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  • 1
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    Online Resource
    An integrated molecular risk score early in life for subsequent childhood asthma risk
    Wiley ; 2024
    In:  Clinical & Experimental Allergy
    Details
    In: Clinical & Experimental Allergy, Wiley
    Abstract: Numerous children present with early wheeze symptoms, yet solely a subgroup develops childhood asthma. Early identification of children at risk is key for clinical monitoring, timely patient‐tailored treatment, and preventing chronic, severe sequelae. For early prediction of childhood asthma, we aimed to define an integrated risk score combining established risk factors with genome‐wide molecular markers at birth, complemented by subsequent clinical symptoms/diagnoses (wheezing, atopic dermatitis, food allergy). Methods Three longitudinal birth cohorts (PAULINA/PAULCHEN, n = 190 + 93 = 283, PASTURE, n = 1133) were used to predict childhood asthma (age 5–11) including epidemiological characteristics and molecular markers: genotype, DNA methylation and mRNA expression (RNASeq/NanoString). Apparent (ap) and optimism‐corrected (oc) performance (AUC/R2) was assessed leveraging evidence from independent studies (Naïve‐Bayes approach) combined with high‐dimensional logistic regression models (LASSO). Results Asthma prediction with epidemiological characteristics at birth (maternal asthma, sex, farm environment) yielded an ocAUC = 0.65. Inclusion of molecular markers as predictors resulted in an improvement in apparent prediction performance, however, for optimism‐corrected performance only a moderate increase was observed (upto ocAUC = 0.68). The greatest discriminate power was reached by adding the first symptoms/diagnosis (up to ocAUC = 0.76; increase of 0.08, p = .002). Longitudinal analysis of selected mRNA expression in PASTURE (cord blood, 1, 4.5, 6 years) showed that expression at age six had the strongest association with asthma and correlation of genes getting larger over time ( r = .59, p 〈 .001, 4.5–6 years). Conclusion Applying epidemiological predictors alone showed moderate predictive abilities. Molecular markers from birth modestly improved prediction. Allergic symptoms/diagnoses enhanced the power of prediction, which is important for clinical practice and for the design of future studies with molecular markers.
    Type of Medium: Online Resource
    ISSN: 0954-7894 , 1365-2222
    URL: Article
    DOI: 10.1111/cea.14475
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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  • 2
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    Form follows function: Morphological and immunohistological insights into epithelial–mesenchymal transition characteristics of tumor buds
    IOS Press ; 2017
    In:  Tumor Biology Vol. 39, No. 5 ( 2017-05), p. 101042831770550-
    Details
    In: Tumor Biology, IOS Press, Vol. 39, No. 5 ( 2017-05), p. 101042831770550-
    Abstract: In cancer biology, the architectural concept “form follows function” is reflected by cell morphology, migration, and epithelial–mesenchymal transition protein pattern. In vivo, features of epithelial–mesenchymal transition have been associated with tumor budding, which correlates significantly with patient outcome. Hereby, the majority of tumor buds are not truly detached but still connected to a major tumor mass. For detailed insights into the different tumor bud types and the process of tumor budding, we quantified tumor cells according to histomorphological and immunohistological epithelial–mesenchymal transition characteristics. Three-dimensional reconstruction from adenocarcinomas (pancreatic, colorectal, lung, and ductal breast cancers) was performed as published. Tumor cell morphology and epithelial–mesenchymal transition characteristics (represented by zinc finger E-box-binding homeobox 1 and E-Cadherin) were analyzed qualitatively and quantitatively in a three-dimensional context. Tumor buds were classified into main tumor mass, connected tumor bud, and isolated tumor bud. Cell morphology and epithelial–mesenchymal transition marker expression were assessed for each tumor cell. Epithelial–mesenchymal transition characteristics between isolated tumor bud and connected tumor bud demonstrated no significant differences or trends. Tumor cell count correlated significantly with epithelial–mesenchymal transition and histomorphological characteristics. Regression curve analysis revealed initially a loss of membranous E-Cadherin, followed by expression of cytoplasmic E-Cadherin and subsequent expression of nuclear zinc finger E-box-binding homeobox 1. Morphologic changes followed later in this sequence. Our data demonstrate that connected and isolated tumor buds are equal concerning immunohistochemical epithelial–mesenchymal transition characteristics and histomorphology. Our data also give an insight in the process of tumor budding. While there is a notion that the epithelial–mesenchymal transition zinc finger E-box-binding homeobox 1–E-Cadherin cascade is initiated by zinc finger E-box-binding homeobox 1, our results are contrary and outline other possible pathways influencing the regulation of E-Cadherin.
