In:
Nihon Kyukyu Igakukai Zasshi: Journal of Japanese Association for Acute Medicine, Wiley, Vol. 30, No. 8 ( 2019-08), p. 221-226
Abstract:
Colchicum autumnale , a liliaceous bulb plant, contains colchicine, which is lethal to humans upon intake of ≥0.5mg/kg. We report the case of a 56–year–old woman who bought Colchicum bulbs on the internet and attempted suicide by consuming the bulbs. She was transported to our hospital 10h after Colchicum consumption with complaints of vomiting and diarrhea. We suspected colchicine poisoning and performed gastric lavage, and 50g of activated carbon was administered. From day 2, we continued to administer oral activated carbon at 90g/day. Her urine volume decreased to 0.3mL/kg/h. On day 6, her white blood cells decreased to 1,600/μL (neutrophils, 640/μL) and platelets decreased to 54,000/μL; therefore, we administered a G–CSF preparation. From day 1, her hepatobiliary enzyme level was elevated but gradually decreased after day 9, and the renal and bone marrow functions were restored; therefore, administration of activated carbon was terminated on day 9. Plasma colchicine levels were measured throughout the treatment course; it had reached a peak value (4.4ng/dL) on day 1, followed by a gradual decrease. On day 8, her colchicine levels were undetectable. This case suggests that reduction in colchicine levels is an indication of termination of activated carbon administration.
Type of Medium:
Online Resource
ISSN:
1883-3772
,
1883-3772
DOI:
10.1002/jja2.2019.30.issue-8
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2846771-1
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