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  • 1
    Online Resource
    Online Resource
    Keep S’Myelin: World Brain Day 2021 Editorial for Residents and Junior Doctors Page—Neurology International MDPI
    MDPI AG ; 2021
    In:  Neurology International Vol. 13, No. 3 ( 2021-08-12), p. 402-403
    Details
    In: Neurology International, MDPI AG, Vol. 13, No. 3 ( 2021-08-12), p. 402-403
    Abstract: Every five minutes someone in the world is diagnosed with multiple sclerosis [...]
    Type of Medium: Online Resource
    ISSN: 2035-8377
    URL: Article
    DOI: 10.3390/neurolint13030039
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2514727-4
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  • 2
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    Abstract WP30: Delay and Dispersion Correction Leads to More Accurate Core Estimation for Endovascular Thrombectomy Patients
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Stroke Vol. 51, No. Suppl_1 ( 2020-02)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 51, No. Suppl_1 ( 2020-02)
    Abstract: Objective: Endovascular thrombectomy (EVT) significantly improves clinical outcomes in acute ischemic stroke with large vessel occlusion. Clinical benefits are inversely proportional to size of the pre-treatment ischemic core. Therefore, accurate measurement of the size of core is critical in selecting patients for EVT. Different post-processing perfusion algorithms for automated core calculation on perfusion CT (CTP) are based on variations of deconvolution of the tissue concentration time curve with the arterial input function (single value decomposition, or SVD). In this study, we compared ischemic core estimated by two different CTP automated algorithms to the final infarct volume as demonstrated by follow up diffusion weighted imaging (DWI). Methods: We performed a retrospective analysis of patients who underwent EVT. Inclusion criteria were CT perfusion scan prior to EVT, successful EVT with mTICI 2b-3 reperfusion, and DWI scan 24-48 hours post-EVT. CTP data were processed by two different post-processing algorithms: ‘delay-insensitive’ single value decomposition (DISVD) and delay and dispersion corrected single value decomposition (ddSVD) using the respective commercially available automated CTP software. CTP core volumes from both methods were compared with DWI final infarct volumes using an independent software (MRIcron) for concordance. The agreement between a given algorithm and MRI was estimated using Lin’s concordance coefficient and further investigated using reduced major axis regression. Results: One hundred and three patients who underwent EVT and achieved successful mTICI 2b-3 reperfusion were included. Both algorithms had excellent agreement with MRI (Lin’s concordance coefficients: DISVD 0.8 (95% CI: 0.73; 0.87), ddSVD 0.92 (95% CI: 0.89; 0.95). Compared to ddSVD (reduced major axis slope = 0.95), DISVD exhibited larger extent of proportional bias (slope = 1.12). Conclusion: Both algorithms showed excellent agreement with FIV calculated on MRI but DISVD post-processing overestimated the larger ischemic cores, which may lead to unnecessary exclusion of patients from EVT due to a 'large core'.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.51.suppl_1.WP30
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 80381-9
    detail.hit.zdb_id: 1467823-8
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  • 3
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    In Vitro Dengue Virus Inhibition by Aqueous Extracts of Aegle marmelos , Munronia pinnata and Psidium guajava
    SAGE Publications ; 2023
    In:  Alternatives to Laboratory Animals Vol. 51, No. 2 ( 2023-03), p. 136-143
    Details
    In: Alternatives to Laboratory Animals, SAGE Publications, Vol. 51, No. 2 ( 2023-03), p. 136-143
    Abstract: Dengue is an arboviral (insect-transmitted) infection of global concern. Currently, there are still no specific dengue antiviral agents to treat the disease. Plant extracts have been used in traditional medicine for treating various viral infections — thus, in the present study, aqueous extracts of dried flowers of Aegle marmelos (AM), whole plant of Munronia pinnata (MP) and leaves of Psidium guajava (PG) were investigated for their potential capacity to inhibit dengue virus infection of Vero cells. The maximum non-toxic dose (MNTD) and the 50% cytotoxic concentration (CC 50 ) were determined by using the MTT assay. A plaque reduction antiviral assay was carried out with dengue virus types 1 (DV1), 2 (DV2), 3 (DV3) and 4 (DV4), in order to calculate the half-maximum inhibitory concentration (IC 50 ). AM extract inhibited all four virus serotypes tested; MP extract inhibited DV1, DV2 and DV4, but not DV3; PG extract inhibited DV1, DV2 and DV4, but not DV3. Thus, the results suggest that AM is a promising candidate for the pan-serotype inhibition of dengue viral activity.
