In:
Neurodegenerative Diseases, S. Karger AG, Vol. 7, No. 4 ( 2010), p. 232-238
Abstract:
〈 i 〉 Background: 〈 /i 〉 The metalloproteinases ADAM10 and ADAM17 are involved in various diseases: neurodegeneration, cancer and inflammation. 〈 i 〉 Objective: 〈 /i 〉 The inhibition of these proteases is a promising target in the treatment of inflammation and cancer. 〈 i 〉 Methods and Results: 〈 /i 〉 In this study, we present an improved synthesis of the ADAM10 reference inhibitor GI254023X with a higher overall yield, enhanced detection ability and increased acid stability, providing easier handling. 〈 i 〉 Conclusion: 〈 /i 〉 This upscaled synthesis, free of diastereomeric intermediates, ensures single-batch identity, thus warranting its reproducibility in further biological investigations.
Type of Medium:
Online Resource
ISSN:
1660-2854
,
1660-2862
Language:
English
Publisher:
S. Karger AG
Publication Date:
2010
detail.hit.zdb_id:
2126858-7
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