In:
Journal of Midwifery & Women's Health, Wiley, Vol. 54, No. 2 ( 2009-03-04), p. 133-141
Abstract:
The objective of this study was to compare a Tibetan traditional medicine (the uterotonic Zhi Byed 11 [ ZB11 ]) to oral misoprostol for prophylaxis of postpartum hemorrhage (PPH). We conducted a double‐blind randomized controlled trial at three hospitals in Lhasa, Tibet, People's Republic of China. Women (N = 967) were randomized to either ZB11 or misoprostol groups. Postpartum blood loss was measured in a calibrated blood collection drape. The primary combined outcome was incidence of PPH, defined as measured blood loss (MBL) ≥ 500 mL, administration of open label uterotonics, or maternal death. We found that the rate of the combined outcome was lower among the misoprostol group (16.1% versus 21.8% for ZB11; P = .02). Frequency of PPH was lower with misoprostol (12.4% versus 17.4%; P = .02). There were no significant differences in MBL 〉 1000 mL or mean or median MBL. Fever was significantly more common in the misoprostol group ( P = .03). The rate of combined outcome was significantly lower among women receiving misoprostol. However, other indices of obstetric hemorrhage were not significantly different.
Type of Medium:
Online Resource
ISSN:
1526-9523
,
1542-2011
DOI:
10.1016/j.jmwh.2008.09.010
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2027962-0
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