    Type of Medium: Online Resource
    ISSN: 0261-1929 , 2632-3559
    URL: Article
    DOI: 10.1177/02611929231158243
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
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    SSG: 12,22
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  • 4
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    Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study
    Wiley ; 2023
    In:  CNS Neuroscience & Therapeutics Vol. 29, No. 8 ( 2023-08), p. 2171-2176
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 29, No. 8 ( 2023-08), p. 2171-2176
    Abstract: Untreated basilar artery occlusion (BAO) carries 70% mortality. Guidelines recommend thrombectomy with or without thrombolysis. Aim We compared Modified Rankin Scores (mRS) at 3 and 12 months post thrombectomy to determine benefit of long‐term follow up. Methods Retrospective, single centre analysis of BAO thrombectomies between 2015 and 2019. Inclusion criteria were symptomatic BAO on CT angiography, absent early ischemic changes, premorbid independence and intervention within 24 h. All received stroke ward care. Results were analysed with simple statistics and binary logistic regression as appropriate. Results Of 82 patients: most were male (61%, 50/82) with median age 68 years (IQR 17 years) and median NIHSS 14 (IQR 15). Median door‐to‐puncture time was 42 min (IQR 72 min). Total deaths were 34.1% (28/82) at 3 months, and 37.8% (31/82) at 12 months. Of 51 patients alive at 12 months: 41% (21/51) had improved mRS, 16% (8/51) had worse mRS and 43% (22/51) had unchanged mRS, compared to 3 months. Improvements to mRS were: one point in 57.1% (14/21), two points in 28.9% (6/21) and three points in 4.8% (1/21). Nursing home admission was avoided in 11.8% (6/51) who improved from mRS4. Increased age was associated with decreased likelihood of reaching the primary outcome OR 0.87, 95% CI 0.76–0.99 ( p value = 0.03). Conclusion Over a quarter of patients improved beyond 3 months. Future studies should adopt long‐term follow up as primary outcome.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Article
    DOI: 10.1111/cns.14182
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2423467-9
    detail.hit.zdb_id: 2423461-8
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  • 5
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    Online Resource
    Vaccine Hesitancy during the Coronavirus Pandemic—Lessons from Polio
    MDPI AG ; 2021
    In:  Life Vol. 11, No. 11 ( 2021-11-09), p. 1207-
    Details
    In: Life, MDPI AG, Vol. 11, No. 11 ( 2021-11-09), p. 1207-
    Abstract: The COVID-19 pandemic continues to cause disruptions to families, businesses and healthcare systems globally [...]
    Type of Medium: Online Resource
    ISSN: 2075-1729
    URL: Article
    DOI: 10.3390/life11111207
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662250-6
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  • 6
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    Automated estimation of ischemic core prior to thrombectomy: comparison of two current algorithms
    Springer Science and Business Media LLC ; 2021
    In:  Neuroradiology Vol. 63, No. 10 ( 2021-10), p. 1645-1649
    Details
    In: Neuroradiology, Springer Science and Business Media LLC, Vol. 63, No. 10 ( 2021-10), p. 1645-1649
    Type of Medium: Online Resource
    ISSN: 0028-3940 , 1432-1920
    URL: Article
    DOI: 10.1007/s00234-021-02651-9
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 123305-1
    detail.hit.zdb_id: 1462953-7
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  • 7
    Online Resource
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    Overuse of opioids for acute migraine in an Australian emergency department
    Wiley ; 2020
    In:  Emergency Medicine Australasia Vol. 32, No. 5 ( 2020-10), p. 763-768
    Details
    In: Emergency Medicine Australasia, Wiley, Vol. 32, No. 5 ( 2020-10), p. 763-768
    Abstract: Acute migraine is associated with significant personal, economic and work‐related disability. Management guidelines advise the use of simple analgesia, triptans, chlorpromazine and anti‐emetics based on severity, with avoidance of opioids. We aimed to determine consistency of prescribing patterns in our ED with national guidelines. Methods We performed a retrospective cohort analysis of migraine presentations (ICD‐10‐AM G439) between 2012 and 2016. Exclusion criteria included migraine without headache, other primary headaches and secondary headaches. Demographic and prescribing data were extracted from medical records. Results have been reported as proportions. Results Of 4769 headache presentations, the application of exclusion criteria led to a total of 744 patients who received a migraine diagnosis (G439). Most were female (558/744, 75%), young (mean age 36.4 years) and had a self‐reported migraine history (558/744, 75%). There were 54 different medications prescribed. Paracetamol was more frequently prescribed (385/744, 52%) than aspirin (134/744, 18%). Opioid prescription occurred in nearly half of all presentations (345/744, 46%). Similar opioid prescriptions were also observed in those with a documented history of migraines (253/558, 45%). A minority of patients received triptans (51/744, 7%). Overall, a quarter of patients (189/744, 25%) received no guideline‐recommended medications. Conclusion We observed considerable polypharmacy in ED migraine management with inconsistent prescribing patterns. Recommended medications were infrequently used and opioid use was common. Factors influencing prescribing patterns require further investigation in order to improve rates of guideline recommended treatment.
