In:
Liver International, Wiley, Vol. 34, No. 6 ( 2014-07), p. 942-952
Abstract:
The tumour cell microenvironment, which includes local oxygen saturation, pericellular pH and stromal cells, can modulate tumour progression. This study determined the prognostic impact of infiltrating tumour‐associated macrophages and the expression of monocarboxylate transporter 4 (MCT4) and glypican 3 (GPC3) in hepatocellular carcinoma (HCC) clinical specimens. Methods A total of 225 cases of resected HCC were subjected to immunohistochemical analyses of CD 68, CD 204, MCT 4 and GPC 3. Immunoreactivities and other common clinicopathological parameters were subjected to univariate prognostic analyses for overall survival ( OS , n = 225) and disease‐free survival ( DFS , n = 222). All variables with prognostic impact were further analysed in multivariate analysis. Results Increased intratumoural infiltration of CD 204‐positive or MCT 4‐positive macrophages suggested shorter OS ( P = 0.015 or P = 0.001 respectively), but DFS was not altered. The GPC 3 score (with an emphasis on circumferential immunoreactivity) was correlated with shorter OS and DFS . Aberrant expression of MCT 4 in HCC cells was observed in a subset of HCC cases (21%, 47/225). In those cases, significantly poorer OS ( P 〈 0.0001) and DFS ( P = 0.0003) were observed, and there was a positive correlation with the intratumoural infiltration of CD 204‐ or MCT 4‐positive macrophages and the GPC 3 score. Multivariate analysis showed that aberrant MCT 4 expression in HCC cells was an independent prognostic factor for shorter OS ( P = 0.018) and DFS ( P = 0.006) after resection of HCC . Conclusion Aberrant expression of MCT 4 in carcinoma cells serves as a novel, independent prognostic factor for HCC , indicating a poorer patient outcome.
Type of Medium:
Online Resource
ISSN:
1478-3223
,
1478-3231
DOI:
10.1111/liv.2014.34.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2124684-1
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