In:
Dermatology, S. Karger AG, Vol. 203, No. 2 ( 2001), p. 141-147
Kurzfassung:
〈 i 〉 Background: 〈 /i 〉 There are already many effective topical therapies available for use in the treatment of chronic plaque psoriasis. Unfortunately, these treatments are often associated with a rather significant risk of undesirable effects. 〈 i 〉 Objective and Methods: 〈 /i 〉 In this randomized, prospective clinical trial, the effects of the vitamin D 〈 sub 〉 3 〈 /sub 〉 analog calcipotriol were evaluated against those of a recently developed vitamin B 〈 sub 〉 12 〈 /sub 〉 cream containing avocado oil in an intraindividual right/left-side comparison. The trial population consisted of 13 patients, 10 men and 3 women, with chronic plaque psoriasis. The observation period was 12 weeks; the effects of therapy were assessed on the basis of a PASI score adapted to the right/left-side comparison technique, the subjective evaluations of the investigator and patients and the results of 20-MHz sonography. 〈 i 〉 Results: 〈 /i 〉 There was a more rapid development of beneficial effects with the use of calcipotriol in the initial 8 weeks, although differences in effects were significant only at the time point of therapy week 8 (p 〈 0.05). After 12 weeks, neither the PASI score nor 20-MHz sonography showed significant differences between the two treatments. While the efficacy of the calcipotriol preparation reached a maximum in the first 4 weeks and then began to subside, the effects of the vitamin B 〈 sub 〉 12 〈 /sub 〉 cream containing avocado oil remained at a constant level over the whole observation period. This would indicate that the vitamin B 〈 sub 〉 12 〈 /sub 〉 preparation containing avocado oil may be suitable for use in long-term therapy, a hypothesis further supported by the fact that the investigator and the patients assessed the tolerability of the vitamin B 〈 sub 〉 12 〈 /sub 〉 cream containing avocado oil as significantly better in comparison with that of calcipotriol. 〈 i 〉 Conclusion: 〈 /i 〉 The results of this clinical trial provide evidence that the recently developed vitamin B 〈 sub 〉 12 〈 /sub 〉 cream containing avocado oil has considerable potential as a well-tolerated, long-term topical therapy of psoriasis.
Materialart:
Online-Ressource
ISSN:
1018-8665
,
1421-9832
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2001
ZDB Id:
1482189-8
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