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  • 1
    Online Resource
    Online Resource
    POTENTIAL PATHOPHYSIOLOGICAL ROLE OF ALDOSTERONE IN MAJOR DEPRESSIVE DISORDER
    Elsevier BV ; 2018
    In:  Pathophysiology Vol. 25, No. 3 ( 2018-09), p. 187-
    Details
    In: Pathophysiology, Elsevier BV, Vol. 25, No. 3 ( 2018-09), p. 187-
    Type of Medium: Online Resource
    ISSN: 0928-4680
    URL: Article
    DOI: 10.1016/j.pathophys.2018.07.064
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2031212-X
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  • 2
    Online Resource
    Online Resource
    Chronic treatment with the mineralocorticoid hormone aldosterone results in increased anxiety-like behavior
    Elsevier BV ; 2008
    In:  Hormones and Behavior Vol. 54, No. 1 ( 2008-6), p. 90-97
    Details
    In: Hormones and Behavior, Elsevier BV, Vol. 54, No. 1 ( 2008-6), p. 90-97
    Type of Medium: Online Resource
    ISSN: 0018-506X
    URL: Article
    DOI: 10.1016/j.yhbeh.2008.02.004
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2008
    detail.hit.zdb_id: 1467984-X
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Analysis of Motives and Factors Connected to Suicidal Behavior in Patients Hospitalized in a Psychiatric Department
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 10 ( 2022-05-22), p. 6283-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 10 ( 2022-05-22), p. 6283-
    Abstract: (1) Background: This study aimed to investigate the motives and factors connected to suicidal behavior in 121 hospitalized patients with intentional self-harm (diagnosis X 60-81 according to the ICD-10); (2) Methods: Suicidal behavior of the patient was assessed from data obtained by psychiatric examinations and by the Columbia Suicide Severity Rating Scale. Analysis of data to identify the patients’ reason and motives behind suicidal behavior in a group of patients with a suicide attempt (SA, n = 80) and patients with Non-Suicidal Self-Injurious Behavior (NSSIB, n = 41) was carried out; (3) Results: Results showed that patients with affective disorder have a 19-times higher rate of SA against other diagnoses. Patients with personality disorders have a 32-times higher rate of NSSIB than patients with other diagnoses. Living alone and the absence of social support increased the likelihood of SA. Qualitative data analysis of patients’ statements showed different themes in the justification of motives for suicidal behavior between SA and NSSIB cases. Significant differences were shown for non-communicated reasons, loneliness, social problems, extortion, and distress; (4) Conclusions: The evaluation of patients’ verbal statements by qualitative analysis during the psychiatric examination should be considered in clinical practice. It should be considered to include self-poisoning in the criteria of the Non-suicidal Self-Injury diagnostic categories.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph19106283
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 4
    Online Resource
    Online Resource
    Endocrine Factors in Stress and Psychiatric Disorders : Focus on Anxiety and Salivary Steroids
    Wiley ; 2008
    In:  Annals of the New York Academy of Sciences Vol. 1148, No. 1 ( 2008-12), p. 495-503
    Details
    In: Annals of the New York Academy of Sciences, Wiley, Vol. 1148, No. 1 ( 2008-12), p. 495-503
    Abstract: Glucocorticoids and other steroids produced in the adrenal cortex are altered in chronic stress situations associated with enhanced anxiety. A useful tool to evaluate changes in adrenal steroids during stress and anxiety under both laboratory and real‐life stress situations is determination of steroids in saliva. The main advantages of this technique are its noninvasiveness and its measurement of biologically active free hormone levels. Salivary cortisol is a valuable indicator of the activity of the hypothalamic‐pituitary‐adrenocortical axis, which is known to be altered in psychiatric disorders. Measurements of salivary cortisol helped to reveal changes that would otherwise remained undetected, such as increase in cortisol release in spontaneously occurring panic attacks. By selecting only the subjects with high and low trait anxiety, we have brought evidence confirmed by others that high trait anxiety may be associated with an inability to respond with adequate cortisol release during stress. Papers on the relationship between salivary dehydroepiandrosterone and trait anxiety or anxiety disorders are rare, and this stress hormone deserves more attention. Almost nothing is known on aldosterone and anxiety. We have modified the methodology of aldosterone radioimmunoassay by concentrating the saliva and validated it biologically by demonstrating daily variation and gender differences. We have provided the first data on the relationship between aldosterone and trait anxiety. Obtained results show a significant negative correlation between morning salivary aldosterone concentrations and trait anxiety scores in women (luteal phase), but not in men. A more proper elucidation of the association between aldosterone and anxiety seems to be an important target of further research.
