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  • 1
    Online-Ressource
    Online-Ressource
    IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin
    Springer Science and Business Media LLC ; 2021
    In:  Journal of Hematology & Oncology Vol. 14, No. 1 ( 2021-12)
    Details
    In: Journal of Hematology & Oncology, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2021-12)
    Kurzfassung: Although chimeric antigen receptor (CAR)-engineered T cells have shown great success in the treatment of B cell malignancies, this strategy has limited efficacy in patients with solid tumors. In mouse CAR-T cells, IL-7 and CCL19 expression have been demonstrated to improve T cell infiltration and CAR-T cell survival in mouse tumors. Therefore, in the current study, we engineered human CAR-T cells to secrete human IL-7 and CCL19 (7 × 19) and found that these 7 × 19 CAR-T cells showed enhanced capacities of expansion and migration in vitro. Furthermore, 7 × 19 CAR-T cells showed superior tumor suppression ability compared to conventional CAR-T cells in xenografts of hepatocellular carcinoma (HCC) cell lines, primary HCC tissue samples and pancreatic carcinoma (PC) cell lines. We then initiated a phase 1 clinical trial in advanced HCC/PC/ovarian carcinoma (OC) patients with glypican-3 (GPC3) or mesothelin (MSLN) expression. In a patient with advanced HCC, anti-GPC3-7 × 19 CAR-T treatment resulted in complete tumor disappearance 30 days post intratumor injection. In a patient with advanced PC, anti-MSLN-7 × 19 CAR-T treatment resulted in almost complete tumor disappearance 240 days post-intravenous infusion. Our results demonstrated that the incorporation of 7 × 19 into CAR-T cells significantly enhanced the antitumor activity against human solid tumor. Trial registration: NCT03198546. Registered 26 June 2017, https://clinicaltrials.gov/ct2/show/NCT03198546?term=NCT03198546 & draw=2 & rank=1
    Materialart: Online-Ressource
    ISSN: 1756-8722
    URL: Article
    DOI: 10.1186/s13045-021-01128-9
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2021
    ZDB Id: 2429631-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Corneal nerve structure in patients with primary Sjögren’s syndrome in China
    Springer Science and Business Media LLC ; 2021
    In:  BMC Ophthalmology Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Ophthalmology, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Kurzfassung: The aim of this study was to evaluate the in vivo confocal microscopic morphology of corneal subbasal nerves and its relationship with clinical parameters in patients with primary Sjögren’s syndrome in China. Methods This was a case control study of 22 dry eye disease (DED) patients with primary Sjögren’s syndrome (pSS) and 20 control subjects with non-Sjögren dry eye disease (NSDE). Each patient underwent an evaluation of ocular surface disease using the tear film break-up time (TBUT), noninvasive tear film break-up time (NIKBUT), noninvasive tear meniscus height (NIKTMH), corneal staining (National Eye Institute scale, NEI), Schirmer I test, meibography, and corneal subbasal nerve analysis with in vivo confocal microscopy (IVCM). The right eye of each subject was included in this study. Results SS patients showed a shorter TBUT ( P  = 0.009) and Schirmer I test results ( P  = 0.028) than the NSDE group. However, there was no significant difference in NIKBUT between the two groups ( P  = 0.393). The nerve density of subbasal nerves, number of nerves and tortuosity of the SS group were significantly lower than those of the NSDE group ( P  = 0.001, P   〈  0.001 and P  = 0.039, respectively). In the SS group, the mean nerve length was correlated with age and the Schirmer I test (r = − 0.519, P  = 0.013 and r = 0.463, P  = 0.035, respectively). Corneal staining was correlated with nerve density and the number of nerves (r = − 0.534, P = 0.013 and r = − 0.487, P  = 0.025, respectively). Conclusions Sjögren syndrome dry eye (SSDE) patients have more severe clinical dry eye parameters than non-Sjögren dry eye disease (NSDE) patients. Compared with NSDE patients, we found that SSDE patients showed decreased corneal subbasal nerve density and numbers.
