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  • 1
    Online Resource
    Online Resource
    IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin
    Springer Science and Business Media LLC ; 2021
    In:  Journal of Hematology & Oncology Vol. 14, No. 1 ( 2021-12)
    Details
    In: Journal of Hematology & Oncology, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2021-12)
    Abstract: Although chimeric antigen receptor (CAR)-engineered T cells have shown great success in the treatment of B cell malignancies, this strategy has limited efficacy in patients with solid tumors. In mouse CAR-T cells, IL-7 and CCL19 expression have been demonstrated to improve T cell infiltration and CAR-T cell survival in mouse tumors. Therefore, in the current study, we engineered human CAR-T cells to secrete human IL-7 and CCL19 (7 × 19) and found that these 7 × 19 CAR-T cells showed enhanced capacities of expansion and migration in vitro. Furthermore, 7 × 19 CAR-T cells showed superior tumor suppression ability compared to conventional CAR-T cells in xenografts of hepatocellular carcinoma (HCC) cell lines, primary HCC tissue samples and pancreatic carcinoma (PC) cell lines. We then initiated a phase 1 clinical trial in advanced HCC/PC/ovarian carcinoma (OC) patients with glypican-3 (GPC3) or mesothelin (MSLN) expression. In a patient with advanced HCC, anti-GPC3-7 × 19 CAR-T treatment resulted in complete tumor disappearance 30 days post intratumor injection. In a patient with advanced PC, anti-MSLN-7 × 19 CAR-T treatment resulted in almost complete tumor disappearance 240 days post-intravenous infusion. Our results demonstrated that the incorporation of 7 × 19 into CAR-T cells significantly enhanced the antitumor activity against human solid tumor. Trial registration: NCT03198546. Registered 26 June 2017, https://clinicaltrials.gov/ct2/show/NCT03198546?term=NCT03198546 & draw=2 & rank=1
    Type of Medium: Online Resource
    ISSN: 1756-8722
    URL: Article
    DOI: 10.1186/s13045-021-01128-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2429631-4
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  • 2
    Online Resource
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    Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement
    Elsevier BV ; 2023
    In:  Heliyon Vol. 9, No. 4 ( 2023-04), p. e15418-
    Details
    In: Heliyon, Elsevier BV, Vol. 9, No. 4 ( 2023-04), p. e15418-
    Type of Medium: Online Resource
    ISSN: 2405-8440
    URL: Article
    DOI: 10.1016/j.heliyon.2023.e15418
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2835763-2
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  • 3
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    Selective area epitaxy of PbTe-Pb hybrid nanowires on a lattice-matched substrate
    American Physical Society (APS) ; 2022
    In:  Physical Review Materials Vol. 6, No. 3 ( 2022-3-23)
    Details
    In: Physical Review Materials, American Physical Society (APS), Vol. 6, No. 3 ( 2022-3-23)
    Type of Medium: Online Resource
    ISSN: 2475-9953
    URL: Article
    DOI: 10.1103/PhysRevMaterials.6.034205
    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 2022
    detail.hit.zdb_id: 2898355-5
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  • 4
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    Anti‐Inflammatory and Anti‐Osteoclastogenesis Activities of Different Kinds of Zanthoxylum bungeanum Seed Oil in Vitro
    Wiley ; 2023
    In:  Chemistry & Biodiversity Vol. 20, No. 5 ( 2023-05)
    Details
    In: Chemistry & Biodiversity, Wiley, Vol. 20, No. 5 ( 2023-05)
    Abstract: Our previous study has exhibited that one kind of Zanthoxylum bungeanum seed oil (ZSO), extracted from Zanthoxylum bungeanum seed, had inhibitory effects on osteoclastogenesis. However, the anti‐osteoclastogenesis activities of different kinds of ZSO are scarcely reported. Since inflammation is related to bone loss and osteoporosis, in this study, three kinds of ZSO, Zanthoxylum schinifolium Siebold et Zucc seed oil (ZSSO), Zanthoxylum armatum DC. seed oil (ZDSO) and Zanthoxylum bungeanum maximum seed oil (ZBSO), were obtained with Soxhlet extraction and their fatty acid constituents were detected by GC‐FID. RAW264.7 macrophages induced by lipopolysaccharide (LPS) were used to evaluate the inhibitory effects of three kinds of ZSO on inflammation via detecting the expression levels of inflammatory factors by RT‐qPCR. Moreover, RANKL‐induced osteoclastogenesis was applied to demonstrate the anti‐osteoclastogenesis activities of them through tartrate‐resistant acid phosphatase (TRAP) staining and RT‐qPCR. The GC‐FID results exhibited that the highest constituent in ZSSO and ZDSO was oleic acid (OA) and palmitoleic acid (PLA), respectively. While linoleic acid (LA) and α‐Linolenic acid (ALA) in ZBSO were dominant. At the concentration of 0.5 μL/mL, all three kinds of ZSO could decrease the expression levels of inducible NO synthase (iNOS), cyclooxygenase‐2 (COX‐2), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), interleukin‐1 beta (IL‐1β) in LPS‐induced macrophages. At the concentration of 0.25 μL/mL, only ZSSO could decrease the expression levels of iNOS and COX‐2, which implied the inhibitory effects of ZSSO were stronger than other ZSOs. The number of RANKL‐induced osteoclasts and the expressions of nuclear factor kappa‐B (NF‐κB), TNF‐α and IL‐6 in the cells were decreased after being treated with ZSOs at the concentration of 0.5 μL/mL, while the number of RANKL‐induced osteoclasts after treated with ZBSO were less than those treated with other ZSOs, this indicated that the anti‐osteoclastogenesis effect of ZBSO were stronger than other ZSOs. In conclusion, the fatty acid compositions of three major kinds of ZSO were compared and the content of unsaturated fatty acids especially ω‐3 polyunsaturated fatty acids in ZBSO were the highest among them. All ZSOs tested had anti‐inflammatory and anti‐osteoclastogenesis activities. And their anti‐osteoclastogenesis effects might be related to the suppression of the NF‐κB pathway.
