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  • 1
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    Role of keratinocytes and immune cells in the anti-inflammatory effects of Tripterygium wilfordii Hook. f. in a murine model of psoriasis
    Elsevier BV ; 2020
    In:  Phytomedicine Vol. 77 ( 2020-10), p. 153299-
    Details
    In: Phytomedicine, Elsevier BV, Vol. 77 ( 2020-10), p. 153299-
    Type of Medium: Online Resource
    ISSN: 0944-7113
    URL: Article
    DOI: 10.1016/j.phymed.2020.153299
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2040195-4
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  • 2
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    Efficacy of fish oil and its components in the management of psoriasis: a systematic review of 18 randomized controlled trials
    Oxford University Press (OUP) ; 2020
    In:  Nutrition Reviews Vol. 78, No. 10 ( 2020-10-01), p. 827-840
    Details
    In: Nutrition Reviews, Oxford University Press (OUP), Vol. 78, No. 10 ( 2020-10-01), p. 827-840
    Abstract: Fish oil and omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have anti-inflammatory properties, but their effect on psoriasis and its comorbidities remains inconclusive. Objective The aim of this quantitative systematic review was to evaluate the efficacy and safety of fish oil and its components in the treatment of psoriasis and its comorbidities. Data Sources PubMed, Embase, Cochrane Central Register of Controlled Trials, China Network Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang databases were searched from inception to March 30, 2019. Study Selection Randomized controlled trials were eligible for inclusion if they measured the effect of fish oil and its components in the treatment of patients with psoriasis. Data Extraction Eighteen randomized controlled trials involving 927 study participants were included. Results Monotherapy with fish oil or ω-3 PUFAs had no effect on the Psoriasis Area and Severity Index (PASI) score (P = 0.47), lesion area (P = 0.34), or pruritus (P = 0.62). Fish oil or ω-3 PUFAs combined with conventional treatments, however, resulted in a decreased PASI score (mean difference [MD], −3.92; 95%CI, −6.15 to −1.69; P = 0.0006) and lesion area (MD, −30.00; 95%CI, −33.82 to −26.18; P  & lt; 0.0001). Safety evaluation suggested no between-group differences. Fish oil and its components reduced certain risk factors for obesity, cardiovascular disease, and metabolic disease in patients with psoriasis and also regulated several inflammatory mediators. Conclusions Overall, when combined with conventional treatments, fish oil and its components may have beneficial effects on psoriasis and its comorbidities, including obesity, cardiovascular disease, and metabolic disease. Systematic Review Registration PROSPERO registration number CRD42019128631.
    Type of Medium: Online Resource
    ISSN: 0029-6643 , 1753-4887
    URL: Article
    DOI: 10.1093/nutrit/nuz098
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2066844-2
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  • 3
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    Table_3.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Medicine Vol. 9 ( 2022-8-11)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 9 ( 2022-8-11)
    Abstract: Abnormal lipid distribution is observed in patients with psoriasis, which increases their risk for atherosclerosis. Lipid-lowering drugs have a certain curative effect in the treatment of psoriasis, but there is no relevant evidence-based medical evaluation. Objective The purpose of this systematic evaluation was to assess the efficacy, safety, and potential mechanisms of action of lipid-lowering drugs for the treatment of psoriasis. Methods The PubMed, Embase, Cochrane Central Register of Controlled Trials, Clinical Trial, Chinese National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database, and Wanfang Database were searched for relevant articles from inception to 31 December 2021. The RevMan 5.3 and Cochrane risk-of-bias tool were used for data analysis and risk assessment, respectively. The psoriasis area and severity index (PASI) score is the primary outcome indicator in clinical studies. Based on preclinical studies, we elucidated and mapped the action mechanisms of lipid-lowering drugs in the treatment of psoriasis. Results The study included eight randomized controlled studies, four single-arm studies, and four in vitro studies. The results showed that lipid-lowering drugs, particularly statins, administered both orally and topically, can significantly improve psoriatic skin lesions and reduce the PASI scores [standardized mean difference, (SMD): −0.94; 95% CI: [−1.58, −0.31]; p = 0.004]. Oral statins performed best at week eight (SMD: −0.92; 95% CI: [−1.39, −0.44] ; p = 0.0001). The mechanism of lipid-lowering drugs in the treatment of psoriasis may be related to the inhibition of keratinocyte proliferation, inhibition of CCL20–CCR6 interaction, and reduction in the levels of inflammatory factors. Limitations There are few studies on lipid-lowering drugs and psoriasis, and their small sample sizes may render the evidence unconvincing. Conclusion The present findings suggest that lipid-lowering drugs are relieving symptoms in psoriasis. Lipid-lowering drugs, particularly statins, can be used to treat psoriasis with good efficacy and few side effects.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2022.900916
