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  • 1
    Online Resource
    Online Resource
    Larotrectinib induces autophagic cell death through AMPK/mTOR signalling in colon cancer
    Wiley ; 2022
    In:  Journal of Cellular and Molecular Medicine Vol. 26, No. 21 ( 2022-11), p. 5539-5550
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 26, No. 21 ( 2022-11), p. 5539-5550
    Abstract: Larotrectinib (Lar) is a highly selective and potent small‐molecule inhibitor used in patients with tropomyosin receptor kinase (TRK) fusion‐positive cancers, including colon cancer. However, the underlying molecular mechanisms specifically in patients with colon cancer have not yet been explored. Our data showed that Lar significantly suppressed proliferation and migration of colon cancer cells. In addition, Lar suppressed the epithelial–mesenchymal transition (EMT) process, as evidenced by elevation in E‐cadherin (E‐cad), and downregulation of vimentin and matrix metalloproteinase (MMP) 2/9 expression. Furthermore, Lar was found to activate autophagic flux, in which Lar increased the ratio between LC3II/LC3I and decreased the expression of p62 in colon cancer cells. More importantly, Lar also increased AMPK phosphorylation and suppressed mTOR phosphorylation in colon cancer cells. However, when we silenced AMPK in colon cancer cells, Lar‐induced accumulation of autolysomes as well as Lar‐induced suppression of the EMT process were significantly diminished. An in vivo assay also confirmed that tumour volume and weight decreased in Lar‐treated mice than in control mice. Taken together, this study suggests that Lar significantly suppresses colon cancer proliferation and migration by activating AMPK/mTOR‐mediated autophagic cell death.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v26.21
    DOI: 10.1111/jcmm.17530
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2076114-4
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  • 2
    Online Resource
    Online Resource
    Laser Sealing for Vacuum Plate Glass with PbO-TiO2-SiO2-RxOy Solder
    MDPI AG ; 2020
    In:  Sustainability Vol. 12, No. 8 ( 2020-04-13), p. 3118-
    Details
    In: Sustainability, MDPI AG, Vol. 12, No. 8 ( 2020-04-13), p. 3118-
    Abstract: Laser sealing for vacuum plate glass is a key step in developing the cost-effective smart vacuum-glass window for the drive towards net-zero energy buildings. In this paper, the pores, cracks, and interface with laser welding are analyzed in depth using PbO-TiO2-SiO2-RxOy system sealing solder to prepare vacuum flat glass. The microstructure of the sealing layer was analyzed by a BX41M-LED metallographic microscope, and the interfacial bonding characteristics were observed by thermal field emission scanning electron microscopy (SEM). The solder was analyzed by an energy spectrometer, and the influence of laser power, sealing temperature, and sealing speed on the gas holes and the crack sand interface separation of the sealing layer are reported. The results show that when the laser power reached 80 W at the welding speed of 2 mm/s, the bulk solder disappeared to most of the quantity and the sealing surface density was higher, due to which negligible pores and micro cracks were found. Thus, the sealing quality of the sealing layer is considered to be suitable when the temperature of 470 °C was maintained and the solder has 68.93% of Pb and 3.04% Si in the atom fraction to achieve the wet the glass substrate surface whilst improving the bonding quality.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su12083118
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2518383-7
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  • 3
    Online Resource
    Online Resource
    A Dual-Wideband Double-Layer Magnetoelectric Dipole Antenna with a Modified Horned Reflector for 2G/3G/LTE Applications
    Hindawi Limited ; 2013
    In:  International Journal of Antennas and Propagation Vol. 2013 ( 2013), p. 1-9
    Details
    In: International Journal of Antennas and Propagation, Hindawi Limited, Vol. 2013 ( 2013), p. 1-9
    Abstract: A novel dual-wideband double-layer magnetoelectric dipole unidirectional antenna with a modified horned reflector for 2G/3G/LTE applications is proposed. Firstly, a double-layer electric dipole structure is presented to provide a dualwideband, whose folded lower layer mainly serves the lower frequency band while the inclined upper layer works for the upper frequency band. In addition, to reduce the size of the antenna and improve impedance matching, a new feeding structure designed with inverted U-shaped and tapered line is introduced. Finally, a modified horn-shaped reflector, instead of a ground plane, is employed to achieve stable and high gains. The antenna prototype can achieve a bandwidth of 24.4% (790 MHz–1010 MHz) with a stable gain of 7.2 ± 0.6 dBi for the lower band, and a bandwidth of 67.3% (1.38 GHz–2.78 GHz) with a gain of 7.5 ± 0.8 dBi for the upper band covering all the frequency bands for 2G/3G/LTE systems. To the best of our knowledge, it is the first double-layer magnetoelectric dipole antenna proposed. Compared with the existing ME dipole antennas, the proposed antenna, which is completely made of copper, can be easily fabricated at low cost and thus is practicable for 2G/3G/LTE applications.
