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  • 1
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    Online Resource
    Biomarker levels in peri‐implant crevicular fluid of healthy implants, untreated and non‐surgically treated implants with peri‐implantitis
    Wiley ; 2021
    In:  Journal of Clinical Periodontology Vol. 48, No. 4 ( 2021-04), p. 590-601
    Details
    In: Journal of Clinical Periodontology, Wiley, Vol. 48, No. 4 ( 2021-04), p. 590-601
    Abstract: To compare biomarker levels in peri‐implant crevicular fluid (PICF) of healthy implants with levels in PICF of implants with peri‐implantitis (before and after non‐surgical treatment). Materials and methods Samples were taken from 20 healthy implants ( n  = 17 patients) and from 20 implants with peri‐implantitis ( n  = 19 patients) before and 3 months after non‐surgical treatment using the Airflow Master Piezon ® (EMS). A Luminex™ assay was used to evaluate pro‐inflammatory and anti‐inflammatory cytokines IL‐1β, TNF‐α, IL‐6 and G‐CSF, collagen degradation enzyme MMP‐8, chemokines MCP‐1 & MIP‐1α/CCL3, bone markers OPG and sRANKL and interferon‐γ. Clinical and radiographical characteristics were assessed. A Mann–Whitney U and Wilcoxon signed‐rank test analysed between‐ and within‐group differences. Results IL‐1β and MMP‐8 levels were found significantly elevated in implants with peri‐implantitis ( p  = .007; p  =  〈 .001, respectively). No difference in levels of TNF‐α, IL‐6, MCP‐1 and MIP‐1α/CCL3, OPG and G‐CSF between healthy and diseased implants was found. Levels of sRANKL and INF‐γ were under the level of detection. None of the biomarker levels improved after non‐surgical therapy, and levels of IL‐1β and MMP‐8 remained high. Conclusion Implants diagnosed with peri‐implantitis have higher levels of IL‐1β and MMP‐8 in PICF compared to healthy implants. Non‐surgical therapy did not influence the inflammatory immune response.
    Type of Medium: Online Resource
    ISSN: 0303-6979 , 1600-051X
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpe.v48.4
    DOI: 10.1111/jcpe.13423
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2026349-1
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  • 2
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    Implant decontamination with phosphoric acid during surgical peri-implantitis treatment: a RCT
    Springer Science and Business Media LLC ; 2017
    In:  International Journal of Implant Dentistry Vol. 3, No. 1 ( 2017-12)
    Details
    In: International Journal of Implant Dentistry, Springer Science and Business Media LLC, Vol. 3, No. 1 ( 2017-12)
    Type of Medium: Online Resource
    ISSN: 2198-4034
    URL: Article
    DOI: 10.1186/s40729-017-0091-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2842869-9
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  • 3
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    Non‐surgical peri‐implantitis treatment using a pocket irrigator device; clinical, microbiological, radiographical and patient‐centred outcomes—A pilot study
    Wiley ; 2020
    In:  International Journal of Dental Hygiene Vol. 18, No. 4 ( 2020-11), p. 403-412
    Details
    In: International Journal of Dental Hygiene, Wiley, Vol. 18, No. 4 ( 2020-11), p. 403-412
    Abstract: The aim of this prospective cohort study was to assess the effect of a pocket irrigator/evacuator device (IED) in the non‐surgical treatment of peri‐implantitis. Material and Methods In total 24 patients having 38 implants diagnosed with peri‐implantitis were included in this study. Peri‐implant pockets were irrigated six times in three consecutive weeks. The primary outcome was bleeding on probing (BoP). Secondary outcome parameters included plaque index (Pl), suppuration on probing (SoP), probing pocket depth (PPD), marginal bone loss (MBL), presence and numbers of periodontal pathogens. Parameters were assessed at baseline and 3 months after the last treatment. Treatment pain perception was scored using the visual analog scale (VAS) after the first and last treatment. Results At 3 months, IED treatment revealed significant reduction of peri‐implant BoP (71% [±20] vs 57% [±28] [ P  = .014]) and peri‐implant plaque scores (10 [±14] to 5 [±9] [ P =  .039] [T0 vs T3 respectively] ). Significant reduction in mean peri‐implant PPD from 4.92 mm (SD ± 1.28) to 4.66 mm (SD ± 1.35) ( P  = .041) was observed. In addition, a reduction in VAS pain score between the first and the last (6th) treatment was found ( P  = .039). No reduction in SoP ( P  = .088) was found. No changes in mean periodontal full mouth plaque, BOP, SOP and PPD levels, MBL and microbiological outcomes were found. Conclusion Beneficial clinical effects in terms of BoP, PPD and PI were found at 3 months after IED treatment. However, the IED does not seem to effectively treat peri‐implantitis in terms of disease resolution.