    Type of Medium: Online Resource
    ISSN: 1010-4283 , 1423-0380
    URL: Article
    DOI: 10.1177/1010428317705501
    Language: English
    Publisher: IOS Press
    Publication Date: 2017
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    detail.hit.zdb_id: 1483579-4
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  • 3
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    A ground-based spectrometer equipped with an InGaAs array for routine observations of OH(3-1) rotational temperatures in the mesopause region
    Elsevier BV ; 2013
    In:  Journal of Atmospheric and Solar-Terrestrial Physics Vol. 102 ( 2013-09), p. 125-139
    Details
    In: Journal of Atmospheric and Solar-Terrestrial Physics, Elsevier BV, Vol. 102 ( 2013-09), p. 125-139
    Type of Medium: Online Resource
    ISSN: 1364-6826
    URL: Article
    DOI: 10.1016/j.jastp.2013.05.001
    RVK:
    UA 4547.8
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
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    SSG: 16,13
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  • 4
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    Spatiotemporal Variability of the Southern Annular Mode and its Influence on Antarctic Surface Temperatures
    American Geophysical Union (AGU) ; 2020
    In:  Journal of Geophysical Research: Atmospheres Vol. 125, No. 23 ( 2020-12-16)
    Details
    In: Journal of Geophysical Research: Atmospheres, American Geophysical Union (AGU), Vol. 125, No. 23 ( 2020-12-16)
    Abstract: We present a new approach to examine the spatiotemporal Southern Annular Mode pattern variability Station‐based Antarctic temperature anomalies are related to different structures of the Southern Annular Mode The trend pattern shows an increasing meridional structure and correlations with Pacific and Atlantic multidecadal oscillations
    Type of Medium: Online Resource
    ISSN: 2169-897X , 2169-8996
    URL: Article
    DOI: 10.1029/2020JD033818
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2020
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    detail.hit.zdb_id: 2016800-7
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    SSG: 16,13
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  • 5
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    Earth and space observation at the German Antarctic Receiving Station O’Higgins
    Cambridge University Press (CUP) ; 2015
    In:  Polar Record Vol. 51, No. 6 ( 2015-11), p. 590-610
    Details
    In: Polar Record, Cambridge University Press (CUP), Vol. 51, No. 6 ( 2015-11), p. 590-610
    Abstract: The German Antarctic Receiving Station (GARS) O’Higgins at the northern tip of the Antarctic Peninsula is a dual purpose facility for earth observation and has existed for more than 20 years. It serves as a satellite ground station for payload data downlink and telecommanding of remote sensing satellites as well as a geodetic observatory for global reference systems and global change. Both applications use the same 9 m diameter radio antenna. Major outcomes of this usage are summarised in this paper. The satellite ground station O’Higgins (OHG) is part of the global ground station network of the German Remote Sensing Data Centre (DFD) operated by the German Aerospace Centre (DLR). It was established in 1991 to provide remote sensing data downlink support within the missions of the European Remote Sensing Satellites ERS-1 and ERS-2. These missions provided valuable insights into the changes of the Antarctic ice shield. Especially after the failure of the on-board data recorder, OHG became an essential downlink station for ERS-2 real-time data transmission. Since 2010, OHG is manned during the entire year, specifically to support the TanDEM-X mission. OHG is a main dump station for payload data, monitoring and telecommanding of the German TerraSAR-X and TanDEM-X satellites. For space geodesy and astrometry the radio antenna O’Higgins significantly improves coverage over the southern hemisphere and plays an essential role within the global Very Long Baseline Interferometry (VLBI) network. In particular the determination of the Earth Orientation Parameters (EOP) and the sky coverage of the International Celestial Reference Frame (ICRF) benefit from the location at a high southern latitude. Further, the resolution of VLBI images of active galactic nuclei (AGN), cosmic radio sources defining the ICRF, improves significantly when O’Higgins is included in the network. The various geodetic instrumentation and the long time series at O’Higgins allow a reliable determination of crustal motions. VLBI station velocities, continuous GNSS measurements and campaign-wise absolute gravity measurements consistently document a vertical rate of about 5 mm/a. This crustal uplift is interpreted as an elastic rebound due to ice loss as a consequence of the ice shelf disintegration in the Prince Gustav Channel in the late 1990s. The outstanding location on the Antarctic continent and its year-around operation make GARS O’Higgins in future increasingly attractive for polar orbiting satellite missions and a vitally important station for the global VLBI network. Future plans call for the development of an observatory for environmentally relevant research. That means that the portfolio of the station will be expanded including the expansion of the infrastructure and the construction and operation of new scientific instruments suitable for long-term measurements and satellite ground truthing.
