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  • 1
    Online Resource
    Online Resource
    Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh
    Springer Science and Business Media LLC ; 2010
    In:  Environmental Health Vol. 9, No. 1 ( 2010-12)
    Details
    In: Environmental Health, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2010-12)
    Abstract: Arsenic is a potent pollutant that has caused an environmental catastrophe in certain parts of the world including Bangladesh where millions of people are presently at risk due to drinking water contaminated by arsenic. Chronic arsenic exposure has been scientifically shown as a cause for liver damage, cancers, neurological disorders and several other ailments. The relationship between plasma cholinesterase (PChE) activity and arsenic exposure has not yet been clearly documented. However, decreased PChE activity has been found in patients suffering liver dysfunction, heart attack, cancer metastasis and neurotoxicity. Therefore, in this study, we evaluated the PChE activity in individuals exposed to arsenic via drinking water in Bangladesh. Methods A total of 141 Bangladeshi residents living in arsenic endemic areas with the mean arsenic exposure of 14.10 ± 3.27 years were selected as study subjects and split into tertile groups based on three water arsenic concentrations: low ( 〈 129 μg/L), medium (130-264 μg/L) and high ( 〉 265 μg/L). Study subjects were further sub-divided into two groups (≤50 μg/L and 〉 50 μg/L) based on the recommended upper limit of water arsenic concentration (50 μg/L) in Bangladesh. Blood samples were collected from the study subjects by venipuncture and arsenic concentrations in drinking water, hair and nail samples were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). PChE activity was assayed by spectrophotometer. Results Arsenic concentrations in hair and nails were positively correlated with the arsenic levels in drinking water. Significant decreases in PChE activity were observed with increasing concentrations of arsenic in water, hair and nails. The average levels of PChE activity in low, medium and high arsenic exposure groups were also significantly different between each group. Lower levels of PChE activity were also observed in the 〉 50 μg/L group compared to the ≤50 μg/L group. Moreover, PChE activity was significantly decreased in the skin (+) symptoms group compared to those without (-). Conclusions We found a significant inverse relationship between arsenic exposure and PChE activity in a human population in Bangladesh. This research demonstrates a novel exposure-response relationship between arsenic and PChE activity which may explain one of the biological mechanisms through which arsenic exerts its neuro-and hepatotoxicity in humans.
    Type of Medium: Online Resource
    ISSN: 1476-069X
    URL: Article
    DOI: 10.1186/1476-069X-9-36
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2010
    detail.hit.zdb_id: 2092232-2
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  • 2
    Online Resource
    Online Resource
    Effect of Spinal Anaesthesia in Children of 4-10 Years
    Bangladesh Academy of Sciences ; 2017
    In:  Journal of Enam Medical College Vol. 7, No. 1 ( 2017-01-30), p. 10-14
    Details
    In: Journal of Enam Medical College, Bangladesh Academy of Sciences, Vol. 7, No. 1 ( 2017-01-30), p. 10-14
    Abstract: Background: Though paediatric spinal anaesthesia has been used since early 20th century in developed countries even in neonates, still it is not common in our country. Spinal anaesthesia can be given in neonates and children for infraumbilical surgeries with an expert and experienced anaesthesiologist.Objective: The objective of this study was to establish spinal anaesthesia as a safe and effective regional anaesthetic procedure in children of 410 years.Materials and Methods: The study was done in the Department of Anaesthesiology & Intensive Care Unit of Enam Medical College & Hospital during the period of June 2012 to May 2014. A total of 102 patients aged from 4 to 10 years with American Society of Anaesthesiologists (ASA)-I and II were selected. After proper preoperative anaesthetic evaluation spinal anaesthesia was administered. All patients were premedicated with atropine, preloaded with crystalloid solution and sedated with ketamine 1 mg/kg or midazolam 0.03 mg/kg. 0.5% hyperberic bupivacaine was injected at L4/5 or L5/S1 level with spinocaine needle. After establishment of desired block, surgery was performed. All vital parameters, number of attempts for lumbar puncture, sensory and motor block were monitored and recorded.Results: Almost all patients achieved desired block (T8T10) within 5 to 10 minutes. The success rate in our study was 96.1% and remaining 3.9% were considered as failure. No remarkable changes were observed in vital parameters after spinal anaesthesia. Lumbar puncture was successful in first attempt in 60 (58.82%) cases and in second attempt in 42 (41.18%) cases. Hypotension occurred in 2%, shivering in 3% and 3% developed restlessness.Conclusion: Spinal anaesthesia produces a reliable, profound and uniformly distributed block with rapid onset, good muscle relaxation, complete control of cardiovascular and stress responses compared with epidural or GA. There is also rapid recovery and minimal complications without special drugs or expensive equipments. However, greater acceptance and experience are still desired for this technique to become more popular.J Enam Med Col 2017; 7(1): 10-14
