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  • 1
    In: Ophthalmology and Therapy, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2023-02), p. 401-429
    Type of Medium: Online Resource
    ISSN: 2193-8245 , 2193-6528
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
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  • 2
    In: Atmospheric Chemistry and Physics, Copernicus GmbH, Vol. 16, No. 17 ( 2016-08-31), p. 10831-10845
    Abstract: Abstract. The 2014–2015 Holuhraun lava-flood eruption of Bárðarbunga volcano (Iceland) emitted prodigious amounts of sulfur dioxide into the atmosphere. This eruption caused a large-scale episode of air pollution throughout Western Europe in September 2014, the first event of this magnitude recorded in the modern era. We gathered chemistry-transport simulations and a wealth of complementary observations from satellite sensors (OMI, IASI), ground-based remote sensing (lidar, sunphotometry, differential optical absorption spectroscopy) and ground-level air quality monitoring networks to characterize both the spatial-temporal distributions of volcanic SO2 and sulfate aerosols as well as the dynamics of the planetary boundary layer. Time variations of dynamical and microphysical properties of sulfate aerosols in the aged low-tropospheric volcanic cloud, including loading, vertical distribution, size distribution and single scattering albedo, are provided. Retrospective chemistry-transport simulations at low horizontal resolution (25 km  ×  25 km) capture the correct temporal dynamics of this far-range air pollution event but fail to reproduce the correct magnitude of SO2 concentration at ground-level. Simulations at higher spatial resolution, relying on two nested domains with finest resolution of 7.3 km  ×  7.3 km, improve substantially the far-range vertical distribution of the volcanic cloud and subsequently the description of ground-level SO2 concentrations. However, remaining discrepancies between model and observations are shown to result from an inaccurate representation of the planetary boundary layer (PBL) dynamics. Comparison with lidar observations points out a systematic under-estimation of the PBL height by the model, whichever the PBL parameterization scheme. Such a shortcoming impedes the capture of the overlying Bárðarbunga cloud into the PBL at the right time and in sufficient quantities. This study therefore demonstrates the key role played by the PBL dynamics in accurately modelling large-scale volcanogenic air pollution.
    Type of Medium: Online Resource
    ISSN: 1680-7324
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2016
    detail.hit.zdb_id: 2092549-9
    detail.hit.zdb_id: 2069847-1
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  • 3
    In: Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 134, No. 2 ( 2024-01-19), p. 189-202
    Abstract: Diabetes is a major risk factor for atherosclerotic cardiovascular diseases with a 2-fold higher risk of cardiovascular events in people with diabetes compared with those without. Circulating monocytes are inflammatory effector cells involved in both type 2 diabetes (T2D) and atherogenesis. METHODS: We investigated the relationship between circulating monocytes and cardiovascular risk progression in people with T2D, using phenotypic, transcriptomic, and metabolomic analyses. cardiovascular risk progression was estimated with coronary artery calcium score in a cohort of 672 people with T2D. RESULTS: Coronary artery calcium score was positively correlated with blood monocyte count and frequency of the classical monocyte subtype. Unsupervised k-means clustering based on monocyte subtype profiles revealed 3 main endotypes of people with T2D at varying risk of cardiovascular events. These observations were confirmed in a validation cohort of 279 T2D participants. The predictive association between monocyte count and major adverse cardiovascular events was validated through an independent prospective cohort of 757 patients with T2D. Integration of monocyte transcriptome analyses and plasma metabolomes showed a disruption of mitochondrial pathways (tricarboxylic acid cycle, oxidative phosphorylation pathway) that underlined a proatherogenic phenotype. CONCLUSIONS: In this study, we provide evidence that frequency and monocyte phenotypic profile are closely linked to cardiovascular risk in patients with T2D. The assessment of monocyte frequency and count is a valuable predictive marker for risk of cardiovascular events in patients with T2D. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04353869
    Type of Medium: Online Resource