    Materialart: Online-Ressource
    ISSN: 1471-2415
    URL: Article
    DOI: 10.1186/s12886-021-01967-7
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2021
    ZDB Id: 2050436-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Gut microbiome alteration as a diagnostic tool and associated with inflammatory response marker in primary liver cancer
    Springer Science and Business Media LLC ; 2022
    In:  Hepatology International Vol. 16, No. 1 ( 2022-02), p. 99-111
    Details
    In: Hepatology International, Springer Science and Business Media LLC, Vol. 16, No. 1 ( 2022-02), p. 99-111
    Materialart: Online-Ressource
    ISSN: 1936-0533 , 1936-0541
    URL: Article
    DOI: 10.1007/s12072-021-10279-3
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 2270316-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Tunable terahertz Dirac-semimetal hybrid plasmonic waveguides
    Optica Publishing Group ; 2022
    In:  Optical Materials Express Vol. 12, No. 1 ( 2022-01-01), p. 73-
    Details
    In: Optical Materials Express, Optica Publishing Group, Vol. 12, No. 1 ( 2022-01-01), p. 73-
    Kurzfassung: Based on the Dirac semimetals (DSM) modified hybrid plasmonic waveguides, the tunable propagation properties have been systematical investigated by using the finite element method in the THz region, including the influences of structural parameters, the shape of dielectric fiber and Fermi levels of DSM layers. The results show that as the operation frequency increases, the real part of propagation constant increases, and the loss shows a peak. The shape of dielectric fiber (the elliptical structural parameter δ) affects the propagation property obviously, as the structural parameter decreases, the confinement and figure of merit increase, the loss reduces. With the increase of Fermi level of DSM layer, the imaginary part of propagation constant decreases, the modulation depth of loss is more than 95% if the Fermi level changes in the range of 0.01-0.15 eV. In addition, as the permittivity of dielectric material filling in the slit increases, the mode confinement and loss increases, FOM decreases. The results are very helpful to understand the tunable mechanisms of hybrid waveguides and design novel plasmonic devices in the future, e.g. modulators, filters, lasers and resonators.
    Materialart: Online-Ressource
    ISSN: 2159-3930
    URL: Article
    DOI: 10.1364/OME.445362
    Sprache: Englisch
    Verlag: Optica Publishing Group
    Publikationsdatum: 2022
    ZDB Id: 2619914-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Cytoprotective Effect of Ligustrum robustum Polyphenol Extract against Hydrogen Peroxide-Induced Oxidative Stress via Nrf2 Signaling Pathway in Caco-2 Cells
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-06-13), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-06-13), p. 1-8
    Kurzfassung: Ligustrum robustum is a traditional herbal tea that is widely distributed in southwest China. The health effects of L. robustum are characteristics of clearing heat, antioxidant, inducing resurgence, and improving digestion. However, the molecular mechanisms related to these effects, particularly the antioxidant mechanism, have been seldom reported. The objective of this study was to assess antioxidative capacity of L. robustum , and its protective effects and mechanisms against hydrogen peroxide (H 2 O 2 ) - induced toxicity in Caco-2 cells. Total phenolic contents, free radical scavenging activity, and reducing capacity of L. robustum were measured. The effects of L. robustum on the cell viability and antioxidant defense system were explored. The expression of nuclear factor E2 related factor 2 (Nrf2) and antioxidant genes: quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutamate cysteine ligase (GCL) were analyzed by western blot and qPCR. Pretreatment of L. robustum could significantly reduce H 2 O 2 -induced toxicity, decrease the level of reactive oxygen species (ROS) and malondialdehyde (MDA), and increase the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GR). By activating the expression of Nrf2 and antioxidant genes (NQO1, HO-1, and GCL), L. robustum exerts cytoprotective effect in Caco-2 cells dealt with H 2 O 2 . Therefore, the well-established model of Caco-2 cells demonstrates that L. robustum may modulate the cytoprotective effect against the H 2 O 2 -induced oxidative stress through the Nrf2 signaling pathway.
