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  • 1
    Online Resource
    Online Resource
    Antibiotics Resistance in Escherichia coli Isolated from Livestock in the Emirate of Abu Dhabi, UAE, 2014–2019
    Hindawi Limited ; 2022
    In:  International Journal of Microbiology Vol. 2022 ( 2022-4-26), p. 1-10
    Details
    In: International Journal of Microbiology, Hindawi Limited, Vol. 2022 ( 2022-4-26), p. 1-10
    Abstract: Escherichia coli (E. coli) is a zoonotic pathogen that showed growing resistance to antibiotics. No descriptive analysis highlights the threat of antimicrobial-resistant (AMR) of E. coli among livestock in the United Arab Emirates (UAE). Herein, we conducted phenotypic and genotypic resistance studies on E. coli isolates from livestock samples in the Emirate of Abu Dhabi based on routine diagnosis between the periods 2014–2019. Bacterial culture and disk diffusion methods were used for bacterial isolation and phenotypic resistance analysis. Resistance mechanism was studied by PCR targeting the most commonly resistance genes: ampicillin (blaSHV, blaCMY, and blaTEM-1B), tetracyclines (tetA and tetB), co-trimoxazole [sulfamethoxazole (sul1, sul2, and sul3) + trimethoprim (dfrA1 and dfrA17)], aminoglycosides [aph(3'')-Ia, aph(6)-Id, and aac(3)-IV] , and fluoroquinolones (qnrA and aac(6’)-Ib-cr). Analysis of 165 E. coli isolates showed resistant to ampicillin, tetracycline, co-trimoxazole, gentamicin, and enrofloxacin by 157/165 (95.4%), 154/165 (93.6%), 141/165 (86%), 139/165 (85%), and 135/165 (82.7%), respectively. Predominant resistance gene/s detected by PCR were blaCMY (119/160, 72%) and blaTEM-1B (154/160, 96.3%) for ampicillin; tetA (162/164, 98.8%) and tetB (112/164, 68.3%) for tetracyclines; sul2 (156/164, 95%), sul3 (138/164, 84%), and dfra17 (74/164, 44.5%) for co-trimoxazole; aph(3'')-Ia (134/164, 82.1%) and aph(6)-Id (161/164, 98.2%) for aminoglycosides; and aac(6’)-Ib-cr (61/61, 100%) for enrofloxacin. Both phenotypic and genotypic analyses revealed that all E. coli isolates were multidrug-resistant (resistance to 3, 4, and 5 antibiotics classes by 3.6%, 57.6%, and 38.8%, respectively) carrying one or more resistance gene/s for the same antibiotic. PCR profiling confirmed the presence of resistance genes corresponding to their antibiotic profile. Results of the study will highlight the knowledge based on E. coli AMR related to livestock in UAE that may call for interventions.
    Type of Medium: Online Resource
    ISSN: 1687-9198 , 1687-918X
    URL: Article
    DOI: 10.1155/2022/3411560
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2467270-1
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  • 2
    Online Resource
    Online Resource
    A Rare Pediatric Case Report With Review of Literature for the Diagnosis of Acute Megakaryoblastic Leukemia (FAB M7)
    HATASO Enterprises LLC ; 2021
    In:  Recent Advances in Biology and Medicine Vol. 7, No. 3 ( 2021-08-16), p. 1-6
    Details
    In: Recent Advances in Biology and Medicine, HATASO Enterprises LLC, Vol. 7, No. 3 ( 2021-08-16), p. 1-6
    Abstract: Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia (AML) accounting for 3%–10% of primary AML in childhood. Clinical manifestations of AML patients can include low grade of fever, diarrhea, easy bruising, failure to growth, and life-threatening clinical manifestations. Laboratory tests are very crucial to make a definitive diagnosis and treatment. We report here an uncommon case of AMKL in a 12-month-old boy who presented with general paleness and fatigue. Based on blood film investigation, bone marrow examination report, and immunophenotyping, he was diagnosed as a case of AMKL without Down syndrome.
