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  • 1
    Online Resource
    Online Resource
    Determinants of Successful Aging Using a Multidimensional Definition Among Chinese Elderly in Singapore
    Elsevier BV ; 2009
    In:  The American Journal of Geriatric Psychiatry Vol. 17, No. 5 ( 2009-5), p. 407-416
    Details
    In: The American Journal of Geriatric Psychiatry, Elsevier BV, Vol. 17, No. 5 ( 2009-5), p. 407-416
    Type of Medium: Online Resource
    ISSN: 1064-7481
    URL: Article
    DOI: 10.1097/JGP.0b013e31819a808e
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2009
    detail.hit.zdb_id: 1474415-6
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  • 2
    Online Resource
    Online Resource
    Socio-Environmental, Lifestyle, Behavioural, and Psychological Determinants of Biological Ageing: The Singapore Longitudinal Ageing Study
    S. Karger AG ; 2020
    In:  Gerontology Vol. 66, No. 6 ( 2020), p. 603-613
    Details
    In: Gerontology, S. Karger AG, Vol. 66, No. 6 ( 2020), p. 603-613
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The identification of modifiable health span-promoting factors is a public health priority. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To explore the socio-environmental, lifestyle, behavioural, and psychological determinants of a clinical phenotypic measure of biological ageing in the Singapore Longitudinal Ageing Study (SLAS) cohort. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Using cross-sectional data on 2,844 SLAS-2 adults with a chronological age (CA) ≥55 years, we estimated biological age (BA) using a validated panel of clinical, biochemical, physiological, and functional indicators (8 in men and 10 in women) and calculated the difference between BA and CA (BA – CA in years). Potential determinants included education, housing status, loss of a spouse, living alone, lifestyle and health activity, smoking, alcohol consumption, nutritional risks, consumption of milk, soy, fruit, vegetables, coffee and tea, sleep parameters, and life satisfaction. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The mean CA was 67.0 (standard deviation [SD] 7.9; range 55–94) years. The estimated BA varied more widely (SD 8.9 years; range 47.5–119.9 years), and BA – CA ranged from –11.3 to 30.0 years. In stepwise selection regression analyses, multiple significant independent determinants in a final model were larger for private housing, being single/divorced/widowed, productivity, cognitive and leisure time activity scores, 10 h/week of moderate-to-vigorous physical activity, unintended loss of weight, life satisfaction, and daily consumption of fruits 1–2 or ≥3 servings and Chinese tea 1–2 or ≥3 cups daily, together explaining 16% of BA – CA variance in men and 14% in women. Associated BA – CA estimates were highest in men with high-end housing status (–1.8 years, effect size 0.015) and unintended weight loss (1.5 years, effect size 0.017). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 We identified determinants of biological ageing which can promote health span.
    Type of Medium: Online Resource
    ISSN: 0304-324X , 1423-0003
    URL: Article
    DOI: 10.1159/000511211
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1482689-6
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  • 3
    Online Resource
    Online Resource
    Life event stress and chronic obstructive pulmonary disease (COPD): associations with mental well-being and quality of life in a population-based study
    BMJ ; 2012
    In:  BMJ Open Vol. 2, No. 6 ( 2012), p. e001674-
    Details
    In: BMJ Open, BMJ, Vol. 2, No. 6 ( 2012), p. e001674-
    Type of Medium: Online Resource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    DOI: 10.1136/bmjopen-2012-001674
    Language: English
    Publisher: BMJ
    Publication Date: 2012
    detail.hit.zdb_id: 2599832-8
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  • 4
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    Online Resource
    The Elderly Nutritional Index for Geriatric Malnutrition Assessment (ENIGMA): concurrent, construct and predictive validity in an external evaluation cohort of community-dwelling older persons
    Cambridge University Press (CUP) ; 2022
    In:  British Journal of Nutrition Vol. 128, No. 3 ( 2022-08-14), p. 509-520
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 128, No. 3 ( 2022-08-14), p. 509-520
