In:
Pharmacology, S. Karger AG, Vol. 86, No. 5-6 ( 2010), p. 273-280
Abstract:
This study examined the inhibitory effects of papaverine on twitches directly elicited by electrical stimulation of the mouse diaphragm. Papaverine (3–100 µ 〈 i 〉 M 〈 /i 〉 ) inhibited twitches in a dose-dependent manner. Papaverine increased the cyclic adenosine monophosphate (cAMP) but not cyclic guanosine monophosphate (cGMP) content. IBMX, Db-cAMP and 8-br-cGMP did not affect twitches, whereas verapamil and NaCN inhibited twitches. Increases in extracellular Ca 〈 sup 〉 2+ 〈 /sup 〉 removed the twitch inhibition caused by verapamil but not that caused by papaverine. Papaverine (30 and 100 µ 〈 i 〉 M 〈 /i 〉 ) and NaCN (1 m 〈 i 〉 M 〈 /i 〉 ) decreased creatine phosphate and ATP contents. These results suggest that the relaxing effects of papaverine on mouse diaphragm are mainly due to inhibition of aerobic energy metabolism.
Type of Medium:
Online Resource
ISSN:
0031-7012
,
1423-0313
Language:
English
Publisher:
S. Karger AG
Publication Date:
2010
detail.hit.zdb_id:
1483550-2
SSG:
15,3
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