    Type of Medium: Online Resource
    ISSN: 0077-8923 , 1749-6632
    URL: Issue
    URL: Article
    DOI: 10.1196/nyas.2008.1148.issue-1
    DOI: 10.1196/annals.1410.050
    RVK:
    TD 7650
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2834079-6
    detail.hit.zdb_id: 211003-9
    detail.hit.zdb_id: 2071584-5
    SSG: 11
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  • 5
    Online Resource
    Online Resource
    Psychotropic Drug Effects on Steroid Stress Hormone Release and Possible Mechanisms Involved
    MDPI AG ; 2022
    In:  International Journal of Molecular Sciences Vol. 23, No. 2 ( 2022-01-14), p. 908-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 2 ( 2022-01-14), p. 908-
    Abstract: There is no doubt that chronic stress accompanied by adrenocortical stress hormone release affects the development and treatment outcome of several mental disorders. Less attention has been paid to the effects of psychotropic drugs on adrenocortical steroids, particularly in clinical studies. This review focuses on the knowledge related to the possible modulation of cortisol and aldosterone secretion under non-stress and stress conditions by antipsychotic drugs, which are being used in the treatment of several psychotic and affective disorders. The molecular mechanisms by which antipsychotic drugs may influence steroid stress hormones include the modulation of central and/or adrenocortical dopamine and serotonin receptors, modulation of inflammatory cytokines, influence on regulatory mechanisms in the central part of the hypothalamic-pituitary axis, inhibition of corticotropin-releasing hormone gene promoters, influencing glucocorticoid receptor-mediated gene transcription, indirect effects via prolactin release, alteration of signaling pathways of glucocorticoid and mineralocorticoid actions. Clinical studies performed in healthy subjects, patients with psychosis, and patients with bipolar disorder suggest that single and repeated antipsychotic treatments either reduce cortisol concentrations or do not affect its secretion. A single and potentially long-term treatment with dopamine receptor antagonists, including antipsychotics, has a stimulatory action on aldosterone release.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms23020908
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models
    American Society for Pharmacology & Experimental Therapeutics (ASPET) ; 2018
    In:  Drug Metabolism and Disposition Vol. 46, No. 6 ( 2018-06), p. 913-923
    Details
    In: Drug Metabolism and Disposition, American Society for Pharmacology & Experimental Therapeutics (ASPET), Vol. 46, No. 6 ( 2018-06), p. 913-923
    Type of Medium: Online Resource
    ISSN: 0090-9556 , 1521-009X
    URL: Article
    DOI: 10.1124/dmd.117.079582
    Language: English
    Publisher: American Society for Pharmacology & Experimental Therapeutics (ASPET)
    Publication Date: 2018
    detail.hit.zdb_id: 1500213-5
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Brain derived neurotrophic factor expression and DNA methylation in response to subchronic valproic acid and/or aldosterone treatment
    Croatian Medical Journals ; 2019
    In:  Croatian Medical Journal Vol. 60, No. 2 ( 2019-4), p. 71-77
    Details
    In: Croatian Medical Journal, Croatian Medical Journals, Vol. 60, No. 2 ( 2019-4), p. 71-77
    Type of Medium: Online Resource
    ISSN: 0353-9504 , 1332-8166
    URL: Article
    DOI: 10.3325/cmj.2019.60.71
    Language: Unknown
    Publisher: Croatian Medical Journals
    Publication Date: 2019
    detail.hit.zdb_id: 2030122-4
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  • 8
    Online Resource
    Online Resource
    β 3 -Adrenergic receptors, adipokines and neuroendocrine activation during stress induced by repeated immune challenge in male and female rats
    Informa UK Limited ; 2017
    In:  Stress Vol. 20, No. 3 ( 2017-05-04), p. 294-302
    Details
    In: Stress, Informa UK Limited, Vol. 20, No. 3 ( 2017-05-04), p. 294-302
    Type of Medium: Online Resource
    ISSN: 1025-3890 , 1607-8888
    URL: Article
    DOI: 10.1080/10253890.2017.1320387
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2030639-8
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Effect of blockade of mGluR5 on stress hormone release and its gene expression in the adrenal gland
