In:
Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 28, No. 25 ( 2021-08-16), p. 5191-5200
Abstract:
This study aims to conduct a systematic review and meta-analysis
for prospective studies to investigate the improvement effects of natto on bone minera l density
(BMD) in perimenopausal women. Methods: PubMed, EMBASE and Cochrane database searched upto February 2019. This study
was carried out according to the PRISMA guidelines10 for systematic reviews. The protocol of the review was registered in the PROSPERO registry (CRD42019133183). Results: The review identified 3 unique prospective studies comprising 1658 non-overlapping participants.
Meta-analysis showed that natto could significantly improve lumbar bone mineral density (BMD) (P=0.002, WMD=0.26; 95% CI:0.09-0.43) in cohort studies. However, the randomized
controlled study showed no statistical difference between the two (P=0.31, WMD=0.05; 95% CI:- 0.05-0.15). In addition, natto significantly improved the BMD of the femoral neck in a cohort
study and randomized control study (P=0.03, WMD=0.42). 95% CI:0.05-0.79, I2= 72%); (P 〈 0.0001, WMD=0.16; 95% CI:0.08-0.24), respectively. However, all studies demonstrated that
natto has no improvement effects on a hip joint (BMD). In that, the cohort study showed no statistical significance between the natto intake group and the control group (P=0.21, WMD=0.10). 95%
CI:-0.06-0.25, I2= 18%) and the randomized controlled study also showed no statistical significance between the natto intake group and the control group (P=0.09, WMD=-0.06). 95% CI:-0.13-
0.01). Conclusion: Through our current systematic review and meta-analyize of these prosepctive studies
of natto's anti-osteoporostic effecs on BMD, we found that the dietary intake of natto demonstrated a improving effects on the BMD of the femoral neck, but has no effects on the hip joint. Such interesting
results may be related to the differences between anatomical structure between various tissues. Besides that, the results of the RCT study and cohort study on the lumbar spine were not
the same, which may be related to the fact that participants in the RCT study were Caucasian and participants in the cohort study were Asian. Therefore, more large-sample and high-quality RCT
studies are needed to further clarify the improvement effect of natto on osteoporosis.
Type of Medium:
Online Resource
ISSN:
0929-8673
DOI:
10.2174/0929867327666200306123140
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3
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