In:
The Journal of Bone and Joint Surgery. British volume, British Editorial Society of Bone & Joint Surgery, Vol. 36-B, No. 4 ( 1954-11), p. 543-552
Abstract:
The method of producing osteogenic sarcoma in rabbits by the injection of beryllium in the form of "zinc beryllium silicate" is presented. In five of ten animals which had such injections, osteogenic sarcomas developed several months later. There was new bone formation in the medullary cavities of the long bones before malignant changes were apparent. It is of particular interest to note that there was atrophy of the spleen in those animals in which bone tumours developed, whereas the spleen seemed to be quite normal in the rabbits which did not develop bone tumours. The tumours usually developed in the metaphysial regions. More than one tumour often developed in the same animal.
Type of Medium:
Online Resource
ISSN:
0301-620X
,
2044-5377
DOI:
10.1302/0301-620X.36B4.543
Language:
English
Publisher:
British Editorial Society of Bone & Joint Surgery
Publication Date:
1954
detail.hit.zdb_id:
2697480-0
detail.hit.zdb_id:
2039886-4
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