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  • 1
    In: Radiation Research, Radiation Research Society, Vol. 182, No. 6 ( 2014-12), p. 607-617
    Type of Medium: Online Resource
    ISSN: 0033-7587 , 1938-5404
    RVK:
    Language: English
    Publisher: Radiation Research Society
    Publication Date: 2014
    detail.hit.zdb_id: 2135113-2
    detail.hit.zdb_id: 80322-4
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2008
    In:  European Journal of Radiology Vol. 68, No. 3 ( 2008-12), p. S137-S141
    In: European Journal of Radiology, Elsevier BV, Vol. 68, No. 3 ( 2008-12), p. S137-S141
    Type of Medium: Online Resource
    ISSN: 0720-048X
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2008
    detail.hit.zdb_id: 2005350-2
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  • 3
    In: Medical Physics, Wiley, Vol. 42, No. 9 ( 2015-09), p. 5517-5529
    Abstract: The purpose of this work was to adapt a lightweight, permanent magnet electron energy spectrometer for the measurement of energy spectra of therapeutic electron beams. Methods: An irradiation geometry and measurement technique were developed for an approximately 0.54‐T, permanent dipole magnet spectrometer to produce suitable latent images on computed radiography (CR) phosphor strips. Dual‐pinhole electron collimators created a 0.318‐cm diameter, approximately parallel beam incident on the spectrometer and an appropriate dose rate at the image plane (CR strip location). X‐ray background in the latent image, reduced by a 7.62‐cm thick lead block between the pinhole collimators, was removed using a fitting technique. Theoretical energy‐dependent detector response functions (DRFs) were used in an iterative technique to transform CR strip net mean dose profiles into energy spectra on central axis at the entrance to the spectrometer. These spectra were transformed to spectra at 95‐cm source to collimator distance (SCD) by correcting for the energy dependence of electron scatter. The spectrometer was calibrated by comparing peak mean positions in the net mean dose profiles, initially to peak mean energies determined from the practical range of central‐axis percent depth‐dose (%DD) curves, and then to peak mean energies that accounted for how the collimation modified the energy spectra (recalibration). The utility of the spectrometer was demonstrated by measuring the energy spectra for the seven electron beams (7–20 MeV) of an Elekta Infinity radiotherapy accelerator. Results: Plots of DRF illustrated their dependence on energy and position in the imaging plane. Approximately 15 iterations solved for the energy spectra at the spectrometer entrance from the measured net mean dose profiles. Transforming those spectra into ones at 95‐cm SCD increased the low energy tail of the spectra, while correspondingly decreasing the peaks and shifting them to slightly lower energies. Energy calibration plots of peak mean energy versus peak mean position of the net mean dose profiles for each of the seven electron beams followed the shape predicted by the Lorentz force law for a uniform z ‐component of the magnetic field, validating its being modeled as uniform (0.542 ± 0.027 T). Measured Elekta energy spectra and their peak mean energies correlated with the 0.5‐cm (7–13 MeV) and the 1.0‐cm (13–20 MeV) R 90 spacings of the %DD curves. The full‐width‐half‐maximum of the energy spectra decreased with decreasing peak mean energy with the exception of the 9‐MeV beam, which was anomalously wide. Similarly, R 80–20 decreased linearly with peak mean energy with the exception of the 9 MeV beam. Both were attributed to suboptimal tuning of the high power phase shifter for the recycled radiofrequency power reentering the traveling wave accelerator. Conclusions: The apparatus and analysis techniques of the authors demonstrated that an inexpensive, lightweight, permanent magnet electron energy spectrometer can be used for measuring the electron energy distributions of therapeutic electron beams (6–20 MeV). The primary goal of future work is to develop a real‐time spectrometer by incorporating a real‐time imager, which has potential applications such as beam matching, ongoing beam tune maintenance, and measuring spectra for input into Monte Carlo beam calculations.