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    URL: Article
    DOI: 10.1002/cbdv.v20.5
    DOI: 10.1002/cbdv.202201157
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2139001-0
    SSG: 12
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  • 5
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    Cytoprotective Effect of Ligustrum robustum Polyphenol Extract against Hydrogen Peroxide-Induced Oxidative Stress via Nrf2 Signaling Pathway in Caco-2 Cells
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-06-13), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-06-13), p. 1-8
    Abstract: Ligustrum robustum is a traditional herbal tea that is widely distributed in southwest China. The health effects of L. robustum are characteristics of clearing heat, antioxidant, inducing resurgence, and improving digestion. However, the molecular mechanisms related to these effects, particularly the antioxidant mechanism, have been seldom reported. The objective of this study was to assess antioxidative capacity of L. robustum , and its protective effects and mechanisms against hydrogen peroxide (H 2 O 2 ) - induced toxicity in Caco-2 cells. Total phenolic contents, free radical scavenging activity, and reducing capacity of L. robustum were measured. The effects of L. robustum on the cell viability and antioxidant defense system were explored. The expression of nuclear factor E2 related factor 2 (Nrf2) and antioxidant genes: quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutamate cysteine ligase (GCL) were analyzed by western blot and qPCR. Pretreatment of L. robustum could significantly reduce H 2 O 2 -induced toxicity, decrease the level of reactive oxygen species (ROS) and malondialdehyde (MDA), and increase the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GR). By activating the expression of Nrf2 and antioxidant genes (NQO1, HO-1, and GCL), L. robustum exerts cytoprotective effect in Caco-2 cells dealt with H 2 O 2 . Therefore, the well-established model of Caco-2 cells demonstrates that L. robustum may modulate the cytoprotective effect against the H 2 O 2 -induced oxidative stress through the Nrf2 signaling pathway.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/5026458
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 6
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    The Wood Slice Cell Image Identification Algorithm Based on Singular Value Decomposition
    American Scientific Publishers ; 2015
    In:  Journal of Computational and Theoretical Nanoscience Vol. 12, No. 12 ( 2015-12-01), p. 5372-5378
    Details
    In: Journal of Computational and Theoretical Nanoscience, American Scientific Publishers, Vol. 12, No. 12 ( 2015-12-01), p. 5372-5378
    Type of Medium: Online Resource
    ISSN: 1546-1955
    URL: Article
    DOI: 10.1166/jctn.2015.4529
    Language: English
    Publisher: American Scientific Publishers
    Publication Date: 2015
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  • 7
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    Corneal nerve structure in patients with primary Sjögren’s syndrome in China
    Springer Science and Business Media LLC ; 2021
    In:  BMC Ophthalmology Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Ophthalmology, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: The aim of this study was to evaluate the in vivo confocal microscopic morphology of corneal subbasal nerves and its relationship with clinical parameters in patients with primary Sjögren’s syndrome in China. Methods This was a case control study of 22 dry eye disease (DED) patients with primary Sjögren’s syndrome (pSS) and 20 control subjects with non-Sjögren dry eye disease (NSDE). Each patient underwent an evaluation of ocular surface disease using the tear film break-up time (TBUT), noninvasive tear film break-up time (NIKBUT), noninvasive tear meniscus height (NIKTMH), corneal staining (National Eye Institute scale, NEI), Schirmer I test, meibography, and corneal subbasal nerve analysis with in vivo confocal microscopy (IVCM). The right eye of each subject was included in this study. Results SS patients showed a shorter TBUT ( P  = 0.009) and Schirmer I test results ( P  = 0.028) than the NSDE group. However, there was no significant difference in NIKBUT between the two groups ( P  = 0.393). The nerve density of subbasal nerves, number of nerves and tortuosity of the SS group were significantly lower than those of the NSDE group ( P  = 0.001, P   〈  0.001 and P  = 0.039, respectively). In the SS group, the mean nerve length was correlated with age and the Schirmer I test (r = − 0.519, P  = 0.013 and r = 0.463, P  = 0.035, respectively). Corneal staining was correlated with nerve density and the number of nerves (r = − 0.534, P = 0.013 and r = − 0.487, P  = 0.025, respectively). Conclusions Sjögren syndrome dry eye (SSDE) patients have more severe clinical dry eye parameters than non-Sjögren dry eye disease (NSDE) patients. Compared with NSDE patients, we found that SSDE patients showed decreased corneal subbasal nerve density and numbers.
