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  • 1
    In: The Journal of Critical Care Medicine, Walter de Gruyter GmbH, Vol. 8, No. 4 ( 2022-11-12), p. 259-265
    Abstract: The RECOVERY study documented lower 28-day mortality with the use of dexamethasone in hospitalized patients on invasive mechanical ventilation or oxygen with COVID-19 Pneumonia. We aimed to examine the practice patterns of steroids use, and their impact on mortality and length of stay in ICU. We retrospectively examined records of all patients with confirmed Covid 19 pneumonia admitted to the ICU of Dubai hospital from January 1st, 2020 – June 30th, 2020. We assigned patients to four groups (No steroids, low dose, medium dose, and high dose steroids). The primary clinical variable of interest was doses of steroids. Secondary outcomes were 28-day mortality and length of stay in ICU”. We found variability in doses of steroid treatment. The most frequently used dose was the high dose. Patients who survived were on significantly higher doses of steroids and had significantly longer stays in ICU. The prescription of steroids in Covid-19 ARDS is variable. The dose of steroids impacts mortality rate and length of stay in ICU, although patients treated with high dose steroids seem to stay more days in ICU.
    Type of Medium: Online Resource
    ISSN: 2393-1817
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2022
    detail.hit.zdb_id: 2861891-9
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  • 2
    In: Dubai Medical Journal, S. Karger AG, Vol. 4, No. 2 ( 2021-4-14), p. 151-155
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Coronavirus has caused more than a million deaths as of October 2020. Hospitals consider tracheostomy after the patient is virus negative, usually after 3 weeks. Prevalence and timing of tracheostomy and its impact on survival among COVID patients are unknown. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A retrospective, single-center study of all patients with COVID-19 ARDS who underwent tracheostomy was conducted. Patients with age & #x3c;18 and patients treated with ECMO were excluded. Duration of ventilation before tracheostomy was recorded. Clinical variables, outcome variables, and confounding variables were recorded and compared between patients with tracheostomy and without tracheostomy. The aim was to determine prevalence and timing of tracheostomy and its impact on clinical outcomes. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 We found that tracheostomies were performed only in 21 out of 196 patients (10.8%). Tracheostomies were performed after 3 weeks on average (22.1 ± 7.5 days). Survival was significantly higher in patients who underwent tracheostomy (85.7 vs. 42.5%, 〈 i 〉 p 〈 /i 〉 = 0.001). LOSICU was longer for tracheostomy patients than patients without tracheostomy (median [IQR]: 35 [23–47] vs. 15 [9–21], 〈 i 〉 p 〈 /i 〉 = 0.001). Patients who underwent tracheostomy had a higher proportion of treatment with continuous renal replacement therapy (CRRT) (52 vs. 30%, 〈 i 〉 p 〈 /i 〉 = 0.04), more COVID-19 swab testing (6.5 [4.5–8.5] vs. 5 [3–7] , 〈 i 〉 p 〈 /i 〉 = 0.002), more days on mechanical ventilation (34.5 [24–45] vs. 11 [5.5–16.5] , 〈 i 〉 p 〈 /i 〉 = 0.001), and more length of stay in the hospital (54 [38–70] vs. 20 [10.5–29.5] , 〈 i 〉 p 〈 /i 〉 = 0.001). All other factors were not statistically different between the 2 groups. Approximately 29% of patients had possible false-negative testing as their swab became positive after being negative. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Tracheostomy was performed only in 10% of our patients with COVID-19 ARDS. Time to tracheostomy was after 3 weeks on average. Survival was better in patients with tracheostomy, but tracheostomized patients stayed longer in the ICU and hospital and utilized more days of mechanical ventilation and CRRT.
    Type of Medium: Online Resource
    ISSN: 2571-726X
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 2938789-9
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  • 3
    Online Resource
    Online Resource
    Universidad Tecnica de Manabi ; 2022
    In:  International journal of health sciences ( 2022-06-30), p. 5462-5475
    In: International journal of health sciences, Universidad Tecnica de Manabi, ( 2022-06-30), p. 5462-5475
    Abstract: Type 2 Diabetes mellitus (Type 2DM) is chronic, lifelong progressive metabolic disease characterized by hyperglycaemia due to absolute or relative insulinopaenia. The metabolic dysregulation that contributes to hyperglycaemia includes diminished insulin secretion, impaired glucose utilization or increased glucose production, and eventually causes pathophysiological changes in multiple organs and organ systems. Our study showed Sitagliptin was superior in reducing HOMA-IR when compared with metformin. If combination of Sitagliptin and metformin is used far superior reduction will be achieved on HOMA- IR. Limitation of our study was short duration of study and small sample size.