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/5026458
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    α-Linolenic Acid Inhibits RANKL-Induced Osteoclastogenesis In Vitro and Prevents Inflammation In Vivo
    MDPI AG ; 2023
    In:  Foods Vol. 12, No. 3 ( 2023-02-03), p. 682-
    Details
    In: Foods, MDPI AG, Vol. 12, No. 3 ( 2023-02-03), p. 682-
    Kurzfassung: Inflammation is an important risk factor for bone-destroying diseases. Our preliminary research found that Zanthoxylum bungeanum seed oil (ZBSO) is abundant in unsaturated fatty acids and could inhibit osteoclastogenesis in receptor activator of nuclear factor κB ligand (RANKL)-induced RAW264.7 cells. However, the key constituents in ZBSO in the prevention of osteoclastogenesis and its possible mechanism related to inflammation are still unclear. Therefore, in this study, oleic acid (OA), linoleic acid (LA), palmitoleic acid (PLA), and alpha-linolenic acid (ALA) in ZBSO, havingthe strongest effect on RANKL-induced osteoclastogenesis, were selected by a tartrate-resistant acid phosphatase (TRAP) staining method. Furthermore, the effects of the selected fatty acids on anti-inflammation and anti-osteoclastogenesis in vitro and in vivo were assessed using RT-qPCR. Among the four major unsaturated fatty acids we tested, ALA displayed the strongest inhibitory effect on osteoclastogenesis. The increased expression of free fatty acid receptor 4 (FFAR4) and β-arrestin2 (βarr2), as well as the decreased expression of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), nuclear factor of activated T-cells c1 (NFATc1), and tartrate-resistant acid phosphatase (TRAP) in RAW264.7 cells after ALA treatment were observed. Moreover, in ovariectomized osteoporotic rats with ALA preventive intervention, we found that the expression of TNF-α, interleukin-6 (IL-6), interleukin-1β (IL-1β), NFATc1, and TRAP were decreased, while with the ALA therapeutic intervention, downregulated expression of NF-κB, NFATc1, TRAP, and transforming growth factor beta-activated kinase 1 (TAK1) were noticed. These results indicate that ALA, as the major unsaturated fatty acid in ZBSO, could inhibit RANKL-induced osteoclastogenesis via the FFAR4/βarr2 signaling pathway and could prevent inflammation, suggesting that ZBSO may be a promising potential natural product of unsaturated fatty acids and a dietary supplement for the prevention of osteoclastogenesis and inflammatory diseases.
    Materialart: Online-Ressource
    ISSN: 2304-8158
    URL: Article
    DOI: 10.3390/foods12030682
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2704223-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Multi‐technical analysis on the antioxidative capacity and total phenol contents of 94 traditional Chinese dietary medicinal herbs
    Wiley ; 2018
    In:  Food Science & Nutrition Vol. 6, No. 6 ( 2018-09), p. 1358-1369
    Details
    In: Food Science & Nutrition, Wiley, Vol. 6, No. 6 ( 2018-09), p. 1358-1369
    Kurzfassung: Dietary medicinal herbs ( DMH s) are superior reservoirs for natural antioxidants and safe for long‐term consumption. Chinese government recently announced an official list of traditional Chinese DMH s to support civil health promotion. However, antioxidative capacity ( AOC ) and total phenol contents ( TPC ) of these listed herbs were not comprehensively and systematically evaluated. In this study, AOC of 94 listed DMH s in water extract were investigated by three techniques including radical scavenging and ferric reducing antioxidative power. The results showed that emblic leafflower, rose, and clove possessed the highest AOC , while TPC was significantly correlated with AOC . While traditional Chinese medicines are categorized by the nature of Yin‐Yang, this study demonstrated that Yin DMH s are statistically correlated with high AOC . Practical application: In this study, AOC and TPC of 94 traditional Chinese DMHs were documented systematically. Emblic leafflower, rose and clove were shown to possess the highest AOC. TPC in traditional Chinese DMHs was significantly correlated with the AOC, while DMHs with Yin characteristic might be used as an indicator to identify potential antioxidative herbs.
    Materialart: Online-Ressource
    ISSN: 2048-7177 , 2048-7177
    URL: Issue
    URL: Article
    DOI: 10.1002/fsn3.2018.6.issue-6
    DOI: 10.1002/fsn3.689
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 2703010-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    The Wood Slice Cell Image Identification Algorithm Based on Singular Value Decomposition
    American Scientific Publishers ; 2015
    In:  Journal of Computational and Theoretical Nanoscience Vol. 12, No. 12 ( 2015-12-01), p. 5372-5378
    Details
    In: Journal of Computational and Theoretical Nanoscience, American Scientific Publishers, Vol. 12, No. 12 ( 2015-12-01), p. 5372-5378
    Materialart: Online-Ressource
    ISSN: 1546-1955
    URL: Article
    DOI: 10.1166/jctn.2015.4529
    Sprache: Englisch
    Verlag: American Scientific Publishers
    Publikationsdatum: 2015
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Bayesian biclustering for microbial metagenomic sequencing data via multinomial matrix factorization
    Oxford University Press (OUP) ; 2022
    In:  Biostatistics Vol. 23, No. 3 ( 2022-07-18), p. 891-909
    Details
    In: Biostatistics, Oxford University Press (OUP), Vol. 23, No. 3 ( 2022-07-18), p. 891-909
    Kurzfassung: High-throughput sequencing technology provides unprecedented opportunities to quantitatively explore human gut microbiome and its relation to diseases. Microbiome data are compositional, sparse, noisy, and heterogeneous, which pose serious challenges for statistical modeling. We propose an identifiable Bayesian multinomial matrix factorization model to infer overlapping clusters on both microbes and hosts. The proposed method represents the observed over-dispersed zero-inflated count matrix as Dirichlet-multinomial mixtures on which latent cluster structures are built hierarchically. Under the Bayesian framework, the number of clusters is automatically determined and available information from a taxonomic rank tree of microbes is naturally incorporated, which greatly improves the interpretability of our findings. We demonstrate the utility of the proposed approach by comparing to alternative methods in simulations. An application to a human gut microbiome data set involving patients with inflammatory bowel disease reveals interesting clusters, which contain bacteria families Bacteroidaceae, Bifidobacteriaceae, Enterobacteriaceae, Fusobacteriaceae, Lachnospiraceae, Ruminococcaceae, Pasteurellaceae, and Porphyromonadaceae that are known to be related to the inflammatory bowel disease and its subtypes according to biological literature. Our findings can help generate potential hypotheses for future investigation of the heterogeneity of the human gut microbiome.
