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  • 1
    Online Resource
    Online Resource
    Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress
    Springer Science and Business Media LLC ; 2016
    In:  Journal of Animal Science and Biotechnology Vol. 7, No. 1 ( 2016-12)
    Details
    In: Journal of Animal Science and Biotechnology, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2016-12)
    Type of Medium: Online Resource
    ISSN: 2049-1891
    URL: Article
    DOI: 10.1186/s40104-016-0093-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2630162-3
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  • 2
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    Identification of the Prognostic Value Among Suppressor Of Cytokine Signaling Family Members in Kidney Renal Clear Cell Carcinoma
    Frontiers Media SA ; 2021
    In:  Frontiers in Molecular Biosciences Vol. 8 ( 2021-12-2)
    Details
    In: Frontiers in Molecular Biosciences, Frontiers Media SA, Vol. 8 ( 2021-12-2)
    Abstract: Background: Kidney renal clear cell carcinoma (KIRC) has become one of the most prevalent malignancies worldwide and remains a crucial cause of cancer-related morbidity and mortality. Aberrant activation of the JAK/STAT pathway acts as an important role in KIRC. The suppressor of cytokine signaling (SOCS) family members are the key negative regulators of the JAK/STAT pathway. SOCS family members have been verified to act as significant roles in regulating cellular responses to many cytokines and growth factors. However, whether the expression levels of SOCS affect the prognosis of patients with KIRC is still elusive. Methods: We first evaluated the expression of SOCS family genes in KIRC and determined the correlation between SOCS expression and different clinicopathological features. Then, we analyzed the genetic alterations, potential functions, transcription factor targets, and immune infiltration of SOCS family members based on the information available on public databases. Finally, we assessed the prognostic value of differentially expressed SOCS family members. Results: The expression levels of SOCS2 , SOCS4 , SOCS6 , SOCS7 , and CISH were downregulated in KIRC, and all SOCS genes were associated with clinicopathological features of patients with KIRC. SOCS family members have been predominantly related to protein binding, signaling adaptor activity, and JAK/STAT cascade. We found that STAT3, STAT6, and IRF1 are the key transcription factors that may be participated in the regulation of SOCS. We also found an association between the expression levels of SOCS and the immune infiltrates of KIRC. Finally, we have illuminated that SOCS1 and SOCS3 are risky genes, whereas SOCS2 , SOCS4 , SOCS6 , SOCS7 , and CISH are some of the protective genes for patients with KIRC; based on these, we have created a KIRC prognostic index for predicting the prognosis of patients of KIRC. Conclusion: Our study may contribute to further understanding the functions of SOCS genes in KIRC, which may help clinicians in selecting the appropriate drugs and predicting the outcomes for patients with KIRC.
    Type of Medium: Online Resource
    ISSN: 2296-889X
    URL: Article
    DOI: 10.3389/fmolb.2021.585000
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2814330-9
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  • 3
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    The 100 most-cited articles in urological surgery: A bibliometric analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  International Journal of Surgery Vol. 75 ( 2020-03), p. 74-79
    Details
    In: International Journal of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 75 ( 2020-03), p. 74-79
    Type of Medium: Online Resource
    ISSN: 1743-9191
    URL: Article
    DOI: 10.1016/j.ijsu.2019.12.030
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2201966-2
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  • 4
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    The application study of dual-energy CT nonlinear blending technique in pulmonary angiography*
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Oncology and Translational Medicine Vol. 9, No. 1 ( 2023-02), p. 22-27
    Details
    In: Oncology and Translational Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 9, No. 1 ( 2023-02), p. 22-27
    Abstract: This study aimed to explore the feasibility of enhancing image quality in computed tomography (CT) pulmonary angiography (CTPA) and reducing radiation dose using the nonlinear blending (NLB) technique of dual-energy CT. Methods A total of 61 patients scheduled for CTPA were enrolled, and 30 patients underwent dual-energy scanning. Nonlinear blending images (NLB group) and three groups of linear blending images (LB group, 80 kV group, and 140 kV group) were reconstructed after scanning; 31 patients underwent single-energy scanning (120 kV group). The CT values and standard deviations of the pulmonary trunk, left and right pulmonary arteries, and ipsilateral back muscle at the bifurcation level of the left and right pulmonary arteries were measured. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the five groups were calculated. The subjective image quality of the five groups was assessed. The radiation doses of the dual- and single-energy groups were recorded and calculated. Results The CNR and SNR values of blood vessels in the NLB group were significantly higher than those in the LB, 140 kV, and 80 kV groups (CNR of pulmonary artery trunk: t = 3.50, 4.06, 7.17, all P 〈 0.05; SNR of pulmonary trunk: t = 3.76, 4.71, 6.92, all P 〈 0.05). There were no statistical differences in the CNR and SNR values between the NLB group and 120 kV group ( P 〉 0.05). The effective radiation dose of the dualenergy group was lower than that of the single-energy group ( t = -4.52, P 〈 0.05). The subjective scores of images in the NLB group were the highest (4.28 ± 0.74). Conclusion The NLB technique of dual-energy CT can improve the image quality of CTPA and reduce the radiation dose, providing more reliable imaging data for the clinical diagnosis of pulmonary embolism.