    Type of Medium: Online Resource
    ISSN: 0094-2405 , 2473-4209
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1466421-5
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  • 4
    In: Medical Physics, Wiley, Vol. 39, No. 12 ( 2012-12), p. 7462-7469
    Abstract: Ion chamber dosimetry is being used to calibrate dose for cell irradiations designed to investigate photoactivated Auger electron therapy at the Louisiana State University Center for Advanced Microstructures and Devices (CAMD) synchrotron facility. This study performed a dosimetry intercomparison for synchrotron‐produced monochromatic x‐ray beams at 25 and 35 keV. Ion chamber depth‐dose measurements in a polymethylmethacrylate (PMMA) phantom were compared with the product of MCNP5 Monte Carlo calculations of dose per fluence and measured incident fluence. Methods: Monochromatic beams of 25 and 35 keV were generated on the tomography beamline at CAMD. A cylindrical, air‐equivalent ion chamber was used to measure the ionization created in a 10 × 10 × 10‐cm 3 PMMA phantom for depths from 0.6 to 7.7 cm. The American Association of Physicists in Medicine TG‐61 protocol was applied to convert measured ionization into dose. Photon fluence was determined using a NaI detector to make scattering measurements of the beam from a thin polyethylene target at angles 30°–60°. Differential Compton and Rayleigh scattering cross sections obtained from xraylib , an ANSI C library for x‐ray‐matter interactions, were applied to derive the incident fluence. MCNP5 simulations of the irradiation geometry provided the dose deposition per photon fluence as a function of depth in the phantom. Results: At 25 keV the fluence‐normalized MCNP5 dose overestimated the ion‐chamber measured dose by an average of 7.2 ± 3.0%–2.1 ± 3.0% for PMMA depths from 0.6 to 7.7 cm, respectively. At 35 keV the fluence‐normalized MCNP5 dose underestimated the ion‐chamber measured dose by an average of 1.0 ± 3.4%–2.5 ± 3.4%, respectively. Conclusions: These results showed that TG‐61 ion chamber dosimetry, used to calibrate dose output for cell irradiations, agreed with fluence‐normalized MCNP5 calculations to within approximately 7% and 3% at 25 and 35 keV, respectively.
    Type of Medium: Online Resource
    ISSN: 0094-2405 , 2473-4209
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 1466421-5
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  • 5
    Online Resource
    Online Resource
    IOP Publishing ; 2007
    In:  Physics in Medicine and Biology Vol. 52, No. 9 ( 2007-05-07), p. 2459-2481
    In: Physics in Medicine and Biology, IOP Publishing, Vol. 52, No. 9 ( 2007-05-07), p. 2459-2481
    Type of Medium: Online Resource
    ISSN: 0031-9155 , 1361-6560
    RVK:
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2007
    detail.hit.zdb_id: 1473501-5
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Elsevier BV ; 2010
    In:  International Journal of Radiation Oncology*Biology*Physics Vol. 77, No. 3 ( 2010-07), p. 836-842
    In: International Journal of Radiation Oncology*Biology*Physics, Elsevier BV, Vol. 77, No. 3 ( 2010-07), p. 836-842
    Type of Medium: Online Resource
    ISSN: 0360-3016
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2010
    detail.hit.zdb_id: 1500486-7
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  • 7
    In: Medical Physics, Wiley, Vol. 39, No. 12 ( 2012-12), p. 7412-7417
    Abstract: This work investigates the dose‐response curves of GAFCHROMIC® EBT, EBT2, and EBT3 radiochromic films using synchrotron‐produced monochromatic x‐ray beams. EBT2 film is being utilized for dose verification in photoactivated Auger electron therapy at the Louisiana State University Center for Advanced Microstructures and Devices (CAMD) synchrotron facility. Methods: Monochromatic beams of 25, 30, and 35 keV were generated on the tomography beamline at CAMD. Ion chamber depth‐dose measurements were used to determine the dose delivered to films irradiated at depths from 0.7 to 8.5 cm in a 10 × 10 × 10‐cm 3 polymethylmethacrylate phantom. AAPM TG‐61 protocol was applied to convert measured ionization into dose. Films were digitized using an Epson 1680 Professional flatbed scanner and analyzed using the net optical density (NOD) derived from the red channel. A dose‐response curve was obtained at 35 keV for EBT film, and at 25, 30, and 35 keV for EBT2 and EBT3 films. Calibrations of films for 4 MV x‐rays were obtained for comparison using a radiotherapy accelerator at Mary Bird Perkins Cancer Center. Results: The sensitivity (NOD per unit dose) of EBT film at 35 keV relative to that for 4‐MV x‐rays was 0.73 and 0.76 for doses 50 and 100 cGy, respectively. The sensitivity of EBT2 film at 25, 30, and 35 keV relative to that for 4‐MV x‐rays varied from 1.09–1.07, 1.23–1.17, and 1.27–1.19 for doses 50–200 cGy, respectively. For EBT3 film the relative sensitivity was within 3% of unity for all three monochromatic x‐ray beams. Conclusions: EBT and EBT2 film sensitivity showed strong energy dependence over an energy range of 25 keV–4 MV, although this dependence becomes weaker for larger doses. EBT3 film shows weak energy dependence, indicating that it would be a better dosimeter for kV x‐ray beams where beam hardening effects can result in large changes in the effective energy.