    Type of Medium: Online Resource
    ISSN: 2304-9316 , 2227-6688
    URL: Article
    DOI: 10.3329/jemc.v7i1.30744
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2017
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  • 3
    Online Resource
    Online Resource
    Euphorbia neriifolia Leaf Juice on Mild and Moderate COVID-19 Patients: Implications in OMICRON Era
    Jaypee Brothers Medical Publishing ; 2022
    In:  Euroasian Journal of Hepato-Gastroenterology Vol. 12, No. 1 ( 2022-07-13), p. 10-18
    Details
    In: Euroasian Journal of Hepato-Gastroenterology, Jaypee Brothers Medical Publishing, Vol. 12, No. 1 ( 2022-07-13), p. 10-18
    Type of Medium: Online Resource
    ISSN: 2231-5047 , 2231-5128
    URL: Article
    DOI: 10.5005/jp-journals-10018-1367
    Language: English
    Publisher: Jaypee Brothers Medical Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2651614-7
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  • 4
    Online Resource
    Online Resource
    Efficacy, Safety and tolerability of the once-daily 10 cm² rivastigmine patch formulation in the patients with dementia (with probable Alzheimer’s disease)
    Bangladesh Academy of Sciences ; 2013
    In:  Bangladesh Journal of Neuroscience Vol. 29, No. 1 ( 2013-01-31), p. 5-14
    Details
    In: Bangladesh Journal of Neuroscience, Bangladesh Academy of Sciences, Vol. 29, No. 1 ( 2013-01-31), p. 5-14
    Abstract: Back ground: Treatment compliance in patients with Alzheimer’s disease is particularly important as patients receiving regular treatment have a greater chance of slowing or delaying disease progression. Transdermal delivery has the potential for providing continuous drug delivery and steady plasma levels. Current study aimed to evaluate safety and tolerability of rivastigmine patch, to assess patient compliance and to assess the efficacy of treatment in patients with dementia (with probable Alzheimer’s disease). Methods: A total of 112 dementia patients (with a diagnosis of probable Alzheimer’s disease) from 12 centers were enrolled who were residing with someone in the communities throughout the study. After eligibility, and baseline assessments, patients were entered a 24-week open label treatment phase. All patients were started with application of one 5 cm² patch, followed by an up-titration to the target dose of 10 cm² patch size. Efficacy assessments were performed at weeks 12 and 24 in terms of MMSE and GDS score. Safety was monitored at all assessment points based mainly on the frequency of adverse events. Results: Analysis of baseline and available data until the drop out revealed no significant differentials. Around 95% of the study participants could receive 10 cm² patch size, showing a very high tolerability of the patch. Concurrent medication use also showed significant reduction to 16.3% patient in the end from 25% at baseline. The average MMSE score increased to 19.3 (±3.1) at 12th week and to 20.6(±3.4) at 24th week from 16.8 (±3.2) at baseline. GDS score reduced to 3.7 (±1.4) at 12th week and to 3.2 (±1.3) at 24th week from 4.3 (±1.5) at baseline. Only eight occasions of adverse event was reported (8.2%); no serious adverse event (SAE) were reported. Lost to follow up in the study was 14 (12.5%). Analysis of baseline data shows no significant difference. Their withdrawal seems to be unrelated to the adverse events and treatment outcome. Among the lost to follow up only one 1 (7.1%) had some side effect. Conclusion: Our study supports the pharmacokinetic rationale for the rivastigmine patch, indicating that smooth and continuous delivery of rivastigmine translates into an improved tolerability profile versus conventional oral administration, while maintaining clinical effectiveness. Bangladesh Journal of Neuroscience 2013; Vol. 29 (1) : 5-14
    Type of Medium: Online Resource
    ISSN: 2408-8382 , 1023-4853
    URL: Article
    DOI: 10.3329/bjn.v29i1.56165
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2013
    detail.hit.zdb_id: 2573887-2
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  • 5
    Online Resource
    Online Resource
    Comparison of Effect of Conventional Medical Management and Ivabradine with Conventional Medical Management on Quality of Life in Patients with Chronic Heart Failure
    Bangladesh Academy of Sciences ; 2023
    In:  TAJ: Journal of Teachers Association Vol. 36, No. 1 ( 2023-08-24), p. 1-8
    Details
    In: TAJ: Journal of Teachers Association, Bangladesh Academy of Sciences, Vol. 36, No. 1 ( 2023-08-24), p. 1-8
