In:
Annual Review of Nutrition, Annual Reviews, Vol. 29, No. 1 ( 2009-08-01), p. 133-152
Abstract:
Recent years have brought a paradigm shift for the role of the essential trace element zinc in immunity. Although its function as a structural component of many enzymes has been known for decades, current experimental evidence points to an additional function of the concentration of free or loosely bound zinc ions as an intracellular signal. The activity of virtually all immune cells is modulated by zinc in vitro and in vivo. In this review, we discuss the interactions of zinc with major signaling pathways that regulate immune cell activity, and the implications of zinc deficiency or supplementation on zinc signaling as the molecular basis for an effect of zinc on immune cell function.
Type of Medium:
Online Resource
ISSN:
0199-9885
,
1545-4312
DOI:
10.1146/nutr.2009.29.issue-1
DOI:
10.1146/annurev-nutr-080508-141119
Language:
English
Publisher:
Annual Reviews
Publication Date:
2009
detail.hit.zdb_id:
1481486-9
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