    Abstract: We previously developed a malnutrition risk index, the Elderly Nutritional Index for Geriatric Malnutrition Assessment (ENIGMA) with good predictive accuracy for mortality risk in an original population cohort (SLAS1). Herein, we further evaluate the concurrent and predictive validity of the ENIGMA construct in an external validation cohort (SLAS-2) of 2824 community-dwelling older adults aged 55+ years. They were assessed on the ENIGMA index, Mini Nutritional Assessment-Short Form (MNA-SF) and the Geriatric Nutritional Risk Index (GNRI), known correlates of malnutrition, and baseline and follow-up functional dependency and 10-year mortality risk. Higher ENIGMA risk categories were significantly associated ( P 〈 0·001) with lower education, living alone, smoking, low physical activity, BMI 〈 18·5 kg/m 2 , poorer muscle strength and functional mobility, exhaustion, physical frailty, homocysteine, glomerular filtration rate, Hb, red and white blood cell counts, platelets, systemic inflammation indexes, metabolic syndrome, CVD, cognitive impairment and depressive symptoms (Geriatric Depression Scale ≥ 5). ENIGMA scores showed statistically significant ( P 〈 0·001) correlations but low-to-moderate concordance with MNA-SF ( r = 0·148, agreement = 45·9 %, kappa = 0·085) and GNRI scores ( r = 0·156, agreement = 45·8 %, kappa = 0·096). Controlling for known correlates of malnutrition, only high-risk ENIGMA among the indexes significantly predicted baseline functional dependency (OR = 1·64, 95 % CI 1·01, 2·65) and mortality (hazard ratio = 1·65 (95 % CI 1·04, 2·62). ENIGMA marginally out-performed MNA-SF and GNRI in predicting baseline functional dependency (AUC: 0·625 v . 0·584 v . 0·526), follow-up functional dependency (AUC: 0·594 v . 0·525 v . 0·479) and 10-year mortality risk (AUC: 0·641 v . 0·596 v . 0·595). The concurrent and predictive validity of the ENIGMA construct is replicated in an external evaluation study of community-dwelling older persons.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1017/S0007114521003433
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2016047-1
    SSG: 12
    SSG: 21
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  • 5
    Online Resource
    Online Resource
    AI AND AGING: IDENTIFYING IMPORTANT LIVING ACTIVITIES FOR HEALTHY AGING IN SINGAPORE LONGITUDINAL AGING COHORT
    Oxford University Press (OUP) ; 2022
    In:  Innovation in Aging Vol. 6, No. Supplement_1 ( 2022-12-20), p. 743-743
    Details
    In: Innovation in Aging, Oxford University Press (OUP), Vol. 6, No. Supplement_1 ( 2022-12-20), p. 743-743
    Abstract: Population aging in Singapore has encouraged the development of ambient smart communities to support healthy aging. Poor understanding of the living activities that address both clinical and biological concerns may plague efficient aging service designs and community health programs. We have designed a new computational workflow to identify important living activities for older adults in Singapore. We investigated innovatively three pillars of human life aspects: activities, clinical health, and biological health to identify living activities that are significantly associated with both clinical health and biological health. Cross-sectional data analyses were performed on 1356 community-living Chinese older adults of 65–80 years old in the Singapore Longitudinal Aging Study II (SLASII) cohort. 7 out of 29 living activities were found significantly associated with clinically healthy aging and showed improved prediction accuracy towards health status in machining learning schemes. Furthermore, biological age has been computed by screening and modeling 66 biomarkers. 15 out of the 29 living activities were found significantly associated with biologically healthy aging. Checking the overlapping living activities, we have found that physical exercise and cognitive-simulating activities are the most important activities for healthy aging: such as jogging regularly and reading, writing, and doing puzzles often. We regroup participants into active and non-active groups according to these two activities. The Keplan-Meier survival analysis showed statistically significant differences in survival time between the active and non-active groups (p & lt; 0.001) in an 8-year longitudinal study. The workflow, results and biomarkers may provide references for future health program design improvement.