    Type of Medium: Online Resource
    ISSN: 0032-2474 , 1475-3057
    URL: Article
    DOI: 10.1017/S0032247414000540
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2015
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    detail.hit.zdb_id: 2100301-4
    SSG: 14
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  • 6
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    Bathymetric controls on calving processes at Pine Island Glacier
    Copernicus GmbH ; 2018
    In:  The Cryosphere Vol. 12, No. 6 ( 2018-06-15), p. 2039-2050
    Details
    In: The Cryosphere, Copernicus GmbH, Vol. 12, No. 6 ( 2018-06-15), p. 2039-2050
    Abstract: Abstract. Pine Island Glacier is the largest current Antarctic contributor to sea-level rise. Its ice loss has substantially increased over the last 25 years through thinning, acceleration and grounding line retreat. However, the calving line positions of the stabilising ice shelf did not show any trend within the observational record (last 70 years) until calving in 2015 led to unprecedented retreat and changed the alignment of the calving front. Bathymetric surveying revealed a ridge below the former ice shelf and two shallower highs to the north. Satellite imagery shows that ice contact on the ridge was likely lost in 2006 but was followed by intermittent contact resulting in back stress fluctuations on the ice shelf. Continuing ice-shelf flow also led to occasional ice-shelf contact with the northern bathymetric highs, which initiated rift formation that led to calving. The observations show that bathymetry is an important factor in initiating calving events.
    Type of Medium: Online Resource
    ISSN: 1994-0424
    URL: Article
    URL: Article
    DOI: 10.5194/tc-12-2039-2018
    DOI: 10.5194/tc-12-2039-2018-supplement
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2018
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  • 7
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    DataSheet_1.pdf
    Frontiers Media SA ; 2023
    In:  Frontiers in Endocrinology Vol. 14 ( 2023-1-30)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 14 ( 2023-1-30)
    Abstract: Klinefelter syndrome (KS) may be associated with a wide spectrum of phenotypic changes including endocrine, metabolic, cognitive, psychiatric and cardiorespiratory pathologies in adults. However, in adolescence the clinical phenotype of KS is not well described, especially regarding physical fitness. The present study reports on cardiorespiratory function in adolescents and young adults with KS. Methods Adolescents and young adults with KS were recruited in a cross-sectional pilot study. Biochemical parameters of fitness including hormonal status, a body impedance analysis, the grip strength, the amount of physical activity at home for 5 days via trackbands and anamnestic parameters were assessed. In addition, participants underwent an incremental symptom-limited cardiopulmonary exercise test (CPET) on a bicycle ergometer. Results Nineteen participants with KS aged 15.90 ± 4.12 years (range: 9.00 - 25.00) participated in the study. Pubertal status was Tanner 1 (n = 2), Tanner 2 - 4 (n = 7) and Tanner 5 (n = 10). Seven participants received testosterone replacement therapy. Mean BMI z-score was 0.45 ± 1.36 and mean fat mass was 22.93% ± 9.09. Grip strength was age-appropriate or above normal. 18 participants underwent CPET with subnormal results for maximum heart rate (z-score -2.84 ± 2.04); maximum workload (Watt max ; z score -1.28 ± 1.15) and maximum oxygen uptake per minute (z- score -2.25 ± 2.46). Eight participants (42.1%) met the criteria for chronotropic insufficiency (CI). Data from track-bands showed sedentary behavior for 81.15% ± 6.72 of the wear time. Conclusion A substantial impairment of cardiopulmonary function can be detected in this group of boys to young adults with KS, including chronotropic insufficiency in 40%. The track-band data suggest a predominantly sedentary lifestyle, despite normal muscular strength as assessed via grip strength. Future studies need to investigate the cardiorespiratory system and its adaption to physical stress in a larger cohort and in more detail. It is feasible that the observed impairments contribute to the avoidance of sports in individuals with KS and may contribute to the development of obesity and the unfavorable metabolic phenotype.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    URL: Article
    DOI: 10.3389/fendo.2023.1106118
    DOI: 10.3389/fendo.2023.1106118.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
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  • 8
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    Systemic sclerosis-associated myositis features minimal inflammation and characteristic capillary pathology
    Springer Science and Business Media LLC ; 2021
    In:  Acta Neuropathologica Vol. 141, No. 6 ( 2021-06), p. 917-927
    Details
    In: Acta Neuropathologica, Springer Science and Business Media LLC, Vol. 141, No. 6 ( 2021-06), p. 917-927
