In:
Journal of Intensive Care Medicine, SAGE Publications, Vol. 38, No. 1 ( 2023-01), p. 21-26
Abstract:
Purpose: Elevated ferritin levels are associated with poor outcomes in Covid-19 patients. Optimal timing of ferritin assessment and the merit of longitudinal values remains unclear. Methods: Patients admitted to Henry Ford Hospital with confirmed SARS-CoV-2 were studied. Regression models were used to determine the relation between ferritin and mortality, need for mechanical ventilation, ICU admission, and days on the ventilator. Results: 2265 patients were evaluated. Patients with an initial ferritin of 〉 490 ng/mL had an increased risk of death (OR 3.4, P 〈 .001), admission to the ICU (OR 2.78, P 〈 .001) and need for mechanical ventilation (OR 3.9, P 〈 .001). There was no difference between admission and Day 1 ICU ferritin levels (611.5 ng/mL vs. 649 ng/mL respectively; P = .07). The decline in ferritin over ICU days 1-4 was similar between survivors and non-survivors. A change in ferritin levels from admission to ICU Day 1 ( P = .330), or from ICU Day 1 to 2 ( P = .788), did not predict days on the ventilator. Conclusions: Initial Ferritin levels were highly predictive of ICU admission, the need for mechanical ventilation and in-hospital mortality. However, longitudinal measures of ferritin throughout the hospital stay did not provide additional predictive value.
Type of Medium:
Online Resource
ISSN:
0885-0666
,
1525-1489
DOI:
10.1177/08850666221113252
Language:
English
Publisher:
SAGE Publications
Publication Date:
2023
detail.hit.zdb_id:
2001472-7
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