    Type of Medium: Online Resource
    ISSN: 2095-9621
    URL: Article
    DOI: 10.1007/s10330-021-0544-4
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
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  • 5
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    The impact of implicit theories on resilience among Chinese nurses: The chain mediating effect of grit and meaning in life
    Frontiers Media SA ; 2022
    In:  Frontiers in Psychology Vol. 13 ( 2022-7-28)
    Details
    In: Frontiers in Psychology, Frontiers Media SA, Vol. 13 ( 2022-7-28)
    Abstract: Implicit theories refer to assumptions people hold about different domains, also known as mindsets. There are two implicit theories on the malleability of one’s ability: entity theory and incremental theory. They constrain and regulate people’s understanding and responses to an individual’s behavior, leading to different social cognitive patterns and behavioral responses. Resilience is a positive adaptation in highly stressful situations that represents mechanisms for coping with and transcending difficult experiences, i.e., a person’s ability to successfully adapt to change, resist the adverse effects of stressors, avoid significant dysfunction, and be chronically affected by considered a protective factor for mental health. Although previous studies showed that individuals’ implicit theories are associated with resilience, this relationship has received little attention in the nursing population. It is unclear which variables may contribute to explaining the relationship between implicit theories and resilience. Therefore, the current study aims to deeply explore the relationship between implicit theories and the resilience of Chinese nurses. In addition, we also seek to demonstrate the chain mediating effects of grit and meaning in life on this relationship. We surveyed 709 Chinese nurses through online questionnaires using the self-made demographic questionnaire, the Implicit Theories Scale, the Short Grit Scale, the Meaning in Life Questionnaire, and the 10-item Connor-Davidson Resilience Scale. After controlling for demographic variables such as age, gender, educational background, marital status, professional title, and working years, the results reveal positive associations between Chinese nurses’ implicit theories and their resilience, and grit and meaning in life play a partial mediating role in this relationship, respectively. Furthermore, grit and meaning in life play a chain mediating role between implicit theories and resilience. These findings contribute to understanding the psychological impact mechanism of implicit theories on nurses’ resilience and provide a theoretical basis for nursing managers to formulate strategies to improve nurses’ psychological resilience.
    Type of Medium: Online Resource
    ISSN: 1664-1078
    URL: Article
    DOI: 10.3389/fpsyg.2022.940138
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2563826-9
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  • 6
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    FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells
    Springer Science and Business Media LLC ; 2023
    In:  Cell Death & Disease Vol. 14, No. 4 ( 2023-04-05)
    Details
    In: Cell Death & Disease, Springer Science and Business Media LLC, Vol. 14, No. 4 ( 2023-04-05)
    Abstract: Female subfertility is an increasing reproductive issue worldwide, which is partially related to abnormal ovarian follicular development. Granulosa cells (GCs), by providing the necessary physical support and microenvironment for follicular development, play critical roles in maintaining female fertility. We previously showed that ectopic expression of four and a half LIM domains 2 (FHL2) promoted ovarian granulosa cell tumor progression. However, its function in follicular development and fertility remains unknown. Here, we confirmed that FHL2 is highly expressed in human and mouse ovaries. FHL2 immunosignals were predominantly expressed in ovarian GCs. A Fhl2 knockout (KO) mouse model was generated to examine its roles in follicular development and fertility. Compared with wildtype, knockout of Fhl2 significantly decreased female litter size and offspring number. Furthermore, Fhl2 deficiency reduced ovarian size and impaired follicular development. RNA-sequencing analysis of GCs isolated from either KO or WT mice revealed that, Fhl2 deletion impaired multiple biological functions and signaling pathways, such as Ovarian Putative Early Atresia Granulosa Cell , ErbB , Hippo/YAP , etc. In vitro studies confirmed that FHL2 silencing suppressed GCs growth and EGF-induced GCs proliferation, while its overexpression promoted GC proliferation and decreased apoptosis. Mechanistic studies indicated that FHL2, via forming complexes with transcriptional factors AP-1 or NF-κB, regulated Egf and Egfr expression, respectively. Besides, FHL2 depletion decreased YAP1 expression, especially the active form of YAP1 (nuclear YAP1) in GCs of growing follicles. EGF, serving as an autocrine/paracrine factor, not only induced FHL2 expression and nuclear accumulation, but also stimulated YAP1 expression and activation. Collectively, our study suggests that FHL2 interacts with EGFR and Hippo/YAP signaling to regulate follicular development and maintain fertility. This study illuminates a novel mechanism for follicular development and a potential therapeutic target to address subfertility.
