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  • 1
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    Online Resource
    High prevalence and risk factors of multiple antibiotic resistance in patients who fail first-line Helicobacter pylori therapy in southern China: a municipality-wide, multicentre, prospective cohort study
    Oxford University Press (OUP) ; 2020
    In:  Journal of Antimicrobial Chemotherapy Vol. 75, No. 11 ( 2020-11-01), p. 3391-3394
    Details
    In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 75, No. 11 ( 2020-11-01), p. 3391-3394
    Abstract: We aimed to study the prevalence of secondary antibiotic resistance of Helicobacter pylori in southern China and its risk factors, particularly geographical and socio-economic factors. Methods This was a municipality-wide, multicentre, prospective cohort study involving five major hospitals. Patients aged ≥18 years who failed first-line bismuth-based quadruple anti-H. pylori therapy between September 2016 and February 2018 were recruited. Participants underwent upper gastrointestinal endoscopy with biopsy from the antrum and body for H. pylori culture and antimicrobial susceptibility testing for six antibiotics (clarithromycin, levofloxacin, metronidazole, amoxicillin, tetracycline and furazolidone). Patients with failure of H. pylori culture were excluded. Participants completed a questionnaire profiling 22 potential risk factors of H. pylori infection and antibiotic resistance, including medical, social, household and birthplace factors. Results A total of 1113 patients failed first-line therapy, with successful H. pylori culture in 791 (71.1%) [male = 433 (54.7%); median age = 43 years]. Secondary resistance rates of dual antibiotics (clarithromycin + metronidazole and levofloxacin + metronidazole) and triple antibiotics (clarithromycin + levofloxacin + metronidazole) were 34.0%, 38.7% and 17.8%, respectively. Risk factors for clarithromycin + metronidazole resistance were history of ≥2 courses of H. pylori therapies [adjusted OR (aOR) = 1.71; 95% CI = 1.17–2.54] , ≥3 household members (aOR = 2.00; 95% CI = 1.07–3.90) and family history of gastric cancer (aOR = 1.85; 95% CI = 1.18–2.85). Risk factors for levofloxacin + metronidazole resistance were age ≥40 years (aOR = 1.94; 95% CI = 1.37–2.75), lower gross domestic product per capita (aOR = 0.29; 95% CI = 0.10–0.80) and higher number of doctors/10 000 population (aOR = 1.59; 95% CI = 1.07–2.39). A higher human development index was of borderline significance (aOR = 2.79; 95% CI = 0.97–8.70). Conclusions The rates of secondary resistance of H. pylori to multiple antibiotics were high in southern China. Certain population-level risk factors were associated with levofloxacin + metronidazole resistance.
    Type of Medium: Online Resource
    ISSN: 0305-7453 , 1460-2091
    URL: Article
    DOI: 10.1093/jac/dkaa315
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1467478-6
    SSG: 15,3
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  • 2
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    The microstructure evolution and nucleation mechanisms of dynamic recrystallization in hot-deformed Inconel 625 superalloy
    Elsevier BV ; 2011
    In:  Materials & Design Vol. 32, No. 2 ( 2011-2), p. 696-705
    Details
    In: Materials & Design, Elsevier BV, Vol. 32, No. 2 ( 2011-2), p. 696-705
    Type of Medium: Online Resource
    ISSN: 0261-3069
    URL: Article
    DOI: 10.1016/j.matdes.2010.07.040
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 2015480-X
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  • 3
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    The effect of deformation temperature on the microstructure evolution of Inconel 625 superalloy
    Elsevier BV ; 2011
    In:  Journal of Nuclear Materials Vol. 414, No. 3 ( 2011-7), p. 440-450
    Details
    In: Journal of Nuclear Materials, Elsevier BV, Vol. 414, No. 3 ( 2011-7), p. 440-450
    Type of Medium: Online Resource
    ISSN: 0022-3115
    URL: Article
    DOI: 10.1016/j.jnucmat.2011.05.029
    RVK:
    UQ 7360
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 2001279-2
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  • 4
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    Effect of Deformation Conditions on the Dynamic Recrystallization of GH690 Alloy
    Elsevier BV ; 2012
    In:  Rare Metal Materials and Engineering Vol. 41, No. 8 ( 2012-8), p. 1317-1322
    Details
    In: Rare Metal Materials and Engineering, Elsevier BV, Vol. 41, No. 8 ( 2012-8), p. 1317-1322
    Type of Medium: Online Resource
    ISSN: 1875-5372
    URL: Article
    DOI: 10.1016/S1875-5372(12)60061-7
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
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  • 5
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    Super Dominant Pathobiontic Bacteria in the Nasopharyngeal Microbiota Cause Secondary Bacterial Infection in COVID-19 Patients
    American Society for Microbiology ; 2022
    In:  Microbiology Spectrum Vol. 10, No. 3 ( 2022-06-29)
    Details
    In: Microbiology Spectrum, American Society for Microbiology, Vol. 10, No. 3 ( 2022-06-29)
