In:
APMIS, Wiley, Vol. 126, No. 6 ( 2018-06), p. 486-493
Abstract:
Preoperative chemoradiotherapy ( CRT ) is a standard therapy for locally advanced rectal cancer; however, the response varies depending on cases. Therefore, CRT ‐response predictors need to be elucidated. Cancer stem cells ( CSC s), comprising a small part of tumors, are associated with tumor progression and recurrence due to their self‐renewal and proliferation abilities. Doublecortin‐like kinase 1 ( DCLK 1) is one of the several putative CSC markers; however, the clinical impact of its expression in rectal cancer has not been evaluated. The aim of this study was to clarify the clinical impact of DCLK 1 expression in rectal cancer. We immunohistochemically evaluated DCLK 1 expression in surgical specimens of 106 rectal cancer patients, including those who underwent preoperative CRT . The correlations between DCLK 1 expression, and clinicopathological features and patient prognosis were then assessed. In rectal cancer patients treated with preoperative CRT , DCLK 1 expression was significantly correlated with lymph node metastasis (p = 0.02) and poor cancer‐specific survival (p = 0.049). However, in patients treated without preoperative therapy, no such correlation was found. DCLK 1 expression can be associated with lymph node metastasis and poor cancer‐specific survival in rectal cancer patients who receive CRT .
Type of Medium:
Online Resource
ISSN:
0903-4641
,
1600-0463
DOI:
10.1111/apm.2018.126.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2098213-6
SSG:
12
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