    Type of Medium: Online Resource
    ISSN: 2378-654X
    URL: Article
    DOI: 10.18639/RABM.2021.1443014
    Language: English
    Publisher: HATASO Enterprises LLC
    Publication Date: 2021
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  • 3
    Online Resource
    Online Resource
    Performance Analysis of Wavelet Transform De-noising Technique in Partial Discharge Signal based on Various Types of Mother Wavelet Via LabVIEW Software
    Institute of Advanced Scientific Research ; 2019
    In:  Journal of Advanced Research in Dynamical and Control Systems Vol. 11, No. 12-SPECIAL ISSUE ( 2019-12-31), p. 885-893
    Details
    In: Journal of Advanced Research in Dynamical and Control Systems, Institute of Advanced Scientific Research, Vol. 11, No. 12-SPECIAL ISSUE ( 2019-12-31), p. 885-893
    Type of Medium: Online Resource
    ISSN: 1943-023X , 1943-023X
    Uniform Title: Performance Analysis of Wavelet Transform De-noising Technique in Partial Discharge Signal based on Various Types of Mother Wavelet Via LabVIEW Software
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.5373/JARDCS/V11SP12
    DOI: 10.5373/JARDCS
    DOI: 10.5373/JARDCS/V11SP12/20193289
    Language: Unknown
    Publisher: Institute of Advanced Scientific Research
    Publication Date: 2019
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  • 4
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    The correlation between severe complications and blood group types in COVID-19 patients; with possible role of T polyagglutination in promoting thrombotic tendencies
    American Institute of Mathematical Sciences (AIMS) ; 2023
    In:  AIMS Medical Science Vol. 10, No. 1 ( 2023), p. 1-13
    Details
    In: AIMS Medical Science, American Institute of Mathematical Sciences (AIMS), Vol. 10, No. 1 ( 2023), p. 1-13
    Abstract: 〈abstract〉〈sec〉 〈title〉Introduction〈/title〉 〈p〉Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still posing detrimental effects on people. An association between contracting COVID-19 and the ABO blood group type has been determined. However, factors that determine the severity of COVID-19 are not yet fully understood. Thus, the current study aimed to investigate whether the ABO blood group type has a role in the severity of complications due to COVID-19.〈/p〉 〈/sec〉〈sec〉 〈title〉Materials and methods〈/title〉 〈p〉Eighty-Six ICU-admitted COVID-19 patients and 80 matched-healthy controls were recruited in the study from Baish general hospital, Saudi Arabia. ABO blood grouping, complete blood count (CBC), CBC-derived inflammatory markers, coagulation profile, D-Dimer and anti-T antigen were reported.〈/p〉 〈/sec〉〈sec〉 〈title〉Results〈/title〉 〈p〉Our data showed that patients with blood groups O and B are more protective against severe complications from COVID-19, as compared to patients with blood groups A and AB. This could be partially attributed to the presence of anti-T in blood group A individuals, compared to non-blood group A.〈/p〉 〈/sec〉〈sec〉 〈title〉Conclusion〈/title〉 〈p〉The current study reports an association between the ABO blood group and the susceptibility to severe complications from COVID-19, with a possible role of anti-T in driving the mechanism of the thrombotic tendency, as it was also correlated with an elevation in D-dimer levels.〈/p〉 〈/sec〉〈/abstract〉
    Type of Medium: Online Resource
    ISSN: 2375-1576
    URL: Article
    DOI: 10.3934/medsci.2023001
    Language: Unknown
    Publisher: American Institute of Mathematical Sciences (AIMS)
    Publication Date: 2023
    detail.hit.zdb_id: 2813969-0
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  • 5
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    Online Resource
    MODELLING OF PARTIAL DISCHARGE ANALYSIS SYSTEM USING WAVELET TRANSFORM DENOISING TECHNIQUE IN LABVIEW ENVIRONMENT
    Penerbit UTM Press ; 2019
    In:  Jurnal Teknologi Vol. 81, No. 6 ( 2019-09-22)
    Details
    In: Jurnal Teknologi, Penerbit UTM Press, Vol. 81, No. 6 ( 2019-09-22)
    Abstract: Partial discharge (PD) measurement is an essential to detect and diagnose the existence of the PD. However, this measurement has faced noise disturbance in industrial environments. Thus, PD analysis system using discrete wavelet transform (DWT) denoising technique via Laboratory Virtual Instrument Engineering Workbench (LabVIEW) software is proposed to distinguish noise from the measured PD signal. In this work, the performance of denoising process is analyzed based on calculated mean square error (MSE) and signal to noise ratio (SNR). The result is manipulated based on Haar, Daubechies, Coiflets, Symlets and Biorthogonal type of mother wavelet with different decomposition levels. From the SNR results, all types of the mother wavelet are suitable to be used in denoising technique since the value of SNR is in large positive value. Therefore, further studies were conducted and found out that db14, coif3, sym5 and bior5.5 wavelets with least MSE value are considered good to be used in the denoising technique. However, bior5.5 wavelet is proposed as the most optimum mother wavelet due to consistency of producing minimum value of MSE and followed by db14.