    Abstract: Background: The study aimed to see the effectiveness and role of ivabradine on the quality of life in chronic heart failure suffering patients. This open-label Randomized controlled Trial was conducted to assess the effect of ivabradine plus conventional medical management over conventional medical management on quality-of-life parameters among 100 patients of chronic heart failure from January 2021 to December 2021 in the Department of Pharmacology & Therapeutics in collaboration with the Department of Cardiology & Medicine, Rajshahi Medical College Hospital, Rajshahi. Materials and methods: According to the drug allocation study population was divided into a control group (50 patients) and an experimental group (50 patients). Minnesota Living with Heart Failure questionnaire (MLWHFQ) was used to assess the quality of life, and the resting heart rate was measured by 12-lead electrocardiography. Baseline demographic and clinical characteristics were recorded, and patients were followed up at four weeks and 12 weeks of treatment. Results: The comparison of mean differences of MLWHFQ score at first and second follow-up visits between the two study groups was statistically significant [t (100) = 2.43 p 〈 0.05 & t (100) = 6.60 p 〈 0.001 respectively]. According to the MLWHFQ cut-point score, it was also observed that poor baseline quality of life gradually shifted to good quality after four weeks and 12 weeks of treatment, and it was proportionately higher in the experimental group. Relations between the respondents of both study groups and their different qualities of life during the first follow-up visit (x2 = 13.69, df = 2, p 〈 0.05) and second follow-up visit (x2 = 22.79, df = 2, p 〈 0.001) were statistically significant.The comparison of the mean (±SD) heart rate between the two study groups was statistically significant (p 〈 0.001) only during the second follow-up visit. Conclusion: This study concluded that adding ivabradine to conventional medical management in treating patients with chronic heart failure improves their symptoms, quality of life, and heart rate and ultimately reduces the morbidity and mortality of such patients. TAJ 2022; 36: No-1: 1-8
    Type of Medium: Online Resource
    ISSN: 2408-8854 , 1019-8555
    URL: Article
    DOI: 10.3329/taj.v36i1.68273
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2023
    detail.hit.zdb_id: 2754944-6
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  • 6
    Online Resource
    Online Resource
    Higher risk of hyperglycemia with greater susceptibility in females in chronic arsenic-exposed individuals in Bangladesh
    Elsevier BV ; 2019
    In:  Science of The Total Environment Vol. 668 ( 2019-06), p. 1004-1012
    Details
    In: Science of The Total Environment, Elsevier BV, Vol. 668 ( 2019-06), p. 1004-1012
    Type of Medium: Online Resource
    ISSN: 0048-9697
    URL: Article
    DOI: 10.1016/j.scitotenv.2019.03.029
    RVK:
    AR 10100
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 1498726-0
    detail.hit.zdb_id: 121506-1
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Evaluation of Efficacy of Oral Prednisolone in the Treatment of Acute Bronchiolitis in a Tertiary Level Hospital in Rajshahi
    Bangladesh Academy of Sciences ; 2022
    In:  TAJ: Journal of Teachers Association Vol. 34, No. 2 ( 2022-03-08), p. 95-101
    Details
    In: TAJ: Journal of Teachers Association, Bangladesh Academy of Sciences, Vol. 34, No. 2 ( 2022-03-08), p. 95-101
    Abstract: Bronchiolitis is a viral infection of lower respiratory tract that occurs most commonly in young children ( 〈 2years). It is one of the most common cause of hospitalization of infants. It has a major public health hazard throughout the world exerting significant morbidity and mortality. Methods: This randomized controlled trial study was conducted in the Department of pediatrics, Rajshahi Medical College Hospital. Total 120 patients with acute bronchiolitis were selected who were less than two years of age. Two groups were randomly selected by lottery method. One group was given salbutamol along with prednisolone (Experimental group) another was only salbutamol (Placebo group) to compare the efficacy and evaluate the outcome of both treatment groups. Result: The mean age of the experimental group was7.09±4.71 months and mean age of placebo group was 5.70±4.26 months. The majority number of patients 96(80%) came from middle class family with 30(25%) houses with crowded conditions. About 16(13.3%) patients were born in preterm condition and 18(15%) were low birth weight. Among the family members 21(17.5%) had asthma and 43(35.18%) had smoking history. After treatment notable outcome clinically observed after 3 days of treatment in experimental than placebo group (p-value 〈 0.05). Oral prednisolone reduces 1-2 days of hospital stay (p- value 〈 0.001) compared to placebo group. The use of prednisolone reduces the severity of disease more rapidly in association with placebo group (p - value 〈 0.001). Conclusions: Bronchiolitis is one of the most common disease in the young children and is the frequent reason for hospitalization. Prednisolone is useful in the reducing hospital stay and improving respiratory symptoms. TAJ 2021; 34: No-2: 95-101
    Type of Medium: Online Resource
    ISSN: 2408-8854 , 1019-8555
    URL: Article
    DOI: 10.3329/taj.v34i2.58561
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2022
    detail.hit.zdb_id: 2754944-6