    Abstract: Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease responsible for many infections worldwide. Differences in respiratory microbiota may correlate with disease severity. Samples were collected from 20 severe and 51 mild COVID-19 patients. High-throughput sequencing of the 16S rRNA gene was used to analyze the bacterial community composition of the upper and lower respiratory tracts. The indices of diversity were analyzed. When one genus accounted for 〉 50% of reads from a sample, it was defined as a super dominant pathobiontic bacterial genus (SDPG). In the upper respiratory tract, uniformity indices were significantly higher in the mild group than in the severe group ( P 〈 0.001). In the lower respiratory tract, uniformity indices, richness indices, and the abundance-based coverage estimator were significantly higher in the mild group than in the severe group ( P 〈 0.001). In patients with severe COVID-19, SDPGs were detected in 40.7% of upper and 63.2% of lower respiratory tract samples. In patients with mild COVID-19, only 10.8% of upper and 8.5% of lower respiratory tract samples yielded SDPGs. SDPGs were present in both upper and lower tracts in seven patients (35.0%), among which six (30.0%) patients possessed the same SDPG in the upper and lower tracts. However, no patients with mild infections had an SDPG in both tracts. Staphylococcus , Corynebacterium , and Acinetobacter were the main SDPGs. The number of SDPGs identified differed significantly between patients with mild and severe COVID-19 ( P 〈 0.001). SDPGs in nasopharyngeal microbiota cause secondary bacterial infection in COVID-19 patients and aggravate pneumonia. IMPORTANCE The nasopharyngeal microbiota is composed of a variety of not only the true commensal bacterial species but also the two-face pathobionts, which are one a harmless commensal bacterial species and the other a highly invasive and deadly pathogen. In a previous study, we found that the diversity of nasopharyngeal microbiota was lost in severe influenza patients. We named the genus that accounted for over 50% of microbiota abundance as super dominant pathobiontic genus, which could invade to cause severe pneumonia, leading to high fatality. Similar phenomena were found here for SARS-CoV-2 infection. The diversity of nasopharyngeal microbiota was lost in severe COVID-19 infection patients. SDPGs in nasopharyngeal microbiota were frequently detected in severe COVID-19 patients. Therefore, the SDPGs in nasopharynx microbiota might invade into low respiratory and be responsible for secondary bacterial pneumonia in patients with SARS-CoV-2 infection.
    Type of Medium: Online Resource
    ISSN: 2165-0497
    URL: Article
    DOI: 10.1128/spectrum.01956-21
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2022
    detail.hit.zdb_id: 2807133-5
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  • 6
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    Nucleation mechanisms of dynamic recrystallization in Inconel 625 superalloy deformed with different strain rates
    Springer Science and Business Media LLC ; 2012
    In:  Rare Metals Vol. 31, No. 3 ( 2012-6), p. 215-220
    Details
    In: Rare Metals, Springer Science and Business Media LLC, Vol. 31, No. 3 ( 2012-6), p. 215-220
    Type of Medium: Online Resource
    ISSN: 1001-0521 , 1867-7185
    URL: Article
    DOI: 10.1007/s12598-012-0494-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
    detail.hit.zdb_id: 2238702-X
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  • 7
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    Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis
    BMJ ; 2023
    In:  Gut Vol. 72, No. 9 ( 2023-09), p. 1664-1677
    Details
    In: Gut, BMJ, Vol. 72, No. 9 ( 2023-09), p. 1664-1677
    Abstract: Gut microbiota dysbiosis is closely linked to the pathogenesis of rheumatoid arthritis (RA). We aimed to identify potential probiotic gut microbes that can ameliorate the development of RA. Design Microbiota profiling in patients with RA and healthy individuals was investigated via 16S rDNA bacterial gene sequencing and shotgun metagenomics. Collagen-induced arthritic mice and TNF-α transgenic mice were used to evaluate the roles of the gut commensal Parabacteroides distasonis in RA. The effects of P. distasonis -derived microbial metabolites on the differentiation of CD4 + T cells and macrophage polarisation were also investigated. Results The relative abundance of P. distasonis in new-onset patients with RA and patients with RA with history of the disease was downregulated and this decrease was negatively correlated with Disease Activity Score-28 (DAS28). Oral treatment of arthritic mice with live P. distasonis (LPD) considerably ameliorated RA pathogenesis. LPD-derived lithocholic acid (LCA), deoxycholic acid (DCA), isolithocholic acid (isoLCA) and 3-oxolithocholic acid (3-oxoLCA) had similar and synergistic effects on the treatment of RA. In addition to directly inhibiting the differentiation of Th17 cells, 3-oxoLCA and isoLCA were identified as TGR5 agonists that promoted the M2 polarisation of macrophages. A specific synthetic inhibitor of bile salt hydrolase attenuated the antiarthritic effects of LPD by reducing the production of these four bile acids. The natural product ginsenoside Rg2 exhibited its anti-RA effects by promoting the growth of P. distasonis . Conclusions P. distasonis and ginsenoside Rg2 might represent probiotic and prebiotic agents in the treatment of RA.