    DOI: 10.3389/fmed.2022.900916.s001
    DOI: 10.3389/fmed.2022.900916.s002
    DOI: 10.3389/fmed.2022.900916.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2775999-4
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  • 4
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    Seismic Ground Response Estimation Based on Convolutional Neural Networks (CNN)
    MDPI AG ; 2021
    In:  Applied Sciences Vol. 11, No. 22 ( 2021-11-15), p. 10760-
    Details
    In: Applied Sciences, MDPI AG, Vol. 11, No. 22 ( 2021-11-15), p. 10760-
    Abstract: One of the purposes of earthquake engineering is to mitigate the damages in buildings and infrastructures and, therefore, reduce the impact of earthquakes on society. Seismic ground response analysis refers to the process of evaluating the ground surface motions based on the bedrock motion. On the other hand, deep learning techniques have been developing fast, and they are establishing their application in the civil engineering field. This study proposes two convolutional neural network (CNN) models to estimate the seismic response of the surface based on the seismic motion measured at 100 m level beneath the surface, and selected the one which outperforms the other as the main model. The performances of the main model are compared with those of a physical software SHAKE2000. Twelve sites that include 100 earthquake datasets, whose moment magnitude is higher than 6 and PGA is higher than 0.1 g, were selected. In addition, the corresponding earthquake datasets are used for the CNN model. Whereas the conventional software overestimated the values of the amplitudes for most of the sites, the proposed CNN model predicts fairly well both the values of the amplitudes and the natural periods where responses amplify the most with few exceptions. The proposed model especially outperforms the conventional software when the natural periods range from 0.01 to 0.3 s. For specific sites, the average mean squared errors of the proposed model are even dozens of times lower than those of the conventional physical software.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app112210760
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2704225-X
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  • 5
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    Table3.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-9-27)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-9-27)
    Abstract: Background: The use of Chinese herbal medicine (CHM) for the treatment of atopic dermatitis (AD) has gained attention. This quantitative study systematically evaluated the efficacy and safety of CHM for the treatment of AD in eight high-level clinical trials, resulting in a high level of clinical evidence. Methods: Several databases were searched, including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), the Chongqing VIP Chinese Science (VIP), and Wanfang Database. High-quality randomized controlled trials (RCTs) comparing CHM with placebo were included. The 95% confidence interval (CI) of the risk ratio (RR) was calculated using software (RevMan 5.3) and a meta-analysis was performed. Evidence level evaluation using GRADE Profiler 3.6. Results: In total, 662 patients (322 in the experimental group and 340 in the control group) were included. The response rate of the Eczema Area and Severity Index (EASI) −90 was higher in the CHM group than in the placebo group (RR, 3.72; 95% CI, 1.76 to7.83; p = 0.01). Furthermore, the scoring of atopic dermatitis (SCORAD) (RR, −10.20), body surface area (BSA) (RR, −2.01), surface damage score (RR, −2.25), visual analog scale (VAS) (RR, −1.90), and sleep score (RR, −2.16), improvement of investigator’s global assessment (IGA) (RR, 2.94) improved in the CHM group. The results showed no statistical difference between CHM and placebo (MD, −0.47; 95% CI, −1.30, 0.37; p = 0.27) in improving the Dermatology Life Quality Index (DLQI) or children’s DLQI (CDLQI). There was also no significant difference in the IgE level between the two groups (MD, −62.76; 95% CI, −809.58, 684.05; p = 0.87). However, the adverse events (AEs) rate was slightly higher in patients treated with CHM than in those treated with placebo (RR, 1.42; 95% CI, 1.06–1.90; p = 0.02). Conclusion: CHM improved the size and severity of the skin lesions and sleep quality in patients with AD. Comparing the adverse effects between the two groups, CHM is safe. However, CHM does not improve the quality of life or the patient’s IgE levels.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2022.927304
    DOI: 10.3389/fphar.2022.927304.s001
    DOI: 10.3389/fphar.2022.927304.s002
    DOI: 10.3389/fphar.2022.927304.s003
    DOI: 10.3389/fphar.2022.927304.s004
    DOI: 10.3389/fphar.2022.927304.s005
    DOI: 10.3389/fphar.2022.927304.s006
    DOI: 10.3389/fphar.2022.927304.s007