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  • 8
    Online Resource
    Online Resource
    Impact of Infant and Young Child Feeding Practices on the Nutritional Status of Children in Northern Bangladesh
    Bangladesh Academy of Sciences ; 2023
    In:  TAJ: Journal of Teachers Association Vol. 35, No. 2 ( 2023-01-04), p. 83-91
    Details
    In: TAJ: Journal of Teachers Association, Bangladesh Academy of Sciences, Vol. 35, No. 2 ( 2023-01-04), p. 83-91
    Abstract: Background: Proper feeding practices are essential for attaining and maintaining optimum nutrition, health, and development of infants and children. Exclusive breastfeeding during the first six months of life and continued breastfeeding for two years, together with age-appropriate, nutritionally adequate complementary feeding initiated after six months of age, are optimum Infant and Young Child Feeding (IYCF) practices. However, often many aspects of infant and young child feeding practices are not optimum, with serious consequences for the child. Objective: To determine the impact of Infant and Young Child Feeding (IYCF) practices on the nutritional status of children.  Materials and Method: This Cross-sectional descriptive type of study was conducted among 314 children from 6 months to 24 months of age at the Pediatric Outpatient Department and EPI center of Rajshahi Medical College Hospital during the period of January 2017 to December 2018. Collected data were analyzed by using 'SPSS version 16. Result: Among 314 children exclusive breastfeeding (EBF) rate was 68.2% for the first six months, and timely started complementary feeding was 58.5% of cases. In 214 exclusive breastfed infants, only 4.7% and 1.4% of children were moderate to severely wasted and stunted, respectively. On the other hand, among 97 infants who were not exclusively breastfed, the percentage of moderate to severe wasting and stunting was 11.4% and 13.4%, respectively. Among the 175 timely started complementary feeding children, only 12% and 6% were moderate to severely underweight and wasted, respectively, no one was stunted, but among the inappropriately started complementary children, 20.2%, 12.5%, and 12.8% were moderately to severely underweight, wasted and stunted respectively. Conclusion: Most of the children who were given exclusive breastfeeding in the first six months and started complementary food at an appropriate time after six months had normal nutritional status. Both moderate to severe stunting and wasting were common in those children who were non-exclusively breastfed and started complementary feeding either early or late. TAJ 2022; 35: No-2: 83-91
    Type of Medium: Online Resource
    ISSN: 2408-8854 , 1019-8555
    URL: Article
    DOI: 10.3329/taj.v35i2.63756
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2023
    detail.hit.zdb_id: 2754944-6
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  • 9
    Online Resource
    Online Resource
    Ni(II) complexes with in-situ generated N, O-bidentate aroylhydrazone Schiff base ligands: One-pot synthesis, characterization, crystal structure, and in-silico studies
    Elsevier BV ; 2024
    In:  Journal of Molecular Structure Vol. 1295 ( 2024-01), p. 136698-
    Details
    In: Journal of Molecular Structure, Elsevier BV, Vol. 1295 ( 2024-01), p. 136698-
    Type of Medium: Online Resource
    ISSN: 0022-2860
    URL: Article
    DOI: 10.1016/j.molstruc.2023.136698
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 1491504-2
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  • 10
    Online Resource
    Online Resource
    Demographic Pattern of Alzheimer’s Disease in Bangladesh
    Bangladesh Academy of Sciences ; 2019
    In:  Bangladesh Journal of Neuroscience Vol. 35, No. 1 ( 2019-01-31), p. 10-13
    Details
    In: Bangladesh Journal of Neuroscience, Bangladesh Academy of Sciences, Vol. 35, No. 1 ( 2019-01-31), p. 10-13
    Abstract: Background: AD is the most common cause of dementia in elderly which causes economic burden for the affected individual, caregivers and society. The objective of this study was to see demographic characteristics among AD patients and it will provide magnitude of the problem and planning of health programme for prevention of disease. Methods: This observational analytical study was carried out in the Neurology ward, OPD and Dementia clinic of BSMMU, Dhaka from May’ 15 to February’ 17. A total of 45 patients were recruited as study population after satisfying all the criteria for enrollment. Results: A total of 27 male and 18 female with mean age of 69.20 ± 11.16 years, constituted as cases. Conclusion: The occurrence of AD found more after the age of 65 years. The present study found that lower educational level is associated with more chance of getting AD. Higher rate of Alzheimer’s disease was found in older man than women. Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 10-13
    Type of Medium: Online Resource
    ISSN: 2408-8382 , 1023-4853
    URL: Article
    DOI: 10.3329/bjn.v35i1.57619
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2019
    detail.hit.zdb_id: 2573887-2
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