    Type of Medium: Online Resource
    ISSN: 1687-5869 , 1687-5877
    URL: Article
    DOI: 10.1155/2013/509589
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2397585-4
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  • 4
    Online Resource
    Online Resource
    Thermal Analysis of a New Neutron Shielding Vacuum Multiple Glass
    MDPI AG ; 2020
    In:  Sustainability Vol. 12, No. 8 ( 2020-04-12), p. 3083-
    Details
    In: Sustainability, MDPI AG, Vol. 12, No. 8 ( 2020-04-12), p. 3083-
    Abstract: The neutron shielding glass is widely used in nuclear/fusion plants. To improve its temperature resistance and heat insulation, a Gadolinium (Gd)-containing laminate vacuum multiple glass is proposed by using the vacuum insulation method. A 3D finite element model validated by theoretical calculation was developed to analyse the heat transfer path and numerical simulation of the multiple glass was carried out to obtain the temperature distribution and the maximum temperatures of the organic glass in relation to dynamic working temperatures, the sealing agent width, view size, and vacuum thermal conductivity. The results show that the vacuum layer between common glasses can make the work temperature of neutron shielding glass increase. The multiple glass has good heat-shielding performance and it is expected to work in a high-temperature environment. In addition, the vacuum layer between the common glasses and the sealing agent width decay with respect to the view size and vacuum thermal conductivity show an increase in the working temperature of the neutron shielding glass. It was concluded that the order of affecting the temperatures of the organic glass follows the pattern of: view size 〉 vacuum thermal conductivity 〉 sealing agent width.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su12083083
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2518383-7
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  • 5
    Online Resource
    Online Resource
    Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex
    American Association for the Advancement of Science (AAAS) ; 2021
    In:  Science Vol. 373, No. 6561 ( 2021-09-17), p. 1377-1381
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 373, No. 6561 ( 2021-09-17), p. 1377-1381
    Abstract: β barrel outer membrane proteins (β-OMPs) play vital roles in mitochondria, chloroplasts, and Gram-negative bacteria. Evolutionarily conserved complexes such as the mitochondrial sorting and assembly machinery (SAM) mediate the assembly of β-OMPs. We investigated the SAM-mediated assembly of the translocase of the outer membrane (TOM) core complex. Cryo–electron microscopy structures of SAM–fully folded Tom40 and the SAM-Tom40/Tom5/Tom6 complexes at ~3-angstrom resolution reveal that Sam37 stabilizes the mature Tom40 mainly through electrostatic interactions, thus facilitating subsequent TOM assembly. These results support the β barrel switching model and provide structural insights into the assembly and release of β barrel complexes.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.abh0704
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2021
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 6
    Online Resource
    Online Resource
    Facile fabrication of a highly (110)-oriented ZIF-7 film with rod-shaped seeds
    Royal Society of Chemistry (RSC) ; 2021
    In:  Chemical Communications Vol. 57, No. 17 ( 2021), p. 2128-2131
    Details
    In: Chemical Communications, Royal Society of Chemistry (RSC), Vol. 57, No. 17 ( 2021), p. 2128-2131
    Type of Medium: Online Resource
    ISSN: 1359-7345 , 1364-548X
    URL: Article
    DOI: 10.1039/D0CC07810G
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2021
    detail.hit.zdb_id: 1472881-3
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  • 7
    Online Resource
    Online Resource
    Recognition and Location of Pepper Picking Based on Improved YOLOv5s and Depth Camera
    American Society of Agricultural and Biological Engineers (ASABE) ; 2023
    In:  Applied Engineering in Agriculture Vol. 39, No. 2 ( 2023), p. 179-185
    Details
    In: Applied Engineering in Agriculture, American Society of Agricultural and Biological Engineers (ASABE), Vol. 39, No. 2 ( 2023), p. 179-185