    DOI: 10.3389/fphar.2022.927304.s008
    DOI: 10.3389/fphar.2022.927304.s009
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
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  • 6
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    Exploration of and insights into advanced topical nanocarrier systems for the treatment of psoriasis
    Frontiers Media SA ; 2022
    In:  Frontiers in Medicine Vol. 9 ( 2022-12-15)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 9 ( 2022-12-15)
    Abstract: Psoriasis is a chronic inflammatory skin disease with an underlying autoimmune pathogenesis that has brought great distress to patients. Current treatment options include topical therapy, systemic therapy, and phototherapy. By disrupting the stratum corneum, nanocarriers have unique advantages in allowing drug carriers to be tailored to achieve targeted drug delivery, improve efficacy, and minimize adverse effects. Furthermore, despite their limited success in market translatability, nanocarriers have been extensively studied for psoriasis, owing to their excellent preclinical results. As topical formulations are the first line of treatment, utilize the safest route, and facilitate a targeted approach, this study, we specifically describes the management of psoriasis using topical agents in conjunction with novel drug delivery systems. The characteristics, advantages, weaknesses, and mechanisms of individual nanocarriers, when applied as topical anti-psoriatic agents, were reviewed to distinguish each nanocarrier.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    DOI: 10.3389/fmed.2022.1017126
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2775999-4
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  • 7
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    Establishment of Mouse Models of Psoriasis with Blood Stasis Syndrome Complicated with Glucose and Lipid Metabolism Disorders
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-11-12), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-11-12), p. 1-10
    Abstract: Background . Psoriasis has been reported as a high-risk factor for quality of life and survival rate in patients with metabolic disorder. However, there is no animal model for studying this disease. This study aimed to establish and evaluate mouse models of psoriasis with blood stasis syndrome (which is a key to psoriasis pathogenesis, according to Chinese Medicine) complicated with metabolic disorders. Method . Forty-five C57BL/6 mice were randomly divided into the blank control (Control), psoriasis (Imiquimod (IMQ)), psoriasis with metabolic disorders (IMQ + streptozotocin (STZ)), psoriasis with blood stasis syndrome (BSS) (IMQ + BSS), and psoriasis with blood stasis syndrome complicated with metabolic disorders (IMQ + STZ + BSS) groups ( n  = 9 mice/group). Psoriasis lesions were induced using IMQ cream (on both the ears and back, except in the Control group). Mice of the IMQ + BSS group were fed a half-fat, high-sugar diet and stimulated with ice-water swimming every day. Mice of the IMQ + STZ group were fed a half-fat, high-sugar diet and injected with STZ. Mice of the IMQ + STZ + BSS group were subjected to the same treatments as the IMQ + STZ and IMQ + BSS groups. After induction, the mice in each group were observed for vital signs, ear thickness, body weight, and psoriasis area and severity index (PASI) score. The mice were fasted for 12 h before determination of related laboratory serum indexes. Dorsal skin lesions, aortic arch pathology sections, and signal transducer and activator of transcription 3 (STAT3) were examined by H & E staining and immunohistochemistry. Results . Laboratory indexes in the four model groups were significantly different from those in the Control group ( p 〈 0.01 ); indicators of the IMQ + STZ, IMQ + BSS, and IMQ + STZ + BSS groups showed varying degrees of difference from those of the IMQ group. Conclusions . The established mouse models of psoriasis blood stasis syndrome complicated with glucose and lipid metabolism disorders met the clinical and Chinese Medicine characteristics, and thus they could be used as animal models in future studies of psoriasis complicated with glucose and lipid metabolism disorders.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/6419509
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 8
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    Seismic Ground Response Prediction Based on Multilayer Perceptron
    MDPI AG ; 2021
    In:  Applied Sciences Vol. 11, No. 5 ( 2021-02-26), p. 2088-
    Details
    In: Applied Sciences, MDPI AG, Vol. 11, No. 5 ( 2021-02-26), p. 2088-