    Type of Medium: Online Resource
    ISSN: 1601-5029 , 1601-5037
    URL: Issue
    URL: Article
    DOI: 10.1111/idh.v18.4
    DOI: 10.1111/idh.12462
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2106535-4
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  • 4
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    Erythritol airpolishing in the non‐surgical treatment of peri‐implantitis: A randomized controlled trial
    Wiley ; 2021
    In:  Clinical Oral Implants Research Vol. 32, No. 7 ( 2021-07), p. 840-852
    Details
    In: Clinical Oral Implants Research, Wiley, Vol. 32, No. 7 ( 2021-07), p. 840-852
    Abstract: To compare erythritol air polishing with piezoelectric ultrasonic scaling in the non‐surgical treatment of peri‐implantitis. Material and methods Eighty patients ( n  = 139 implants) with peri‐implantitis (probing pocket depth (PPD) ≥5 mm, marginal bone loss (MBL) ≥2 mm as compared to bone level at implant placement, bleeding, and/or suppuration on probing (BoP/SoP)) were randomly allocated to air polishing or ultrasonic treatment. The primary outcome was mean BoP (%) at 3 months after therapy (T3). Secondary outcomes were mean SoP (%), plaque score (Plq) (%), PPD (mm), MBL (mm), full mouth periodontal scores (FMPS) (%), levels of 8 classical periodontal pathogens, and treatment pain/discomfort (Visual Analog Scale, VAS). Patients who were considered successful at T3 were additionally assessed at 6, 9, and 12 months. Differences between both groups were analyzed using multilevel statistics. Results Three months after therapy, no significant difference in mean BoP (%) between the air polishing and ultrasonic therapy was found (crude analysis β (95% CI) −0.037 (−0.147; 0.073), p  = .380). Neither secondary outcomes SoP (%), Plq (%), PPD (mm), MBL (mm), FMPS (%), and periodontal pathogens showed significant differences. Treatment pain/discomfort was low in both groups (VAS score airpolishing group 2.1 (±1.9), ultrasonic 2.6 (±1.9); p  = .222). All successfully treated patients at T3 (18.4%) were still considered successful at 12‐month follow‐up. Conclusions Erythritol air polishing seems as effective as piezoelectric ultrasonic scaling in the non‐surgical treatment of peri‐implantitis, in terms of clinical, radiographical, and microbiological parameters. However, neither of the proposed therapies effectively resolved peri‐implantitis. Hence, the majority of patients required further surgical treatment.
    Type of Medium: Online Resource
    ISSN: 0905-7161 , 1600-0501
    URL: Issue
    URL: Article
    DOI: 10.1111/clr.v32.7
    DOI: 10.1111/clr.13757
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2027104-9
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  • 5
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    Immediate implant placement with immediate or delayed provisionalization in the maxillary aesthetic zone: A 10‐year randomized trial
    Wiley ; 2024
    In:  Journal of Clinical Periodontology
    Details
    In: Journal of Clinical Periodontology, Wiley
    Abstract: To compare the marginal bone level of immediately placed implants, with either immediate or delayed provisionalization (IP or DP), in the maxillary aesthetic zone after 10 years of function. Materials and Methods Participants with a failing tooth in the maxillary aesthetic zone were randomly assigned to immediate implant placement with either IP ( n = 20) or DP ( n = 20) after primary wound closure with a free gingival graft. The final restoration was placed 3 months after provisionalization. The primary outcome was change in marginal bone level. In addition, implant survival, restoration survival and success, peri‐implant tissue health, mucosa levels, aesthetic indices, buccal bone thickness and patient satisfaction were evaluated. Results After 10 years, the mean mesial and distal changes in marginal bone level were −0.47 ± 0.45 mm and −0.49 ± 0.52 mm in the IP group and −0.58 ± 0.76 mm and −0.41 ± 0.72 mm in the DP group ( p = .61; p = .71). The survival rate was 100% for the implants; for the restorations, it was 88.9% in the IP group and 87.5% in the DP group. Restoration success, according to modified USPHS criteria, was 77.8% in the IP group and 75.0% in the DP group. The prevalence of peri‐implant mucositis was 38.9% and 35.7% and of peri‐implantitis 0.0% and 6.3%, respectively, in the IP group and DP group ( p = 1.0; p = .40). The Pink Esthetic Score and White Esthetic Score was 15.28 ± 2.32 in the IP group and 14.64 ± 2.74 in the DP group, both clinically acceptable ( p = .48). The buccal bone thickness was lower in the DP group. Patient satisfaction was similar in both groups ( p = .75). Conclusions The mean marginal bone level changes after immediate implant placement with IP were similar to those after immediate placement with DP. Clinical Trial Registration Registered in the National Trial Register (NL9340).
