In:
Biomaterials Science, Royal Society of Chemistry (RSC), Vol. 9, No. 22 ( 2021), p. 7591-7602
Abstract:
Photothermal therapy (PTT), as a promising antineoplastic therapeutic strategy, has been harnessed to restrain tumor growth through near-infrared (NIR) irradiation mediated thermal ablation. Nevertheless, its biological applications are hampered by thermal diffusion and up-regulated heat shock proteins (HSPs). Herein, a versatile nanotheranostic agent is developed via integrating Zn 0.2 Fe 2.8 O 4 nanoparticles (NPs), polydopamine (PDA), and MnO 2 NPs for T 1/ T 2 dual-modal magnetic resonance (MR) imaging-guided and self-augmented PTT. The as-designed Zn 0.2 Fe 2.8 O 4 @PDA@MnO 2 NPs adequately serve as a PTT agent to realize effective photothermal conversion and obtain local hyperthermia. Additionally, the Zn 0.2 Fe 2.8 O 4 @PDA@MnO 2 NPs can significantly consume overexpressed glutathione (GSH) and generate Mn 2+ in the tumor microenvironment (TME), thus destroying redox homeostasis and catalytically generating hydroxyl radicals (˙OH) for HSP suppression and PTT enhancement. Meanwhile, Mn 2+ and Zn 0.2 Fe 2.8 O 4 NPs significantly strengthen T1- and T2-weighted MR contrast for tumor imaging and PTT guidance. Hence, this study offers proof of concept for self-augmented PTT and T 1/ T 2 dual-modal MR imaging for tumor elimination.
Type of Medium:
Online Resource
ISSN:
2047-4830
,
2047-4849
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2021
detail.hit.zdb_id:
2693928-9
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