    Abstract: Earthquake disasters can cause enormous social and economic damage, and therefore the sustainability of infrastructure requires the mitigation of earthquake consequences. In seismic design of infrastructures, it is essential to estimate the response of the site during earthquake. Geotechnical engineers have developed quantitative methods for analyzing the seismic ground response. This study proposes a multilayer perceptron (MLP) model to evaluate the seismic response of the surface based on the seismic motion at the bedrock (or 100 m level), and compares its performance with that of a conventional model. A total of 6 sites, with 100 earthquake events at each site, were selected from the Kiban Kyoshin Network (KiK-net) and used as datasets. The acceleration response spectra were calculated from the predicted and measured (baseline) acceleration histories and compared. The proposed MLP model predicted the magnitudes of response and the natural periods where the response amplifies closely with the measured ground motions (baseline). The MLP model outperformed the conventional model for seismic ground response analysis. However, the proposed model did not perform as well for earthquakes whose response spectra exceed 2 g due to a deficiency in large earthquake measurements in the training datasets.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app11052088
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
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  • 9
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    Seismic Ground Response Analysis Based on Multilayer Perceptron and Convolution Neural Networks
    Korean Society of Hazard Mitigation ; 2021
    In:  Journal of the Korean Society of Hazard Mitigation Vol. 21, No. 1 ( 2021-02-28), p. 231-238
    Details
    In: Journal of the Korean Society of Hazard Mitigation, Korean Society of Hazard Mitigation, Vol. 21, No. 1 ( 2021-02-28), p. 231-238
    Abstract: The importance of establishing a disaster prevention plan considering seismic performance is being highlighted to reduce damage to structures caused by earthquakes. Earthquake waves propagate from the bedrock to the ground surface through the soil. During the transmission process, they are amplified in a specific frequency range, and the degree of amplification depends mainly on the characteristics of the ground. Therefore, a seismic response analysis process is essential for enhancing the reliability of the seismic design. We propose a model for predicting seismic waves on the surface from seismic waves measured on the bedrock based on Multilayer Perceptron (MLP) and Convolutional Neural Networks (CNN) and validate the applicability of the proposed model with Spectral Acceleration (SA). Both the proposed models based on MLP and CNN successfully predicted the seismic response of the surface. The CNN-based model performed better than the MLP-based model, with a 10% smaller average error. We plan to implement the physical properties of the ground, such as shear wave velocity, to create a more versatile model in the future.
    Type of Medium: Online Resource
    ISSN: 1738-2424 , 2287-6723
    URL: Article
    DOI: 10.9798/KOSHAM.2021.21.1.231
    Language: English
    Publisher: Korean Society of Hazard Mitigation
    Publication Date: 2021
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  • 10
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    Efficacy and Safety of Fire Needle Therapy for Nodular Prurigo: A Quantitative Study
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-06-25), p. 1-12
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-06-25), p. 1-12
    Abstract: In this quantitative study, we evaluated the effectiveness and safety of fire needle therapy for nodular prurigo. We systematically searched several databases, including EMBASE, PubMed, the Cochrane Library, the Web of Science, the China Network Knowledge Infrastructure, the Wanfang Data Knowledge Service Platform, and the China Science and Technology Journal Database, and retrieved randomized controlled trials comparing conventional therapies (control group) with fire needle therapy alone or in combination with conventional therapies. Revman 5.2 software was used to calculate risk ratios (RR) with 95% confidence intervals (CI). In total, 14 trials with 1176 participants were included. Our quantitative study showed that the effectiveness rate of fire needle therapy combined with conventional therapies was significantly higher than that of conventional therapies alone (fire needle + traditional Chinese medicine [TCM] vs. TCM: RR, 1.11; 95% CI, 1.04 to 1.18; fire needle + oral thalidomide + topical glucocorticoid [TGC] vs. thalidomide + TGC: RR, 1.41; 95% CI, 1.17 to 1.70; fire needle + TGC vs. TGC only: RR, 1.18; 95% CI, 1.07 to 1.31). Similar results were obtained for the Symptom Score Reducing Index (fire needle + TCM vs. TCM: mean difference [MD] , −3.39; 95% CI: −5.39 to −1.39), visual analog scale scores for itching severity (fire needle vs. halometasone cream: MD, −0.93; 95% CI, −1.29 to −0.58; fire needle + TCM vs. TCM: MD, −1.18; 95% CI, −1.78 to −0.58), and Dermatology Life Quality Index (fire needle vs. halometasone cream: MD, −3.03; 95% CI, −3.43 to −2.63; fire needle + TCM vs. TCM: MD, −2.53; 95% CI, −3.12 to −1.94). Adverse event and recurrence rates were comparable between groups. Thus, fire needle therapy alone or combined with conventional treatments may be effective for nodular prurigo, without any additional side effects.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/8797056
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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