    Type of Medium: Online Resource
    ISSN: 2180-3722 , 0127-9696
    URL: Article
    DOI: 10.11113/jt.v81.13649
    Language: Unknown
    Publisher: Penerbit UTM Press
    Publication Date: 2019
    detail.hit.zdb_id: 2780014-3
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  • 6
    Online Resource
    Online Resource
    Molecular Determination of Vascular Endothelial Growth Factor, miRNA-423 Gene Abnormalities by Utilizing ARMS-PCR and Their Association with Fetal Hemoglobin Expression in the Patients with Sickle Cell Disease
    MDPI AG ; 2022
    In:  Current Issues in Molecular Biology Vol. 44, No. 6 ( 2022-06-01), p. 2569-2582
    Details
    In: Current Issues in Molecular Biology, MDPI AG, Vol. 44, No. 6 ( 2022-06-01), p. 2569-2582
    Abstract: Recent studies have indicated that microRNA and VEGF are considered to be genetic modifiers and are associated with elevated levels of fetal haemoglobin HbF, and thus they reduce the clinical impact of sickle haemoglobin (HbS) patients. This cross-sectional study was performed on clinical confirmed subjects of SCD cases. miR-423-rs6505162 C 〉 T and VEGF-2578 C 〉 A genotyping was conducted by ARMS-PCR in SCD and healthy controls. A strong clinical significance was reported while comparing the association of miR-423 C 〉 T genotypes between SCD patients and controls (p = 0.031). The microRNA-423 AA genotype was associated with an increased severity of SCD in codominant model with odd ratio (OR = 2.36, 95% CI, (1.15–4.84), p = 0.018) and similarly a significant association was observed in recessive inheritance model for microRNA-423 AA vs (CC+CA) genotypes (OR = 2.19, 95% CI, (1.32–3.62), p 〈 0.002). The A allele was associated with SCD severity (OR = 1.57, 95% CI, (1.13–2.19), p 〈 0.007). The distribution of VEGF-2578 C 〉 A genotypes between SCD patients and healthy controls was significant (p 〈 0.013). Our results indicated that in the codominant model, the VEGF-2578-CA genotype was strongly associated with increased SCD severity with OR = 2.56, 95% CI, (1.36–4.82), p 〈 0.003. The higher expression of HbA1 (65.9%), HbA2 (4.40%), was reported in SCD patients carrying miR-423-AA genotype than miR-423 CA genotype in SCD patients carrying miR-423 CA genotype HbA1 (59.98%), HbA2 (3.74%) whereas SCD patients carrying miR-423 CA genotype has higher expression of HbF (0.98%) and HbS (38.1%) than in the patients carrying AA genotype HbF (0.60%), HbS (36.1%). ARMS-PCR has been proven to be rapid, inexpensive and is highly applicable to gene mutation screening in laboratories and clinical practices. This research highlights the significance of elucidating genetic determinants that play roles in the amelioration of the HbF levels that is used as an indicator of severity of clinical complications of the monogenic disease. Further well-designed studies with larger sample sizes are necessary to confirm our findings.
    Type of Medium: Online Resource
    ISSN: 1467-3045
    URL: Article
    DOI: 10.3390/cimb44060175
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2090836-2
    SSG: 12
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  • 7
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    Online Resource
    The Role of Clinical Pharmacy in Preventing Prescribing Errors in the Emergency Department of a Governmental Hospital in Jordan: A Pre-Post Study
    SAGE Publications ; 2021
    In:  Hospital Pharmacy Vol. 56, No. 6 ( 2021-12), p. 681-689
    Details
    In: Hospital Pharmacy, SAGE Publications, Vol. 56, No. 6 ( 2021-12), p. 681-689
    Abstract: Background: Clinical pharmacists have a vital role in intercepting prescribing errors (PEs) but their impact within a Jordanian hospital emergency department (ED) has never been studied. Objective: To evaluate the impact of clinical pharmacy services on PEs and assess predictors of physicians’ acceptance of clinical pharmacists’ interventions. Setting: This study was conducted in the ED of the largest governmental hospital in Jordan. Method: This was a pre-post study conducted in October and November 2019 using a disguised observational method. There were 2 phases: control phase (P0) with no clinical interventions, and active phase (P1) where clinical pharmacists prospectively intervened upon errors. The clinical significance of errors was determined by a multidisciplinary committee. The SPSS software version 24 was used for data analysis. Main Outcome Measure: PEs incidence, type, severity, and predictors for physicians’ acceptance. Results: Of 18003 patients, 8732 were included in P0 and 9271 in P1. PEs incidence decreased from 24.6% to 5.4%. Contraindication, drug selection, and dosage form error types were significantly reduced from 32.6%, 9.1%, and 3.7% (P0) to 12.6%, 0.0%, and 0.0% (P1), respectively. Albeit not statistically significant, drug-drug interaction, drug frequency, and allergy error types were reduced from 4.9%, 3.1%, and 0.1% to 4.5%, 2.5%, and 0.0%, respectively. Significant and serious errors were significantly reduced from 68.7% and 3.0% (P0) to 8.9% and 1.8% (P1), respectively. During P1, most errors were minor (89.3%, 1574/1763), and lethal errors ceased. Predictors for physicians’ acceptance were: significant errors (OR 3.1; 95% CI 2.6-4.3; P = 0.03) and non-busy physicians (OR 2.1; 95% CI 1.6-2.7; P = 0.04). Conclusion: Clinical pharmacists significantly reduced PEs in the ED by 76%; most of interventions were significant. Policymakers are advised to implement active clinical pharmacy in the ED.
