In:
Journal of Applied Toxicology, Wiley, Vol. 34, No. 3 ( 2014-03), p. 241-249
Abstract:
Effects of AFB 1 on splenic lymphocyte phenotypes and cytokine expression were investigated in male F344 rats. Single‐dose exposure to AFB 1 decreased expression of CD8 + T cells and CD3 − CD8a + NK cells. Expressions of IL‐4 and IFN‐γ by CD4 + T cells, IL‐4 and IFN‐γ by CD8a + cells, and TNF‐α by NK cells were also inhibited; Repeated AFB 1 exposure significantly decreased expression of IL‐4 by CD4 + T cells and significantly increased expressions of pro‐IFN‐γ by CD4 + T cells and TNF‐α by NK cells.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1475015-6
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