    Abstract: Systemic sclerosis represents a chronic connective tissue disease featuring fibrosis, vasculopathy and autoimmunity, affecting skin, multiple internal organs, and skeletal muscles. The vasculopathy is considered obliterative, but its pathogenesis is still poorly understood. This may partially be due to limitations of conventional transmission electron microscopy previously being conducted only in single patients. The aim of our study was therefore to precisely characterize immune inflammatory features and capillary morphology of systemic sclerosis patients suffering from muscle weakness. In this study, we identified 18 individuals who underwent muscle biopsy because of muscle weakness and myalgia in a cohort of 367 systemic sclerosis patients. We performed detailed conventional and immunohistochemical analysis and large-scale electron microscopy by digitizing entire sections for in-depth ultrastructural analysis. Muscle biopsies of 12 of these 18 patients (67%) presented minimal features of myositis but clear capillary alteration, which we termed minimal myositis with capillary pathology (MMCP). Our study provides novel findings in systemic sclerosis-associated myositis. First, we identified a characteristic and specific morphological pattern termed MMCP in 67% of the cases, while the other 33% feature alterations characteristic of other overlap syndromes. This is also reflected by a relatively homogeneous clinical picture among MMCP patients. They have milder disease with little muscle weakness and a low prevalence of interstitial lung disease (20%) and diffuse skin involvement (10%) and no cases of either pulmonary arterial hypertension or renal crisis. Second, large-scale electron microscopy, introducing a new level of precision in ultrastructural analysis, revealed a characteristic capillary morphology with basement membrane thickening and reduplications, endothelial activation and pericyte proliferation. We provide open-access pan-and-zoom analysis to our datasets, enabling critical discussion and data mining. We clearly highlight characteristic capillary pathology in skeletal muscles of systemic sclerosis patients.
    Type of Medium: Online Resource
    ISSN: 0001-6322 , 1432-0533
    URL: Article
    DOI: 10.1007/s00401-021-02305-3
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1458410-4
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  • 9
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    The degree of local inflammatory response after colonic resection depends on the surgical approach: an observational study in 61 patients
    Springer Science and Business Media LLC ; 2015
    In:  BMC Surgery Vol. 15, No. 1 ( 2015-12)
    Details
    In: BMC Surgery, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2015-12)
    Type of Medium: Online Resource
    ISSN: 1471-2482
    URL: Article
    DOI: 10.1186/s12893-015-0097-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2050442-1
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  • 10
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    SARS-CoV-2 sero-immunity and quality of life in children and adolescents in relation to infections and vaccinations: the IMMUNEBRIDGE KIDS cross-sectional study, 2022
    Springer Science and Business Media LLC ; 2023
    In:  Infection Vol. 51, No. 5 ( 2023-10), p. 1531-1539
    Details
    In: Infection, Springer Science and Business Media LLC, Vol. 51, No. 5 ( 2023-10), p. 1531-1539
    Abstract: The study evaluates the effects on sero-immunity, health status and quality of life of children and adolescents after the upsurge of the Omicron variant in Germany. Methods This multicenter cross-sectional study (IMMUNEBRIDGE Kids) was conducted within the German Network University Medicine (NUM) from July to October 2022. SARS-CoV-2- antibodies were measured and data on SARS-CoV-2 infections, vaccinations, health and socioeconomic factors as well as caregiver-reported evaluation on their children’s health and psychological status were assessed. Results 497 children aged 2–17 years were included. Three groups were analyzed: 183 pre-schoolchildren aged 2–4 years, 176 schoolchildren aged 5–11 years and 138 adolescents aged 12–18 years. Positive antibodies against the S- or N-antigen of SARS-CoV-2 were detected in 86.5% of all participants (70.0% [128/183] of pre-schoolchildren, 94.3% of schoolchildren [166/176] and 98.6% of adolescents [136/138]). Among all children, 40.4% (201/497) were vaccinated against COVID-19 (pre-schoolchildren 4.4% [8/183] , schoolchildren 44.3% [78/176] and adolescents 83.3% [115/138] ). SARS-CoV-2 seroprevalence was lowest in pre-school. Health status and quality of life reported by the parents were very positive at the time of the survey (Summer 2022). Conclusion Age-related differences on SARS-CoV-2 sero-immunity could mainly be explained by differences in vaccination rates based on the official German vaccination recommendations as well as differences in SARS-CoV-2 infection rates in the different age groups. Health status and quality of life of almost all children were very good independent of SARS-CoV-2 infection and/or vaccination. Trial registration German Registry for Clinical Trials Identifier Würzburg: DRKS00025546 (registration: 11.09.2021), Bochum: DRKS00022434 (registration:07.08.2020), Dresden: DRKS 00022455 (registration: 23.07.2020).
    Type of Medium: Online Resource
    ISSN: 0300-8126 , 1439-0973
    URL: Article
    DOI: 10.1007/s15010-023-02052-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2006315-5
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