈 /i 〉 aa substitution in core/NS5A region and genetic variation near 〈 i 〉 IL28B 〈 /i 〉 were important predictors of treatment efficacy to IFN/ribavirin.
Type of Medium:
Online Resource
ISSN:
0300-5526
,
1423-0100
Language:
English
Publisher:
S. Karger AG
Publication Date:
2012
detail.hit.zdb_id:
1482863-7
SSG:
12
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