    ISSN: 0009-7330 , 1524-4571
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
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  • 4
    In: Atmospheric Measurement Techniques, Copernicus GmbH, Vol. 14, No. 12 ( 2021-12-10), p. 7775-7807
    Abstract: Abstract. We present the first global glyoxal (CHOCHO) tropospheric column product derived from the TROPOspheric Monitoring Instrument (TROPOMI) on board the Sentinel-5 Precursor satellite. Atmospheric glyoxal results from the oxidation of other non-methane volatile organic compounds (NMVOCs) and from direct emissions caused by combustion processes. Therefore, this product is a useful indicator of VOC emissions. It is generated with an improved version of the BIRA-IASB scientific retrieval algorithm relying on the differential optical absorption spectroscopy (DOAS) approach. Among the algorithmic updates, the DOAS fit now includes corrections to mitigate the impact of spectral misfits caused by scene brightness inhomogeneity and strong NO2 absorption. The product comes along with a full error characterization, which allows for providing random and systematic error estimates for every observation. Systematic errors are typically in the range of 1 ×1014–3 ×1014 molec. cm−2 (∼30 %–70 % in emission regimes) and originate mostly from a priori data uncertainties and spectral interferences with other absorbing species. The latter may be at the origin, at least partly, of an enhanced glyoxal signal over equatorial oceans, and further investigation is needed to mitigate them. Random errors are large (〉6×1014 molec. cm−2) but can be reduced by averaging observations in space and/or time. Benefiting from a high signal-to-noise ratio and a large number of small-size observations, TROPOMI provides glyoxal tropospheric column fields with an unprecedented level of detail. Using the same retrieval algorithmic baseline, glyoxal column data sets are also generated from the Ozone Monitoring Instrument (OMI) on Aura and from the Global Ozone Monitoring Experiment-2 (GOME-2) on board Metop-A and Metop-B. Those four data sets are intercompared over large-scale regions worldwide and show a high level of consistency. The satellite glyoxal columns are also compared to glyoxal columns retrieved from ground-based Multi-AXis DOAS (MAX-DOAS) instruments at nine stations in Asia and Europe. In general, the satellite and MAX-DOAS instruments provide consistent glyoxal columns both in terms of absolute values and variability. Correlation coefficients between TROPOMI and MAX-DOAS glyoxal columns range between 0.61 and 0.87. The correlation is only poorer at one mid-latitude station, where satellite data appear to be biased low during wintertime. The mean absolute glyoxal columns from satellite and MAX-DOAS generally agree well for low/moderate columns with differences of less than 1×1014 molec. cm−2. A larger bias is identified at two sites where the MAX-DOAS columns are very large. Despite this systematic bias, the consistency of the satellite and MAX-DOAS glyoxal seasonal variability is high.
    Type of Medium: Online Resource
    ISSN: 1867-8548
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    ASME International ; 2015
    In:  Journal of Engineering for Gas Turbines and Power Vol. 137, No. 9 ( 2015-09-01)
    In: Journal of Engineering for Gas Turbines and Power, ASME International, Vol. 137, No. 9 ( 2015-09-01)
    Abstract: Due to the increasing fuel cost and environmental targets, the demand for more efficient gas turbines has risen considerably in the last decade. One of the most important systems in a gas turbine is the secondary air system, which provides cooling air to the disks and to the blades. It also provides air for sealing of the bearing chambers. The amount of secondary air that is extracted from the compressor is a performance penalty for the engine. In aero engines, bearing chambers are in most cases sealed by the most traditional type of seal, the labyrinth seal. Bearing chambers contain the oil lubricated components like bearings and gears. In order to avoid oil migration from the bearing chamber into the turbomachinery, the seals are pressurized by secondary air; thus, a pressure difference is setup across the seal, which retains the lubricant into the bearing chamber. Oil loss can lead to a number of problems like oil fire or coking with the probability of an uncontained destruction of the aero engine. Oil fumes can also cause contamination of the air conditioning system of the aircraft thus cause discomfort to the passengers. Beside labyrinth seals, other types of seals such as brush seals and carbon seals are used. Both