    Materialart: Online-Ressource
    ISSN: 1465-4644 , 1468-4357
    URL: Article
    DOI: 10.1093/biostatistics/kxab002
    Sprache: Englisch
    Verlag: Oxford University Press (OUP)
    Publikationsdatum: 2022
    ZDB Id: 2020601-X
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Anti‐Inflammatory and Anti‐Osteoclastogenesis Activities of Different Kinds of Zanthoxylum bungeanum Seed Oil in Vitro
    Wiley ; 2023
    In:  Chemistry & Biodiversity Vol. 20, No. 5 ( 2023-05)
    Details
    In: Chemistry & Biodiversity, Wiley, Vol. 20, No. 5 ( 2023-05)
    Kurzfassung: Our previous study has exhibited that one kind of Zanthoxylum bungeanum seed oil (ZSO), extracted from Zanthoxylum bungeanum seed, had inhibitory effects on osteoclastogenesis. However, the anti‐osteoclastogenesis activities of different kinds of ZSO are scarcely reported. Since inflammation is related to bone loss and osteoporosis, in this study, three kinds of ZSO, Zanthoxylum schinifolium Siebold et Zucc seed oil (ZSSO), Zanthoxylum armatum DC. seed oil (ZDSO) and Zanthoxylum bungeanum maximum seed oil (ZBSO), were obtained with Soxhlet extraction and their fatty acid constituents were detected by GC‐FID. RAW264.7 macrophages induced by lipopolysaccharide (LPS) were used to evaluate the inhibitory effects of three kinds of ZSO on inflammation via detecting the expression levels of inflammatory factors by RT‐qPCR. Moreover, RANKL‐induced osteoclastogenesis was applied to demonstrate the anti‐osteoclastogenesis activities of them through tartrate‐resistant acid phosphatase (TRAP) staining and RT‐qPCR. The GC‐FID results exhibited that the highest constituent in ZSSO and ZDSO was oleic acid (OA) and palmitoleic acid (PLA), respectively. While linoleic acid (LA) and α‐Linolenic acid (ALA) in ZBSO were dominant. At the concentration of 0.5 μL/mL, all three kinds of ZSO could decrease the expression levels of inducible NO synthase (iNOS), cyclooxygenase‐2 (COX‐2), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), interleukin‐1 beta (IL‐1β) in LPS‐induced macrophages. At the concentration of 0.25 μL/mL, only ZSSO could decrease the expression levels of iNOS and COX‐2, which implied the inhibitory effects of ZSSO were stronger than other ZSOs. The number of RANKL‐induced osteoclasts and the expressions of nuclear factor kappa‐B (NF‐κB), TNF‐α and IL‐6 in the cells were decreased after being treated with ZSOs at the concentration of 0.5 μL/mL, while the number of RANKL‐induced osteoclasts after treated with ZBSO were less than those treated with other ZSOs, this indicated that the anti‐osteoclastogenesis effect of ZBSO were stronger than other ZSOs. In conclusion, the fatty acid compositions of three major kinds of ZSO were compared and the content of unsaturated fatty acids especially ω‐3 polyunsaturated fatty acids in ZBSO were the highest among them. All ZSOs tested had anti‐inflammatory and anti‐osteoclastogenesis activities. And their anti‐osteoclastogenesis effects might be related to the suppression of the NF‐κB pathway.
    Materialart: Online-Ressource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    URL: Article
    DOI: 10.1002/cbdv.v20.5
    DOI: 10.1002/cbdv.202201157
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2139001-0
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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