In:
FEBS Letters, Wiley, Vol. 448, No. 1 ( 1999-04-02), p. 15-18
Abstract:
The promoter of the cholecystokinin (CCK) gene possesses evolutionary conserved juxtaposed E‐box and cAMP/TPA responsive elements (CRE/TRE). We have examined the functional interaction of these two sites. As previously noted, c‐Jun/c‐Fos heterodimers greatly increase promoter activity through association with the CRE/TRE. Mutation of the E‐box enhanced the activation by c‐Jun/c‐Fos, as well as stimulation by forskolin and bFGF, that acts through the CRE/TRE site. Moreover, c‐Jun/c‐Fos stimulation was inhibited by co‐expression of c‐Myc and Max. The results indicate that factors associating with the E‐box exhibit a negative cooperative effect on the activation via the CRE/TRE element. We propose that this mechanism plays a significant role in CCK gene transcription and other genes with juxtaposed E‐box and CRE/TRE.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(99)00320-8
Language:
English
Publisher:
Wiley
Publication Date:
1999
detail.hit.zdb_id:
1460391-3
SSG:
12
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