    Type of Medium: Online Resource
    ISSN: 2399-5300
    URL: Article
    DOI: 10.1093/geroni/igac059.2703
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2905697-4
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  • 6
    Online Resource
    Online Resource
    Association of Tai Chi exercise with physical and neurocognitive functions, frailty, quality of life and mortality in older adults: Singapore Longitudinal Ageing Study
    Oxford University Press (OUP) ; 2022
    In:  Age and Ageing Vol. 51, No. 4 ( 2022-04-01)
    Details
    In: Age and Ageing, Oxford University Press (OUP), Vol. 51, No. 4 ( 2022-04-01)
    Abstract: real-world observations on the long-term benefits of Tai Chi (TC) exercise, in terms of physical and cognitive functioning, frailty, quality of life (QOL) and mortality are lacking. Methods prospective cohort study participants were community-dwelling adults aged 55+, including 5,407 non-frequent TC participants ( & lt;1x/week) and 572 frequent TC participants (≥1x/week). Outcome measures at baseline and 3–5 years follow-up included physical performance (Knee Extension Strength, POMA Balance and Gait, Timed-up-and-go, Gait Speed) and neurocognitive performance (attention and working memory, visual-motor tracking and mental flexibility, verbal learning and memory, visual memory, spatial and constructional ability), Frailty Index ≥0.10, impaired QOL (SF12 physical and mental component) and all-cause mortality from mean 13 years follow-up. Effect estimates were adjusted for socio-demographics, other physical activities, nutritional risk and presence of cardiometabolic diseases. Results frequent TC participation was associated with 0.7-fold lower prevalence of impaired physical QOL [95% confidence interval (CI) = 0.57–0.91], decreased 0.4-fold odds of incident prefrailty/frailty among robust participants at baseline and 0.7-fold odds of impaired mental QOL at follow-up among participants with normal mental QOL at baseline. Lower odds of mortality risk (HR = 0.89, 95%CI = 0.72–1.09) were not significant after controlling for socioeconomic, behavioural and health factors. Composite indexes of physical functional and neurocognitive performance were maintained at high level or increased at follow-up among frequent TC participants. Conclusion TC exercise practised among community-dwelling older adults is associated with better physical, cognitive and functional wellbeing.
    Type of Medium: Online Resource
    ISSN: 0002-0729 , 1468-2834
    URL: Article
    DOI: 10.1093/ageing/afac086
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2065766-3
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  • 7
    Online Resource
    Online Resource
    Malnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study
    Informa UK Limited ; 2021
    In:  Clinical Interventions in Aging Vol. Volume 16 ( 2021-08), p. 1527-1539
    Details
    In: Clinical Interventions in Aging, Informa UK Limited, Vol. Volume 16 ( 2021-08), p. 1527-1539
    Type of Medium: Online Resource
    ISSN: 1178-1998
    URL: Article
    DOI: 10.2147/CIA.S322696
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2212420-2
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  • 8
    Online Resource
    Online Resource
    Malnutrition Risk and Kidney Function and Decline in Community-Dwelling Older Adults
    Elsevier BV ; 2022
    In:  Journal of Renal Nutrition Vol. 32, No. 5 ( 2022-09), p. 560-568
    Details
    In: Journal of Renal Nutrition, Elsevier BV, Vol. 32, No. 5 ( 2022-09), p. 560-568
    Type of Medium: Online Resource
    ISSN: 1051-2276
    URL: Article
    DOI: 10.1053/j.jrn.2021.09.002
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 9
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    Online Resource
    Functional health index of intrinsic capacity: multi-domain operationalisation and validation in the Singapore Longitudinal Ageing Study (SLAS2)
    Oxford University Press (OUP) ; 2022
    In:  Age and Ageing Vol. 51, No. 3 ( 2022-03-01)
    Details
    In: Age and Ageing, Oxford University Press (OUP), Vol. 51, No. 3 ( 2022-03-01)