    Canadian Science Publishing ; 2014
    In:  Canadian Journal of Physiology and Pharmacology Vol. 92, No. 8 ( 2014-08), p. 686-692
    Details
    In: Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 92, No. 8 ( 2014-08), p. 686-692
    Abstract: The aim of this study was to verify the presence of metabotropic glutamate receptor subtype 5 (mGluR5) in the adrenal gland of male rats of 2 different strains, and to test the hypothesis that treatment with mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) affects hormone release and adrenal gene expression of mGluR5 under conditions of stress. The results clearly show the gene expression of mGluR5 in the adrenal gland in both the adrenal cortex and medulla. Treatment with the glutamate release inhibitor riluzole (4 mg·(kg body mass) –1 ·day –1 for 2 weeks) failed to modify mRNA levels of either the mGluR5 or NR1 subunit of the NMDA receptor in the adrenal glands, as measured by real-time PCR. Blockade of mGluR5 with MPEP (1 mg·kg –1 for 4 days) increased corticosterone but not catecholamine release during restraint stress (20 min). Treatment with MPEP had no effect on mRNA levels coding for steroidogenic factors StAR and SF-1, and decreased mGluR5 gene expression in the adrenal gland. In conclusion, mGluR5 is not likely to play a significant role in stress-induced catecholamine release. Pharmacological blockade of mGluR5 has a modest influence on the hypothalamic–pituitary–adrenocortical axis, as reflected in adrenal hypertrophy and increased corticosterone concentrations.
    Type of Medium: Online Resource
    ISSN: 0008-4212 , 1205-7541
    URL: Article
    DOI: 10.1139/cjpp-2014-0030
    Language: English
    Publisher: Canadian Science Publishing
    Publication Date: 2014
    detail.hit.zdb_id: 2004356-9
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  • 10
    Online Resource
    Online Resource
    Attenuated Neuroendocrine Response to Hypoglycemic Stress in Patients with Panic Disorder
    S. Karger AG ; 2010
    In:  Neuroendocrinology Vol. 92, No. 2 ( 2010), p. 112-119
    Details
    In: Neuroendocrinology, S. Karger AG, Vol. 92, No. 2 ( 2010), p. 112-119
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 There is a lack of information on the effects of metabolic stress exposure on hormone release in patients with panic disorder. The aim of this study was to test the hypothesis that neuroendocrine activation during hypoglycemic stress is altered in panic disorder patients compared to healthy subjects. 〈 i 〉 Methods: 〈 /i 〉 Hormone responses to an intravenous bolus of insulin (0.1 IU/kg) were evaluated in both fully remitted, medication-free panic disorder patients and healthy controls (n = 9/group). Blood samples for determination of cortisol, growth hormone, prolactin, adrenaline and noradrenaline concentrations were obtained at rest and over a 90-min period after insulin injection. 〈 i 〉 Results: 〈 /i 〉 In patients with panic disorder, basal prestress hormone levels were comparable to those in healthy subjects with the exception of plasma adrenaline, which was higher in panic disorder patients compared to controls. The degree of hypoglycemia induced by insulin administration was similar in patients and healthy subjects. Hypoglycemia-induced increases in growth hormone, prolactin and cortisol concentrations were significantly attenuated in panic disorder patients compared to healthy individuals. No differences between patients and controls were observed in adrenalin release induced by hypoglycemia. 〈 i 〉 Conclusions: 〈 /i 〉 The present data demonstrate that somatotropic, lactotropic and corticotropic activation during hypoglycemic stress is blunted in patients with panic disorder. It is suggested that in contrast to the effects of relatively mild stress conditions used in other studies published in the literature, intensive stressors inducing a broad spectrum of hormonal changes fail to provoke an adequate neuroendocrine response in patients with panic disorder.
    Type of Medium: Online Resource
    ISSN: 0028-3835 , 1423-0194
    URL: Article
    DOI: 10.1159/000283560
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1483028-0
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