    Type of Medium: Online Resource
    ISSN: 0018-5787 , 1945-1253
    URL: Article
    DOI: 10.1177/0018578720942231
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2069227-4
    SSG: 15,3
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  • 8
    Online Resource
    Online Resource
    Clinical, Endoscopic, and Radiologic Features of Three Subtypes of Achalasia, Classified Using High-Resolution Manometry
    Medknow ; 2015
    In:  Saudi Journal of Gastroenterology Vol. 21, No. 3 ( 2015), p. 152-
    Details
    In: Saudi Journal of Gastroenterology, Medknow, Vol. 21, No. 3 ( 2015), p. 152-
    Type of Medium: Online Resource
    ISSN: 1319-3767
    URL: Article
    DOI: 10.4103/1319-3767.157560
    Language: English
    Publisher: Medknow
    Publication Date: 2015
    detail.hit.zdb_id: 2270229-5
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  • 9
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    Impact of COVID-19 on Blood Donation and Supply: A Multicenter Cross-Sectional Study from Saudi Arabia
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-1-12), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-1-12), p. 1-8
    Abstract: Background. The coronavirus disease-19 (COVID-19) pandemic caused a major impact on blood donation process and supply globally. A lockdown management procedure was launched nationally in Saudi Arabia to manage this global health crisis. The main aim of this study was to determine the effect of COVID-19 lockdown on blood donation services and supply in different regions of Saudi Arabia. Study Design and Methods. A retrospective cross-sectional study was conducted in the blood bank centers of 5 major cities including Riyadh, Jeddah, Dammam, Hail, and Jizan in Saudi Arabia. Demographic and blood characteristics were retrieved from the first 6 months of 2019 (January–June) and compared to the same period of 2020. Results. Our findings showed variation in the characteristics of blood donation and supply among the centers surveyed, as some of these centers were adversely affected, while others showed an increase in the availability of blood products during the pandemic. For example, Jeddah’s center was significantly affected by COVID-19 lockdown whereas Hail’s center showed a significant increase in the analyzed characteristics of blood donation services in 2020 compared to 2019. Overall, there was no major difference among the surveyed centers between 2020 and 2019, and this might be due to the effective management of blood supply and transfusion. Discussion. Although blood supply and transfusion practice was slightly affected at various degree among the surveyed centers, the whole process did not show a significant effect on the overall outcome. This is in fact due to the proper preparedness, management of blood requirements and supplies, and efficient response of the surveyed centers in Saudi Arabia.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/1474426
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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  • 10
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    Online Resource
    The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
    American Association for the Advancement of Science (AAAS) ; 2022
    In:  Science Vol. 378, No. 6615 ( 2022-10-07)
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 378, No. 6615 ( 2022-10-07)
    Abstract: Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century. Expanse of SARS-CoV-2 sequencing capacity in Africa. ( A ) African countries (shaded in gray) and institutions (red circles) with on-site sequencing facilities that are capable of producing SARS-CoV-2 whole genomes locally. ( B ) The number of SARS-CoV-2 genomes produced per country and the proportion of those genomes that were produced locally, regionally within Africa, or abroad. ( C ) Decreased turnaround time of sequencing output in Africa to an almost real-time release of genomic data.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.abq5358
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2022
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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