In:
Gastroenterology Research and Practice, Hindawi Limited, Vol. 2020 ( 2020-08-29), p. 1-7
Kurzfassung:
The aim of this study is to evaluate the association between seven important H . pylori virulence factors and antibiotic resistance in patients with gastritis. H . pylori strains isolated from 33 patients with gastritis were examined. Antimicrobial susceptibilities were tested by GenoType® HelicoDR (Hain Life Science, Germany) test kit and RT-PCR. The virulence-factors were determined using conventional PCR. 39% of patients were resistant for clarithromycin and 27% of patients were resistant for fluoroquinolone. 15% of patients were resistant to both clarithromycin and fluoroquinolone. The H . pylori vacA m1/s2 genotype was the most frequent allelic combination. Patients were possessed the vacA s1 , m1 (6.1%); s1 , m2 (6.1%); s2 , m1 (15.1%); and s2 , m2 (3.0%) genotypes. 94% of patients with gastritis were positive for H . pylori napA gene. Also, there were no dupA gene-positive gastritis patients. There was no significant correlation between the vacA , cagA , oipA , hpaA , babA , napA , dupA , ureA , ureB virulence genes, clarithromycin, and fluoroquinolone resistance. Herein, we report that the relationship between the H . pylori napA gene and gastritis. Although we found a correlation between H . pylori virulence factor and clinical outcome, there is a need for further studies to enlighten the relation between H . pylori virulence genes and antibiotic resistance.
Materialart:
Online-Ressource
ISSN:
1687-6121
,
1687-630X
DOI:
10.1155/2020/3956838
Sprache:
Englisch
Verlag:
Hindawi Limited
Publikationsdatum:
2020
ZDB Id:
2435460-0
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