    Type of Medium: Online Resource
    ISSN: 1471-2415
    URL: Article
    DOI: 10.1186/s12886-021-01967-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2050436-6
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  • 8
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    Systematic review and meta-analysis of probiotics in the treatment of allergic rhinitis
    Codon Publications ; 2022
    In:  Allergologia et Immunopathologia Vol. 50, No. 3 ( 2022-05-01), p. 24-37
    Details
    In: Allergologia et Immunopathologia, Codon Publications, Vol. 50, No. 3 ( 2022-05-01), p. 24-37
    Abstract: Background: The purpose of this meta-analysis is to systematically evaluate the efficacy of probiotics on allergic rhinitis (AR). Methods: Collecting randomized controlled trials (RCTs) with probiotics as intervention measures for AR, two researchers independently screened the literature, extracted the data and evaluated the methodological quality of the included studies, and used RevMan 5.3 software for meta-analysis to observe the effects of probiotics on Rhinitis Quality of Life (RQLQ) scores, Rhinitis Total Symptom Scores (RTSS), blood eosinophil count, total and antigen-specific serum immunoglobulin E (IgE) levels by using the fixed- or the random-effects model to calculate the pooled risk for significant heterogeneity. Results: A total of 2708 patients were included in 30 RCTs. Meta-analysis results showed that the RQLQ global scores (mean difference [MD] = −9.43; P 〈 0.00001), RQLQ nasal scores (MD = −1.52; P = 0.03), and RTSS nasal scores (MD = −1.96; P = 0.02) significantly improved in the probiotic group when compared with those in the placebo group. There was no significant difference in blood eosinophil count (MD = −0.09; P=0.82), RQLQ eye scores (MD = −1.45; P = 0.07), RTSS global scores (MD = −2.24; P = 0.26), RTSS eye scores (MD = −0.39; P = 0.31), total and antigen-specific serum IgE levels (MD = −0.04; P = 0.7 and MD = −0.08; P = 0.81) between the probiotic and the placebo group. Conclusion: Compared with the placebo group, the quality of life and symptoms of patients with AR significantly improved in the probiotic group, thus providing a new potential method for the application of probiotics in AR. However, because of the limited evidence for the current study outcomes, the heterogeneity of research, and the differences in research results, more high-quality studies are needed to in the future.
    Type of Medium: Online Resource
    ISSN: 0301-0546
    URL: Article
    DOI: 10.15586/aei.v50i3.507
    Language: Unknown
    Publisher: Codon Publications
    Publication Date: 2022
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  • 9
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    Individualized causal discovery with latent trajectory embedded Bayesian networks
    Wiley ; 2023
    In:  Biometrics
    Details
    In: Biometrics, Wiley
    Abstract: Bayesian networks have been widely used to generate causal hypotheses from multivariate data. Despite their popularity, the vast majority of existing causal discovery approaches make the strong assumption of a (partially) homogeneous sampling scheme. However, such assumption can be seriously violated, causing significant biases when the underlying population is inherently heterogeneous. To this end, we propose a novel causal Bayesian network model, termed BN‐LTE, that embeds heterogeneous samples onto a low‐dimensional manifold and builds Bayesian networks conditional on the embedding. This new framework allows for more precise network inference by improving the estimation resolution from the population level to the observation level. Moreover, while causal Bayesian networks are in general not identifiable with purely observational, cross‐sectional data due to Markov equivalence, with the blessing of causal effect heterogeneity, we prove that the proposed BN‐LTE is uniquely identifiable under relatively mild assumptions. Through extensive experiments, we demonstrate the superior performance of BN‐LTE in causal structure learning as well as inferring observation‐specific gene regulatory networks from observational data.
    Type of Medium: Online Resource
    ISSN: 0006-341X , 1541-0420
    URL: Article
    DOI: 10.1111/biom.13843
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2054197-1
    SSG: 12
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  • 10
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    Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action
    Frontiers Media SA ; 2023
    In:  Frontiers in Pharmacology Vol. 14 ( 2023-8-24)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 14 ( 2023-8-24)
    Abstract: Colorectal cancer (CRC) is the third most common malignant tumor in the world, and it is prone to recurrence and metastasis during treatment. Aerobic glycolysis is one of the main characteristics of tumor cell metabolism in CRC. Tumor cells rely on glycolysis to rapidly consume glucose and to obtain more lactate and intermediate macromolecular products so as to maintain growth and proliferation. The regulation of the CRC glycolysis pathway is closely associated with several signal transduction pathways and transcription factors including phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), hypoxia-inducible factor-1 (HIF-1), myc, and p53. Targeting the glycolytic pathway has become one of the key research aspects in CRC therapy. Many phytochemicals were shown to exert anti-CRC activity by targeting the glycolytic pathway. Here, we review the effects and mechanisms of phytochemicals on CRC glycolytic pathways, providing a new method of drug development.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2023.1257450
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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