In:
Neurourology and Urodynamics, Wiley, Vol. 37, No. 4 ( 2018-04), p. 1272-1280
Abstract:
To investigate the feasibility of restoring bladder function and prevention of renal deterioration by neurorrhaphy in rats with neurogenic bladder (NB). Methods Forty‐two rats were assigned to the end‐to‐side nerve coaptation group (ECG, n = 16), no nerve coaptation group (NCG, n = 16), and control group (CG, n = 10). In the ECG, the left ventral root (VR) and dorsal root (DR) of L6 and S1 were transected, and the distal stump of L6VR was sutured to the lateral face of L4VR. In the NCG, the left VR and DR of L6 and S1 were transected, but coaptation was not performed. In the CG, no operation was performed. Nerve regeneration, bladder function, and renal function were evaluated by FluoroGold (FG) retrograde tract tracing, cystometry, electrical stimulation, MRI, histology and biochemical assays. Results In the ECG, FG‐labeled neurons were observed in the left ventral horn of L4 spinal cord. There was a significant increase in intravesical pressure upon stimulation of the left L4VR proximal to the coaptation. Maximum cystometric capacity, post‐void residual urine, bladder compliance and weight, serum creatinine, blood urea nitrogen, and fibrotic area of bladder and kidney were lower in the ECG than in the NCG, but higher than the CG. Hydronephrosis was noticed in ECG and NCG rats. Maximum detrusor voiding pressure was higher in the ECG and CG than in the NCG. Conclusions End‐to‐side neurorrhaphy is a useful method for restoring bladder function and preventing renal injury in rats with NB.
Type of Medium:
Online Resource
ISSN:
0733-2467
,
1520-6777
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1500793-5
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