    Type of Medium: Online Resource
    ISSN: 2550-696X , 2550-6978
    URL: Issue
    Language: Unknown
    Publisher: Universidad Tecnica de Manabi
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Universidad Tecnica de Manabi ; 2022
    In:  International journal of health sciences ( 2022-08-08), p. 7459-7469
    In: International journal of health sciences, Universidad Tecnica de Manabi, ( 2022-08-08), p. 7459-7469
    Abstract: Tablet dosage form is the most popular among all existing conventional dosage forms because of its convenience of self-administration, compactness and easy manufacturing. Many patients find it difficult to swallow tablets and capsules. The difficulty is experienced in particular by pediatric and geriatric patients, but it also applies to people who are ill on bed and to those active working patients who are busy or traveling, especially those who have no access to water. The drug hydralazine HCl were used. The amount of drug was 35 mg. the different super disintegrates was used to make a suitable mouth dissolving tablet. All the other reagents which is used in analytical grade reagents. In the present study mouth dissolving tablets of hydralazine HCl were designed, prepared and evaluated. These tablets can disintegrate or dissolve rapidly once placed into the oral cavity. The feofenadine was analyzed for its organoleptic, physicochemical and spectral (IR, UV) properties. The obtained hydralazine HCl was concordant with reference specifications. A complex of hydralazine HCl was successfully formulated. The volunteers rated the resinate as tasteless and agreeable complex.
    Type of Medium: Online Resource
    ISSN: 2550-696X , 2550-6978
    URL: Issue
    Language: Unknown
    Publisher: Universidad Tecnica de Manabi
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Ninety Nine Publication ; 2018
    In:  Journal of Advance Research in Medical & Health Science (ISSN: 2208-2425) Vol. 4, No. 3 ( 2018-03-31), p. 01-12
    In: Journal of Advance Research in Medical & Health Science (ISSN: 2208-2425), Ninety Nine Publication, Vol. 4, No. 3 ( 2018-03-31), p. 01-12
    Abstract:  Platelet rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors and cells are trapped and may be released after a certain time and that can serve as a resorbable membrane. In the present review article, the evolution, preparation of PRF has been described. Autologous PRF is considered to be a healing biomaterial, which has its numerous applications in various disciplines of dentistry.
    Type of Medium: Online Resource
    ISSN: 2208-2425
    Language: Unknown
    Publisher: Ninety Nine Publication
    Publication Date: 2018
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  • 6
    Online Resource
    Online Resource
    Universidad Tecnica de Manabi ; 2022
    In:  International journal of health sciences ( 2022-06-23), p. 3630-3640
    In: International journal of health sciences, Universidad Tecnica de Manabi, ( 2022-06-23), p. 3630-3640
    Abstract: Wafers are modern oral dosage forms which are commonly used by patients worldwide. Also, in acute pain, these dosage types can be used to get immediate relief.  These oral sublingual wafers are nothing more than a thin oral stripe which dissolves immediately due to the presence of saliva in the mouth when placed in the sublingual cavity by releasing medication within a short span of time. The faster dissolution can be achieved by using different superdisintegrants in different concentrations and a comparative study of different superdisintegrants has been carried out. Present investigation aims to formulate fast dissolving wafer of linagliptin using different film forming agents. From the latest research it can be inferred that fast-dissolving oral films of drug release are preferable. The films prepared by HPMC K4 and K15 and CCS and CP had shown strong mechanical power, release of narcotics, period for disintegration and analysis of dissolution. F7 formulation is considered the better with less disintegrating time and release in 10 min according to the results obtained. Percent drug release and disintegration time was taken as responses for study which were found within the accepted ranges.
    Type of Medium: Online Resource
    ISSN: 2550-696X , 2550-6978
    URL: Issue
    Language: Unknown
    Publisher: Universidad Tecnica de Manabi
    Publication Date: 2022
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