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  • 1
    Online Resource
    Online Resource
    Non-Invasive Differential Diagnosis of Cervical Neoplastic Lesions by the Lipid Profile Analysis of Cervical Scrapings
    MDPI AG ; 2022
    In:  Metabolites Vol. 12, No. 9 ( 2022-09-19), p. 883-
    Details
    In: Metabolites, MDPI AG, Vol. 12, No. 9 ( 2022-09-19), p. 883-
    Abstract: Cervical cancer is one of the most common cancers in women with pronounced stages of precancerous lesions. Accurate differential diagnosis of such lesions is one of the primary challenges of medical specialists, which is vital to improving patient survival. The aim of this study was to develop and test an algorithm for the differential diagnosis of cervical lesions based on lipid levels in scrapings from the cervical epithelium and cervicovaginal canal. The lipid composition of the samples was analyzed by high-performance chromato-mass spectrometry. Lipid markers were selected using the Mann–Whitney test with a cutoff value of 0.05 and by projections to latent structures discriminant analysis, where a projection threshold of one was chosen. The final selection of variables for binomial logistic regressions was carried out using the Akaike information criterion. As a result, a final neoplasia classification method, based on 20 logistic regression sub-models, has an accuracy of 79% for discrimination NILM/cervicitis/LSIL/HSIL/cancer. The model has a sensitivity of 83% and a specificity of 88% for discrimination of several lesions (HSIL and cancer). This allows us to discuss the prospective viability of further validation of the developed non-invasive method of differential diagnosis.
    Type of Medium: Online Resource
    ISSN: 2218-1989
    URL: Article
    DOI: 10.3390/metabo12090883
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662251-8
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  • 2
    Online Resource
    Online Resource
    Nonanalytic Relativistic r-Modes of Slowly Rotating Nonbarotropic Neutron Stars
    MDPI AG ; 2022
    In:  Universe Vol. 8, No. 10 ( 2022-10-19), p. 542-
    Details
    In: Universe, MDPI AG, Vol. 8, No. 10 ( 2022-10-19), p. 542-
    Abstract: We show that the r-modes of slowly rotating nonbarotropic neutron stars are described by nonanalytic functions of stellar angular velocity, which makes the perturbation techniques, used so far in the r-mode theoretical studies, inapplicable. In contrast to those studies and in accordance with numerical calculations beyond the slow rotation approximation, the obtained r-mode spectrum is discrete, which resolves the continuous spectrum problem, lasting since 1997. Our findings imply that the relativistic r-modes in slowly rotating neutron stars dramatically differ from their Newtonian cousins, which may have important implications for the detectability of r-mode signatures in observations, in particular for the r-mode excitation efficiency during the neutron star inspirals.
    Type of Medium: Online Resource
    ISSN: 2218-1997
    URL: Article
    DOI: 10.3390/universe8100542
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2813994-X
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  • 3
    Online Resource
    Online Resource
    Diffusion as a damping mechanism for neutron-star oscillations
    IOP Publishing ; 2020
    In:  Journal of Physics: Conference Series Vol. 1697, No. 1 ( 2020-12-01), p. 012023-
    Details
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 1697, No. 1 ( 2020-12-01), p. 012023-
    Abstract: We study the effects of diffusion on damping of oscillations in the neutron star cores. This dissipation mechanism is usually ignored in the literature. As we show, the effect of diffusion is always smaller than viscous dissipation if the normal (nonsuperfluid and nonsuperconducting) matter of neutron stars is considered. However, we argue that for superconducting stars the role of diffusion may increase.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    URL: Article
    DOI: 10.1088/1742-6596/1697/1/012023
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 2166409-2
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  • 4
    Online Resource
    Online Resource
    Vaccination as an effective method of prevention for cervical diseases associated with human papillomavirus (literature review)
    Consilium Medicum ; 2019
    In:  Gynecology Vol. 21, No. 2 ( 2019-04-15), p. 23-27
    Details
    In: Gynecology, Consilium Medicum, Vol. 21, No. 2 ( 2019-04-15), p. 23-27
    Abstract: The role of human papillomavirus (HPV) in the development of cervical cancer and other diseases of the anogenital area has been proven and well known. Despite this, the incidence of cervical cancer is growing every year. Specific methods of HPV treatment are not developed, and the only effective method of cervical cancer prevention is to prevent infection itself. A number of randomized clinical trials have demonstrated extremely high (up to 100%) effectiveness of HPV vaccines. Currently, the HPV vaccine is approved by WHO and included in the National Immunization Program of 86 countries, 17 counties use gender-neutral program. In the clinical practice of Australia, USA and countries of the European Union, in particular Italy, Germany and France, high efficiency of vaccination for 10 or more years is reported.
    Type of Medium: Online Resource
    ISSN: 2079-5831 , 2079-5696
    URL: Article
    DOI: 10.26442/20795696.2019.2.190396
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2019
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