    Type of Medium: Online Resource
    ISSN: 2041-4889
    URL: Article
    DOI: 10.1038/s41419-023-05759-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2541626-1
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  • 7
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    〈p〉The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer〈/p〉
    Informa UK Limited ; 2020
    In:  Cancer Management and Research Vol. Volume 12 ( 2020-05), p. 3673-3689
    Details
    In: Cancer Management and Research, Informa UK Limited, Vol. Volume 12 ( 2020-05), p. 3673-3689
    Type of Medium: Online Resource
    ISSN: 1179-1322
    URL: Article
    DOI: 10.2147/CMAR.S245233
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2508013-1
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  • 8
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    An AANAT / ASMT transgenic animal model constructed with CRISPR /Cas9 system serving as the mammary gland bioreactor to produce melatonin‐enriched milk in sheep
    Wiley ; 2017
    In:  Journal of Pineal Research Vol. 63, No. 1 ( 2017-08)
    Details
    In: Journal of Pineal Research, Wiley, Vol. 63, No. 1 ( 2017-08)
    Abstract: Melatonin as a potent antioxidant exhibits important nutritional and medicinal values. To produce melatonin‐enriched milk will benefit the consumers. In this study, a sheep bioreactor which generates melatonin‐enriched milk has been successfully developed by the technology that combined CRISPR /Cas9 system and microinjection. The AANAT and ASMT were cloned from pineal gland of Dorper sheep ( Ovis aries ). The in vitro studies found that AANAT and ASMT were successfully transferred to the mammary epithelial cell lines and significantly increased melatonin production in the culture medium compared to the nontransgenic cell lines. In addition, the Cas9 mRNA , sg RNA , and the linearized vectors pBC 1‐ AANAT and pBC 1‐ ASMT were co‐injected into the cytoplasm of pronuclear embryos which were implanted into ewes by oviducts transferring. Thirty‐four transgenic sheep were generated with the transgenic positive rate being roughly 35% which were identified by Southern blot and sequencing. Seven carried transgenic AANAT , two carried ASMT , and 25 carried both of AANAT and ASMT genes. RT ‐ PCR and Western blot demonstrated that the lambs expressed these genes in their mammary epithelial cells and these animals produced melatonin‐enriched milk. This is the first report to show a functional AANAT and ASMT transgenic animal model which produce significantly high levels of melatonin milk compared to their wild‐type counterparts. The advanced technologies used in the study laid a foundation for generating large transgenic livestock, for example, the cows, which can produce high level of melatonin milk.
    Type of Medium: Online Resource
    ISSN: 0742-3098 , 1600-079X
    URL: Issue
    URL: Article
    DOI: 10.1111/jpi.2017.63.issue-1
    DOI: 10.1111/jpi.12406
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2027992-9
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  • 9
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    Mammography combined with breast dynamic contrast-enhanced-magnetic resonance imaging for the diagnosis of early breast cancer
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Oncology and Translational Medicine Vol. 2, No. 4 ( 2016-08), p. 165-168
    Details
    In: Oncology and Translational Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 2, No. 4 ( 2016-08), p. 165-168
    Abstract: The aim of this study was to investigate the application of mammography combined with breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the diagnosis of early breast cancer. Methods Mammography and DCE-MRI were performed for 120 patients with breast cancer (malignant, 102; benign; 18). Results The sensitivity of mammography for early diagnosis of breast cancer was 66.67%, specificity was 77.78%, and accuracy was 68.33%. The sensitivity of MRI for early diagnosis of breast cancer was 94.12%, specificity was 88.89%, and accuracy was 93.33%. However, the sensitivity of mammography combined with DCE-MRI volume imaging with enhanced water signal (VIEWS) scanning for early diagnosis of breast cancer was 97.06%, specificity was 94.44%, and accuracy was 96.67%. Conclusion Mammography combined with DCE-MRI increased the sensitivity, specificity, and accuracy of diagnosing early breast cancer.
    Type of Medium: Online Resource
    ISSN: 2095-9621
    URL: Article
    DOI: 10.1007/s10330-016-0155-7
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
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  • 10
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    α‐ketoglutarate delays age‐related fertility decline in mammals
    Wiley ; 2021
    In:  Aging Cell Vol. 20, No. 2 ( 2021-02)
    Details
    In: Aging Cell, Wiley, Vol. 20, No. 2 ( 2021-02)
    Abstract: The fecundity reduction with aging is referred as the reproductive aging which comes earlier than that of chronological aging. Since humans have postponed their childbearing age, to prolong the reproductive age becomes urgent agenda for reproductive biologists. In the current study, we examined the potential associations of α‐ketoglutarate (α‐KG) and reproductive aging in mammals including mice, swine, and humans. There is a clear tendency of reduced α‐KG level with aging in the follicle fluids of human. To explore the mechanisms, mice were selected as the convenient animal model. It is observed that a long term of α‐KG administration preserves the ovarian function, the quality and quantity of oocytes as well as the telomere maintaining system in mice. α‐KG suppresses ATP synthase and alterations of the energy metabolism trigger the nutritional sensors to down‐regulate mTOR pathway. These events not only benefit the general aging process but also maintain ovarian function and delay the reproductive decline. Considering the safety of the α‐KG as a naturally occurring molecule in energy metabolism, its utility in reproduction of large mammals including humans deserves further investigation.
    Type of Medium: Online Resource
    ISSN: 1474-9718 , 1474-9726
    URL: Issue
    URL: Article
    DOI: 10.1111/acel.v20.2
    DOI: 10.1111/acel.13291
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2099130-7
    SSG: 12
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