the latter are contact type seals, that is, they may be installed with zero gap and lift during operation when they get pressurized. Brush seals particularly may be installed having an overlap with the rotating part. An original aero engine bearing chamber was modified by MTU Aero Engines to run with brush seals in a simulating rig in Munich. Two types of brush seals were used for testing: (a) a brush seal with bristles made of Kevlar fibers and (b) a brush seal with bristles made of steel. Both types were installed with an overlap to the rotor. The targets set were twofold: (a) to measure the transient temperatures in the rotor and particularly in the contact zone between the bristles and the rotor and (b) to calculate the heat generation by the seals which could enable predictions of the heat generation in future applications (i.e., scaling to bigger rotor diameters). For the heat transfer calculations, numerical models using ansys cfx were created. Additionally, a coupled computational fluid dynamics (CFD) and finite element analysis (FEA) approach was applied to simulate flow and bristle's behavior. In order to obtain the transient temperature measurements with high fidelity, a new pyrometric technique was developed and was applied for the first time in brush seals as reported by Flouros et al. (2013, “Transient Temperature Measurements in the Contact Zone Between Brush Seals of Kevlar and Metallic Type for Bearing Chamber Sealing Using a Pyrometric Technique,” ASME J. Gas Turbines Power, 135(8), p. 081603) and Flouros et al. (2012, “Transient Temperature Measurements in the Contact Zone Between Brush Seals of Kevlar and Metallic Type for Bearing Chamber Sealing Using a Pyrometric Technique,” ASME Turbo Expo 2012, Copenhagen, Paper No. GT2012-68354). This technique has enabled positioning of the pyrometer (SensorthermGmbH, www.sensortherm.com) into the bristles pack of the seal adjacent to the rotating surface. The pyrometer could record the frictional temperature evolution in the bristles/rotor contact zone during accelerations or decelerations of the rotor. The sealing air demand can be reduced up to 97% with brush seals compared to traditional three fin labyrinth. It has been estimated that this can result in a reduction in fuel burned up to 1%. Further, the reduction in air flow has additional potential benefits such as a possible simplification of the bearing chamber architecture (vent less chamber). Even though the rotor was accelerated up to 19,500 rpm, the temperature induced overshoots in the seal/rotor contact zone have caused no deterioration in either the materials or the oil.
    Type of Medium: Online Resource
    ISSN: 0742-4795 , 1528-8919
    Language: English
    Publisher: ASME International
    Publication Date: 2015
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  • 6
    In: Intensive Care Medicine Experimental, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2021-12)
    Abstract: Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by preclinical models of the complex human condition of sepsis, bias in preclinical studies, as well as limitations of single-laboratory methodology. To overcome some of these shortcomings, multicentre preclinical studies—defined as a research experiment conducted in two or more research laboratories with a common protocol and analysis—are expected to maximize transparency, improve reproducibility, and enhance generalizability. The ultimate objective is to increase the efficiency and efficacy of bench-to-bedside translation for preclinical sepsis research and improve outcomes for patients with life-threatening infection. To this end, we organized the first meeting of the National Preclinical Sepsis Platform (NPSP). This multicentre preclinical  research collaboration of Canadian sepsis researchers and stakeholders was established to study the pathophysiology of sepsis and accelerate movement of promising therapeutics into early phase clinical trials. Integrated knowledge translation and shared decision-making were emphasized to ensure the goals of the platform align with clinical researchers and patient partners. 29 participants from 10 independent labs attended and discussed four main topics: (1) objectives of the platform; (2) animal models of sepsis; (3) multicentre methodology and (4) outcomes for evaluation. A PIRO model (predisposition, insult, response, organ dysfunction) for experimental design was proposed to strengthen linkages with interdisciplinary researchers and key stakeholders. This platform represents an important resource for maximizing translational impact of preclinical sepsis research.