    Abstract: Highlights An improved YOLOv5s deep learning model was used to identify peppers in complex background. The deep-level features on 3D (O-XYZ) coordinate of peppers were extracted using RealSense depth camera. An image database set of pepper in different scenes was established. A pepper recognition and location system were constructed based on improved YOLOv5s network. The proposed method achieved a mean average precision of 95.6% and minimum depth error of 0.001 m. Abstract. In order to investigate the impact of different scenes on the recognition performance and obtain the location information of picking targets, the recognition and location system based on improved YOLOv5s network and RealSense depth camera was constructed in this study. An image database in different scenes was established including light intensity, occlusion and overlap degree of pepper. An improved YOLOv5s deep learning model with bidirectional feature pyramid network (BiFPN) was used for the deep feature extraction and high-precision detection of pepper, and the effects of different scenes on recognition accuracy of the model were studied. The results showed that mean average precision (mAP) of YOLOv5s model reached 0.956, which was respectively 6.1%, 9.3%, 44.4%, and 8.2% higher than that of YOLOv4, YOLOv3, YOLOv2, and Faster R-CNN model. The model had good robustness under daytime and evening scenes with the mAP value higher than 0.9. The detection accuracy of the model in the leaf occlusion scenes was better than that of fruit overlap. The detection error was 0.001m which could not affect the picking positioning precision when the Z value of three-dimensional coordinates (O-XYZ) of pepper was 0.2 m. The improved algorithm can accurately recognize and extract three-dimensional coordinates of pepper, which reduces the calculations by eliminating lots of duplicate and redundant prediction boxes and provides a reference for trajectory planning of pepper picking operation. Keywords: Different scenes, Pepper recognition and location, Picking operation, YOLOv5s.
    Type of Medium: Online Resource
    ISSN: 1943-7838
    URL: Article
    DOI: 10.13031/aea.15347
    Language: English
    Publisher: American Society of Agricultural and Biological Engineers (ASABE)
    Publication Date: 2023
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  • 8
    Online Resource
    Online Resource
    A printed dual-wideband magneto-electric dipole antenna for WWAN/LTE applications
    Elsevier BV ; 2014
    In:  AEU - International Journal of Electronics and Communications Vol. 68, No. 10 ( 2014-10), p. 926-932
    Details
    In: AEU - International Journal of Electronics and Communications, Elsevier BV, Vol. 68, No. 10 ( 2014-10), p. 926-932
    Type of Medium: Online Resource
    ISSN: 1434-8411
    URL: Article
    DOI: 10.1016/j.aeue.2014.04.016
    RVK:
    ZG 1100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 120009-4
    detail.hit.zdb_id: 2046900-7
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  • 9
    Online Resource
    Online Resource
    Microstructure characteristics of vacuum glazing brazing joints using laser sealing technique
    Elsevier BV ; 2018
    In:  Optics & Laser Technology Vol. 101 ( 2018-05), p. 189-194
    Details
    In: Optics & Laser Technology, Elsevier BV, Vol. 101 ( 2018-05), p. 189-194
    Type of Medium: Online Resource
    ISSN: 0030-3992
    URL: Article
    DOI: 10.1016/j.optlastec.2017.11.016
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2000654-8
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  • 10
    Online Resource
    Online Resource
    Delineation of pentatricopeptide repeat codes for target RNA prediction
    Oxford University Press (OUP) ; 2019
    In:  Nucleic Acids Research Vol. 47, No. 7 ( 2019-04-23), p. 3728-3738
    Details
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 47, No. 7 ( 2019-04-23), p. 3728-3738
    Type of Medium: Online Resource
    ISSN: 0305-1048 , 1362-4962
    URL: Article
    DOI: 10.1093/nar/gkz075
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 1472175-2
    SSG: 12
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