In:
PLOS Computational Biology, Public Library of Science (PLoS), Vol. 18, No. 8 ( 2022-8-1), p. e1009997-
Abstract:
The relationship between transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the amount of virus present in the proximity of a susceptible host is not understood. Here, we developed a within-host and aerosol mathematical model and used it to determine the relationship between viral kinetics in the upper respiratory track, viral kinetics in the aerosols, and new transmissions in golden hamsters challenged with SARS-CoV-2. We determined that infectious virus shedding early in infection correlates with transmission events, shedding of infectious virus diminishes late in the infection, and high viral RNA levels late in the infection are a poor indicator of transmission. We further showed that viral infectiousness increases in a density dependent manner with viral RNA and that their relative ratio is time-dependent. Such information is useful for designing interventions.
Type of Medium:
Online Resource
ISSN:
1553-7358
DOI:
10.1371/journal.pcbi.1009997
DOI:
10.1371/journal.pcbi.1009997.g001
DOI:
10.1371/journal.pcbi.1009997.g002
DOI:
10.1371/journal.pcbi.1009997.g003
DOI:
10.1371/journal.pcbi.1009997.g004
DOI:
10.1371/journal.pcbi.1009997.g005
DOI:
10.1371/journal.pcbi.1009997.g006
DOI:
10.1371/journal.pcbi.1009997.g007
DOI:
10.1371/journal.pcbi.1009997.t001
DOI:
10.1371/journal.pcbi.1009997.t002
DOI:
10.1371/journal.pcbi.1009997.t003
DOI:
10.1371/journal.pcbi.1009997.s001
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2193340-6
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