In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 4 ( 2023-4-25), p. e0284728-
Abstract:
Early biomarkers are needed to identify patients at risk of developing postoperative cognitive dysfunction (POCD). Our objective was to determine neuronal injury-related biomarkers with predictive values for this condition. Six biomarkers (S100β, neuron-specific enolase [NSE], amyloid beta [Aβ] , tau, neurofilament light chain, and glial fibrillary acidic protein) were evaluated. According to the first postoperative sampling time, observational studies showed that S100β was significantly higher in patients with POCD than in those without POCD (standardized mean difference [SMD]: 6.92, 95% confidence interval [CI] : 4.44−9.41). The randomized controlled trial (RCT) showed that S100β (SMD: 37.31, 95% CI: 30.97−43.64) and NSE (SMD: 3.50, 95% CI: 2.71−4.28) in the POCD group were significantly higher than in the non-POCD group. The pooled data of observational studies by postoperative sampling time showed significantly higher levels of the following biomarkers in the POCD groups than in the control groups: S100β levels at 1 hour (SMD: 1.35, 95% CI: 0.07−2.64), 2 days (SMD: 27.97, 95% CI: 25.01−30.94), and 9 days (SMD: 6.41, 95% CI: 5.64−7.19); NSE levels at 1 hour (SMD: 0.92, 95% CI: 0.25−1.60), 6 hours (SMD: 0.79, 95% CI: 0.12−1.45), and 24 hours (SMD: 0.84, 95% CI: 0.38−1.29); and Aβ levels at 24 hours (SMD: 2.30, 95% CI: 1.54−3.06), 2 days (SMD: 2.30, 95% CI: 1.83−2.78), and 9 days (SMD: 2.76, 95% CI: 2.25−3.26). The pooled data of the RCT showed that the following biomarkers were significantly higher in POCD patients than in non-POCD patients: S100β levels at 2 days (SMD: 37.31, 95% CI: 30.97−43.64) and 9 days (SMD: 126.37, 95% CI: 104.97−147.76) and NSE levels at 2 days (SMD: 3.50, 95% CI: 2.71−4.28) and 9 days (SMD: 8.53, 95% CI: 7.00−10.06). High postoperative levels of S100β, NSE, and Aβ may predict POCD. The relationship between these biomarkers and POCD may be affected by sampling time.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0284728
DOI:
10.1371/journal.pone.0284728.g001
DOI:
10.1371/journal.pone.0284728.g002
DOI:
10.1371/journal.pone.0284728.g003
DOI:
10.1371/journal.pone.0284728.g004
DOI:
10.1371/journal.pone.0284728.g005
DOI:
10.1371/journal.pone.0284728.t001
DOI:
10.1371/journal.pone.0284728.s001
DOI:
10.1371/journal.pone.0284728.s002
DOI:
10.1371/journal.pone.0284728.s003
DOI:
10.1371/journal.pone.0284728.s004
DOI:
10.1371/journal.pone.0284728.s005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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