    Abstract: ad hoc approaches are used to create composite indexes of intrinsic capacity (IC) based on five domains recommended by the World Health Organization for healthy ageing. We examined how combinations of domain-specific measures determine measurement performances of composite IC indexes. Methods in this population-based prospective cohort study, community-dwelling older persons (N = 2,906) aged 55 years and above were recruited. We used 12 domain-specific measures: cognition (Mini-Mental State Examination, MMSE), psychological (Geriatric Depression Scale, GDS), locomotion (Timed Up-and Go [TUG], GV, Knee Extension Strength, Performance Orientated Mobility Assessment), sensory (logarithm of the Minimum Angle of Resolution [LogMAR] vision and Whisper Test hearing) and vitality (forced expiratory volume in 1 second pulmonary function, Elderly Nutritional Indicators for Geriatric Malnutrition Assessment [ENIGMA], Nutritional Screening Initiative) to derive 144 composite 2- to 5-domain functional health indexes (FHI), and evaluated their abilities to predict 9-year mortality and their associations with health determinants. Results with 5-domain FHI, TUG, logMAR and MMSE showed the largest factor loadings (0.65–0.75). All single-domain FHI were significantly associated with mortality risks. Area under the receiver operating characteristic curve (AUC) values of mortality prediction increased with the number of domains (from mean 0.615 for single-domain FHI to mean 0.705 for 5-domain FHI), but the difference between 3-domain versus 4-domain FHI (P = 0.082) or versus 5-domain FHI (P = 0.109) was not statistically significant. Highest AUCs (P  & lt; 0.001) of best performing FHI were single-domain TUG: 0.735; 2-domain TUG + ENIGMA: 0.743; 3-domain TUG + LogMAR + ENIGMA: 0.762; 4-domain TUG + MMSE + LogMAR + ENIGMA: 0.757; 5-domain TUG + MMSE + GDS + LogMAR + ENIGMA: 0.751. FHI showed excellent construct validity based on correlations with known health determinants. Conclusions among Singaporean older adults, cognition, sensory and locomotion are predominant IC domains. A multi-domain IC index performs better with more domain measures, but a minimalist 3-domain index performs just as robustly as a 4- or 5-domain index.
    Type of Medium: Online Resource
    ISSN: 0002-0729 , 1468-2834
    URL: Article
    DOI: 10.1093/ageing/afac011
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2065766-3
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  • 10
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    Online Resource
    Neighborhood Makes or Breaks Active Ageing? Findings from Cross-Sectional Path Analysis
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 6 ( 2022-03-20), p. 3695-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 6 ( 2022-03-20), p. 3695-
    Abstract: Mental ill-health prolongs and complicates other chronic illnesses, which is a major public health concern because of the potential stress it places on health systems. Prevention via active aging and place-based interventions thus became increasingly important with population aging, e.g., through health promotion and age-friendly neighborhoods. However, how the targeted outcomes of these efforts are related remains unclear. This paper examined whether the relationship between active living and mental health or health-related quality of life is mediated by neighborhood cohesion. Cross-sectional data were drawn from n = 270 community-dwelling adults aged 50 and above in the Gerontology Research Program—Center for Ageing Research in the Environment (GRP-CARE) Survey. Path analysis showed that one can live actively for better mental health (Btotal = 0.24), but it is largely mediated by neighborhood cohesion (37%). Further examination of the factors of neighborhood cohesion showed that this mediation is explained by communal affordance (Bindirect = 0.05) and neighborhood friendship (Bindirect = 0.05). Additional study of the association between these mediators and factors of mental health revealed two psychosocial processes: (1) better community spaces (e.g., greenery and third places) support communal living (B = 0.36) and help older adults obtain emotional support (B = 0.32) for greater autonomy (B = 0.25); (2) spending more time outdoors enhances neighborhood friendship (B = 0.33) and interpersonal skills (B = 0.37), which in turn improves coping (B = 0.39). In short, the effects of active living on health are limited by one’s neighborhood environment. Neighborhood cohesion must be considered or it may stifle individual and policy efforts to age actively and healthily in urban environments. Context-sensitive implementations are required.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph19063695
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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