    Type of Medium: Online Resource
    ISSN: 2197-425X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2740385-3
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  • 7
    Online Resource
    Online Resource
    ASME International ; 2011
    In:  Journal of Engineering for Gas Turbines and Power Vol. 133, No. 6 ( 2011-06-01)
    In: Journal of Engineering for Gas Turbines and Power, ASME International, Vol. 133, No. 6 ( 2011-06-01)
    Abstract: The Aero-Thermo-Mechanics (ATM) Department of ULB (Université Libre de Bruxelles) is developing an original system to pump and separate a two-phase flow. Many applications need to extract a certain phase of a multiphase flow: oil extraction, flow in nuclear pumps, flow in aircraft lubrication systems, pulp and paper processing, etc. The main objective of this study is to obtain a lightweight, compact, and efficient system that can both extract the gas of a two-phase flow and increase the pressure of the liquid phase. Prototypes with different designs were first tested at ULB on a specific test bench using water and air. The current prototype is a kind of axial-centrifugal pump. The axial part is used to separate the two phases of the flow and to collect, in the centrifugal part, the liquid phase only. The test results of the water-air prototypes have allowed to identify the key design and working parameters for efficient separation and pumping. A theoretical model has also been developed to describe the behavior of these prototypes. After successful tests with water-air mixtures, the technology has been implemented for a hot oil-air mixture. The tests with oil-air mixtures are performed on the aeroengine lubrication system test bench that the ATM Department developed and continues developing for other projects. At the same time, the flow field in the pump and separator system is being studied with commercial computational fluid dynamics software packages. Several two-phase flow models are considered for this particular application.
    Type of Medium: Online Resource
    ISSN: 0742-4795 , 1528-8919
    Language: English
    Publisher: ASME International
    Publication Date: 2011
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    detail.hit.zdb_id: 165371-4
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  • 8
    In: Journal of Atmospheric and Oceanic Technology, American Meteorological Society, ( 2021-05-25)
    Abstract: We present the first ground-based remote sensing measurements of NO 2 made in Kinshasa. They were performed from 2017 to 2019. The motivation of making observations on air pollution in Kinshasa comes from its geographical location, its demography, its climatic conditions and the many different sources of NO 2 existing in its surroundings. A method for recovering the vertical density of the NO 2 tropospheric column (VCDtropo) based on the Differential Optical Absorption Spectroscopy (DOAS) applied to observations at the zenith and 35° elevation angle is described. The mean value of VCDtropo observed in Kinshasa is 3 × 10 15 molecules cm −2 . We further present first comparisons with the OMI and TROPOMI satellite observations. When comparing OMI data with our observations and using a linear regression analysis, we find a slope of 0.34 and a correlation coefficient of 0.50 for 51 days of coincidences over 2017−2019. Similar comparisons with TROPOMI for 44 days show a slope of 0.41 and a correlation coefficient of 0.72. This study opens up perspectives for further air quality related studies in Kinshasa and central Africa.
    Type of Medium: Online Resource
    ISSN: 0739-0572 , 1520-0426
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2021
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    detail.hit.zdb_id: 48441-6
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  • 9
    In: Nature, Springer Science and Business Media LLC, Vol. 488, No. 7409 ( 2012-8), p. 49-56
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    RVK:
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    RVK:
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
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    detail.hit.zdb_id: 1413423-8
    SSG: 11
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  • 10
    Online Resource
    Online Resource
    Elsevier BV ; 1988
    In:  European Journal of Medicinal Chemistry Vol. 23, No. 1 ( 1988-1), p. 69-76
    In: European Journal of Medicinal Chemistry, Elsevier BV, Vol. 23, No. 1 ( 1988-1), p. 69-76
    Type of Medium: Online Resource
    ISSN: 0223-5234
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1988
    detail.hit.zdb_id: 2005170-0
    SSG: 15,3
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