In:
Pediatric Blood & Cancer, Wiley, Vol. 68, No. 12 ( 2021-12)
Abstract:
To characterize viscoelastic testing profiles of children with multisystem inflammatory syndrome in children (MIS‐C). Methods This single‐center retrospective review included 30 patients diagnosed with MIS‐C from March 1 to September 1, 2020. Thromboelastography (TEG) with platelet mapping was performed in 19 (63%) patients and compared to age‐ and sex‐matched controls prior to cardiac surgery. Relationships between TEG parameters and inflammatory markers were assessed using correlation. Results Patients with MIS‐C had abnormal TEG results compared to controls, including decreased kinetic ( K ) time (1.1 vs. 1.7 minutes, p 〈 .01), increased alpha angle (75.0° vs. 65.7°, p 〈 .01), increased maximum amplitude (70.8 vs. 58.3 mm, p 〈 .01), and decreased lysis in 30 minutes (Ly30) (1.1% vs. 3.7%, p = .03); consistent with increased clot formation rate and strength, and reduced fibrinolysis. TEG maximum amplitude was moderately correlated with erythrocyte sedimentation rate (ESR) ( r = 0.60, p = .02), initial platelet count ( r = 0.67, p 〈 .01), and peak platelet count ( r = 0.51, p = .03). TEG alpha angle was moderately correlated with peak platelet count ( r = 0.54, p = .02). Seventeen (57%) patients received aspirin (ASA) and anticoagulation, five (17%) received only ASA, and three (10%) received only anticoagulation. No patients had a symptomatic thrombotic event. Six (20%) patients had a bleeding event, none of which was major. Conclusions Patients with MIS‐C had evidence of hypercoagulability on TEG. Increased ESR and platelets were associated with higher clot strength. Patients were prophylactically treated with ASA or anticoagulation with no symptomatic thrombosis or major bleeding. Further multicenter study is required to characterize the rate of thrombosis and optimal thromboprophylaxis algorithm in this patient population.
Type of Medium:
Online Resource
ISSN:
1545-5009
,
1545-5017
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2130978-4
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