    Type of Medium: Online Resource
    ISSN: 0094-2405 , 2473-4209
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 1466421-5
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  • 8
    In: Medical Physics, Wiley, Vol. 38, No. 12 ( 2011-12), p. 6610-6622
    Abstract: The purpose of this work was to investigate the potential of discrete Gaussian edge feathering of the higher energy electron fields for improving abutment dosimetry in the planning volume when using an electron multileaf collimator (eMLC) to deliver segmented‐field electron conformal therapy (ECT). Methods: A discrete (five‐step) Gaussian edge spread function was used to match dose penumbras of differing beam energies (6–20 MeV) at a specified depth in a water phantom. Software was developed to define the leaf eMLC positions of an eMLC that most closely fit each electron field shape. The effect of 1D edge feathering of the higher energy field on dose homogeneity was computed and measured for segmented‐field ECT treatment plans for three 2D PTVs in a water phantom, i.e., depth from the water surface to the distal PTV surface varied as a function of the x ‐axis (parallel to leaf motion) and remained constant along the y ‐axis (perpendicular to leaf motion). Additionally, the effect of 2D edge feathering was computed and measured for one radially symmetric, 3D PTV in a water phantom, i.e., depth from the water surface to the distal PTV surface varied as a function of both axes. For the 3D PTV, the feathering scheme was evaluated for 0.1–1.0‐cm leaf widths. Dose calculations were performed using the pencil beam dose algorithm in the Pinnacle 3 treatment planning system. Dose verification measurements were made using a prototype eMLC (1‐cm leaf width). Results: 1D discrete Gaussian edge feathering reduced the standard deviation of dose in the 2D PTVs by 34, 34, and 39%. In the 3D PTV, the broad leaf width (1 cm) of the eMLC hindered the 2D application of the feathering solution to the 3D PTV, and the standard deviation of dose increased by 10%. However, 2D discrete Gaussian edge feathering with simulated eMLC leaf widths of 0.1–0.5 cm reduced the standard deviation of dose in the 3D PTV by 33–28%, respectively. Conclusions: A five‐step discrete Gaussian edge spread function applied in 2D improves the abutment dosimetry but requires an eMLC leaf resolution better than 1 cm.
    Type of Medium: Online Resource
    ISSN: 0094-2405 , 2473-4209
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1466421-5
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  • 9
    In: Practical Radiation Oncology, Elsevier BV, Vol. 4, No. 1 ( 2014-01), p. e67-e73
    Type of Medium: Online Resource
    ISSN: 1879-8500
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
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  • 10
    Online Resource
    Online Resource
    Wiley ; 2002
    In:  Medical Physics Vol. 29, No. 5 ( 2002-05), p. 771-786
    In: Medical Physics, Wiley, Vol. 29, No. 5 ( 2002-05), p. 771-786
    Abstract: The purpose of this study was to investigate the feasibility of using Monte Carlo methods to assist in the commissioning of electron beams for a medical linear accelerator. The EGS4/BEAM code system was used to model an installed linear accelerator at this institution. Following an initial tuning of the input parameters, dosimetry data normally measured during the machine commissioning was calculated using the Monte Carlo code. All commissioning data was calculated for 6‐ and 12‐MeV electron beams, and a subset of the commissioning data was calculated for the 20‐MeV electron beams. On central axis, calculated percentage depth dose, cross‐beam profiles, cone‐insert ratios, and air‐gap factors were generally within 2% of or 1 mm of the measured commissioning data; however, calculated open‐cone ratios were not within 2%, in most cases. Calculated off‐axis dose profiles for small fields were generally within the 2% (1‐mm) criteria; however, calculated dose profiles for larger (open cone) fields frequently failed the 2% (1‐mm) criteria. The remaining discrepancies between Monte Carlo calculations and measurement could be due to flaws in the Monte Carlo code, inaccuracies in the simulation geometry, the approximation of the initial source configuration, or a combination of the above. Although agreement between Monte Carlo calculated and measured doses was impressive and similar to previously published comparisons, our results did not prove our hypothesis that Monte Carlo calculations can generate electron commissioning data that is accurate within 2% of or 0.1 cm over the entire range of clinical treatment parameters. Although we believe that this hypothesis can be proved, it remains a challenge for the medical physics community. We intend to pursue this further by developing systematic methods for isolating causes of these differences.
    Type of Medium: Online Resource
    ISSN: 0094-2405 , 2473-4209
    Language: English
    Publisher: Wiley
    Publication Date: 2002
    detail.hit.zdb_id: 1466421-5
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