In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 16, No. 743 ( 2024-04-17)
Abstract:
It is well-established that older adults are at increased risk of severe and fatal COVID-19, but the mechanisms underlying this susceptibility are not entirely clear. To better understand features associated with age and COVID-19 severity, Phan et al . comprehensively studied the immune response to SARS-CoV-2 in a large longitudinal clinical cohort. By integrating mass cytometry, serum proteomics, antibody assays, and transcriptional analysis, the authors found that age was associated with increased viral load, delayed viral clearance, and alterations to immune cell frequencies. Markers of disease severity, such as interleukin-6, were the most extreme in the oldest patients. Together, these data provide insight into why age is a major risk factor for severe COVID-19. —Courtney Malo
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.adj5154
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2024
detail.hit.zdb_id:
2518839-2
detail.hit.zdb_id:
2518854-9
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