    Type of Medium: Online Resource
    ISSN: 0303-6979 , 1600-051X
    URL: Article
    DOI: 10.1111/jcpe.13971
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2026349-1
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  • 6
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    Immediate placement of single implants with or without immediate provisionalization in the maxillary aesthetic region: A 5‐year comparative study
    Wiley ; 2021
    In:  Journal of Clinical Periodontology Vol. 48, No. 2 ( 2021-02), p. 272-283
    Details
    In: Journal of Clinical Periodontology, Wiley, Vol. 48, No. 2 ( 2021-02), p. 272-283
    Abstract: To compare marginal bone level changes around immediately placed and immediately provisionalized implants with immediately placed and delayed provisionalized implants in the aesthetic region after five years of function. Materials and Methods Forty patients with a failing tooth in the maxillary anterior region were randomly assigned immediate implant placement with immediate (Group A: n  = 20) or delayed (Group B: n  = 20) provisionalization. Definitive crown placement occurred three months after provisionalization. The primary outcomes were changes in marginal bone level. In addition, survival rates, buccal bone thickness, soft peri‐implant tissues, aesthetics and patient‐reported outcomes were assessed. Results After 5 years, the mean mesial and distal marginal bone level changes were 0.71 ± 0.68 mm and 0.71 ± 0.71 mm, respectively, in group A and 0.49 ± 0.52 mm and 0.54 ± 0.64 mm, respectively, in group B; the difference between the groups was not significant ( p  = .305 and p  = .477, respectively). Implant and restoration survivals were 100%. No clinically relevant differences in buccal bone thickness or in mid‐facial peri‐implant mucosal level, aesthetic and patient outcomes were observed. Conclusions The mean marginal bone level changes following immediate implant placement and provisionalization were comparable with immediate implant placement and delayed provisionalization. ( www.isrctn.com : ISRCTN57251089 and www.trialregister.nl : NL8255).
    Type of Medium: Online Resource
    ISSN: 0303-6979 , 1600-051X
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpe.v48.2
    DOI: 10.1111/jcpe.13398
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 7
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    Immediate single‐tooth implant placement with simultaneous bone augmentation versus delayed implant placement after alveolar ridge preservation in bony defect sites in the esthetic region: A 5‐year randomized controlled trial
    Wiley ; 2021
    In:  Journal of Periodontology Vol. 92, No. 12 ( 2021-12), p. 1738-1748
    Details
    In: Journal of Periodontology, Wiley, Vol. 92, No. 12 ( 2021-12), p. 1738-1748
    Abstract: It is unclear if an intact buccal bony plate is a prerequisite for immediate implant placement in post‐extraction sockets. The aim of this 5‐year randomized controlled trial was therefore comparison of peri‐implant soft and hard tissue parameters, esthetic ratings, and patient‐reported satisfaction of immediate implant placement in post‐extraction sockets with buccal bony defects of ≥ 5 mm in the esthetic zone, with delayed implant placement after ridge preservation. Methods Patients presenting a failing tooth in the esthetic region and a buccal bony defect of ≥ 5 mm after extraction were randomly assigned to immediate (Immediate group, n  = 20) or delayed (Delayed group, n  = 20) implant placement. Second‐stage surgery and placement of a provisional restoration occurred 3 months after implant placement in both groups, followed by definitive restorations 3 months thereafter. The follow‐up was 5 years. Marginal bone level (primary outcome), buccal bone thickness, soft tissue parameters, esthetics, and patient‐reported satisfaction were recorded. Results Mean marginal bone level change was −0.71 ± 0.35 mm and −0.54 ± 0.41 mm in respectively the Immediate group and the Delayed group after 5 years ( P  = 0.202). This difference, and in other variables, was not significant. Conclusions Marginal bone level changes, buccal bone thickness, clinical outcomes, esthetics, and patients’ satisfaction following immediate implant placement, in combination with bone augmentation in post‐extraction sockets with buccal bony defects of ≥ 5 mm, were comparable to those following delayed implant placement after ridge preservation in the esthetic zone.
    Type of Medium: Online Resource
    ISSN: 0022-3492 , 1943-3670
    URL: Issue
    URL: Article
    DOI: 10.1002/jper.v92.12
    DOI: 10.1002/JPER.20-0845
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2040047-0
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