    Type of Medium: Online Resource
    ISSN: 0017-5749 , 1468-3288
    URL: Article
    DOI: 10.1136/gutjnl-2022-327756
    RVK:
    XA 10000
    Language: English
    Publisher: BMJ
    Publication Date: 2023
    detail.hit.zdb_id: 1492637-4
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  • 8
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    Investigation on hot workability characteristics of Inconel 625 superalloy using processing maps
    Springer Science and Business Media LLC ; 2012
    In:  Journal of Materials Science Vol. 47, No. 15 ( 2012-8), p. 5867-5878
    Details
    In: Journal of Materials Science, Springer Science and Business Media LLC, Vol. 47, No. 15 ( 2012-8), p. 5867-5878
    Type of Medium: Online Resource
    ISSN: 0022-2461 , 1573-4803
    URL: Article
    DOI: 10.1007/s10853-012-6488-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
    detail.hit.zdb_id: 2015305-3
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  • 9
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    Effect of Wetting-Drying Cycle on the Deformation and Seepage Behaviors of Rock Masses around a Tunnel
    Hindawi Limited ; 2020
    In:  Geofluids Vol. 2020 ( 2020-05-26), p. 1-14
    Details
    In: Geofluids, Hindawi Limited, Vol. 2020 ( 2020-05-26), p. 1-14
    Abstract: Water inrush caused by the wetting-drying cycle is a difficult problem in tunnel excavation. To investigate the effect of the wetting-drying cycle on the stability of the tunnel surrounding rock, physical experiments and numerical simulations regarding the process of tunnel excavation with different wetting-drying cycle numbers were performed in this study. The evolutions of stress, displacement, and pore water pressure were analyzed. With the increase in cycle number, the pore water pressure, vertical stress, and top-bottom approach of the tunnel surrounding rock increase gradually. And the increasing process could be divided into three stages: slightly increasing stage, slowly increasing stage, and sharply increasing stage, respectively. The failure process of the surrounding rock under the wetting-drying cycle gradually occurs from the roof to side wall, while the baseplate changes slightly. The simulation results showed that the maximum principal stress in the surrounding rock mass of the tunnel increases, while the minimum principal stress decreases. Furthermore, the displacement of the rock mass decreases gradually with the increasing distance from the tunnel surface. By comparing the simulation results with the experimental results, well consistency is shown. The results in this study can provide helpful references for the safe excavation and scientific design of a tunnel under the wetting-drying cycle.
    Type of Medium: Online Resource
    ISSN: 1468-8115 , 1468-8123
    URL: Article
    DOI: 10.1155/2020/4237163
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 10
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    Evaluation of serum alkaline phosphatase measurement through the 4-year trueness verification program in China
    Walter de Gruyter GmbH ; 2018
    In:  Clinical Chemistry and Laboratory Medicine (CCLM) Vol. 56, No. 12 ( 2018-11-27), p. 2072-2078
    Details
    In: Clinical Chemistry and Laboratory Medicine (CCLM), Walter de Gruyter GmbH, Vol. 56, No. 12 ( 2018-11-27), p. 2072-2078
    Abstract: Alkaline phosphatase (ALP) is critical for various diseases. The International Federation of Clinical Chemistry and Laboratory Medicine had recommended the new reference procedure in 2011, but many manufacturers did not trace results to the higher procedure. Since 2012, the National Center for Clinical Laboratories (NCCL) in China has organized the trueness verification program (TV) with commutable materials. The present study summarizes the 4-year TV program to give an overview of the measurement standardization for ALP results. Methods Commutable serum-based materials with different concentrations were prepared and sent to participating laboratories. The target values were assigned by the reference lab network. Results The analytical performance was evaluated according to three indexes: trueness (bias), imprecision (CV) and accuracy (total error [TE]). The number of participating laboratories increased from 115 in 2012 to 287 in 2016. The pass rates of precision for homogeneous and heterogeneous systems were all above 85% over the 4 years; however, the pass rates of bias were much lower ( 〈 50%). Among the homogeneous systems, Roche Cobas/Modular had an obvious negative bias, whereas the mean positive bias for Beckman AU was prominent. As to the heterogeneous systems, the pass rates of bias for Sichuan Maccura (57.1%–78.6%) were higher than Roche Cobas/Modular (4.4%–33.9%) and Beckman AU (35.7%–64.8%). Conclusions The PT/EQA program with commutable materials can be used to assess the trueness against target values assigned by reference procedures. For ALP, homogeneous systems did not perform better than heterogeneous systems. The bias for ALP performance was notable and was the main obstacle to its standardization in China.
    Type of Medium: Online Resource
    ISSN: 1437-4331 , 1434-6621
    URL: Article
    DOI: 10.1515/cclm-2018-0399
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2018
    detail.hit.zdb_id: 1492732-9
    SSG: 15,3
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