In:
International Journal of Urology, Wiley, Vol. 15, No. 7 ( 2008-07), p. 642-645
Abstract:
Abstract: The objective was to investigate cardiovascular complications in long‐term survivors treated by high‐dose chemotherapy. We analyzed 13 previously successfully treated metastatic germ cell cancer patients. The patients ranged in age from 16 to 38 years (median: 27 years). Patients were treated by high‐dose ifosfamide, carboplatin and etoposide (ICE) or high‐dose etoposide, ifosfamide and cisplatin (VIP). In a minimal follow‐up of 48 months, the incidence of cardiovascular events and the accumulated doses of platinum were analyzed from the total amounts of cisplatin and/or carboplatin. The calculated accumulated doses of platinum ranged from 487 to 4302 mg (median: 2297 mg). Cardiovascular events were observed in two patients who received cumulative doses of more than 3000 mg of platinum. Survivors of high‐dose chemotherapy may have a risk of developing cardiovascular complications during the early phase of follow‐up. In particular, patients who have received carboplatin‐based high dose chemotherapy require careful observation.
Type of Medium:
Online Resource
ISSN:
0919-8172
,
1442-2042
DOI:
10.1111/iju.2008.15.issue-7
DOI:
10.1111/j.1442-2042.2008.02066.x
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2009793-1
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