    Type of Medium: Online Resource
    ISSN: 1742-6731 , 1742-6723
    URL: Issue
    URL: Article
    DOI: 10.1111/emm.v32.5
    DOI: 10.1111/1742-6723.13504
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1502447-7
    detail.hit.zdb_id: 2161824-0
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  • 8
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    018 Management of migraine in the australian emergency department
    BMJ ; 2018
    In:  Journal of Neurology, Neurosurgery & Psychiatry Vol. 89, No. 6 ( 2018-06), p. A8.2-A9
    Details
    In: Journal of Neurology, Neurosurgery & Psychiatry, BMJ, Vol. 89, No. 6 ( 2018-06), p. A8.2-A9
    Abstract: Acute migraine commonly causes significant personal, economic and work-related disability. Australian guidelines recommend treating mild migraine with aspirin and metoclopramide, and moderate-severe migraine with prochlorperazine, chlorpromazine or sumatriptan. Stratified treatment based on severity is preferred to step-wise treatment. Australian data regarding Emergency Department (ED) migraine treatment are scarce. We evaluated prescribing patterns at a Melbourne hospital against national guidelines. Methods Retrospective cohort study of migraine (G439 ICD-10-AM) between 2012–2016. Exclusion criteria included migraine without headache, other primary headaches and secondary headaches. Demographic and prescribing data were extracted from medical records. Proportions were calculated with 95% confidence intervals using Wilson’s method. Comparisons were made between groups using Mann-Whitney and Chi-square tests. Results Of 214,932 ED presentations, 744 with headache presentation received a G439 diagnosis. Most were female (75%; 558/744), young (mean age 34±13 years) and self-reported migraine history (75%; 558/744). There were 55 different medications prescribed. Paracetamol was more frequently prescribed (52%; 385/744) than aspirin (10.6%; 78/744). Opioid prescription occurred in 46% (345/744), single opioid 36% (267/744), 〉 1 opioid 10% (78/744). Median time-to-discharge was 38 min longer with opioid prescription compared with no opioid (222; IQR 164–309 vs 184; 122–258; p 〈 0.01). Just 6.85% (51/744) received triptans. Other treatments were prochlorperazine (14%; 97/744), metoclopramide (38%; 286/744) and chlorpromazine (44%; 3 25/744). Overall, 25.4% (189/744) received no guideline-recommended medication. Conclusion We observed considerable polypharmacy in ED migraine management with inconsistent prescribing patterns. Recommended medications are infrequently used. Opioid use is common and associated with increased time-to-discharge. Failure of ED staff to follow guidelines is unexplained, and requires further investigation.
    Type of Medium: Online Resource
    ISSN: 0022-3050 , 1468-330X
    URL: Article
    DOI: 10.1136/jnnp-2018-ANZAN.18
    RVK:
    XA 10000
    Language: English
    Publisher: BMJ
    Publication Date: 2018
    detail.hit.zdb_id: 1480429-3
    detail.hit.zdb_id: 3087-9
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  • 9
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    Data_Sheet_1.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Neurology Vol. 13 ( 2022-11-3)
    Details
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 13 ( 2022-11-3)
    Abstract: To assess the prevalence and burden of autonomic symptoms in migraine, and determine the relationship with migraine frequency. Background Autonomic symptoms in migraine have been theorized to occur in the setting of inter-ictal sympathetic hypoactivity and hyper-sensitivity. There is limited data prospectively assessing cranial and extra-cranial autonomic symptoms with a validated instrument, or longitudinal data on the relationship between migraine disease activity and autonomic symptoms. Methods Patients attending a single tertiary academic center were recruited into a prospective cohort study between September 2020 and June 2022. In addition to standard clinical care, they completed several surveys including the Composite Autonomic Symptom Scale (COMPASS-31) questionnaire, a validated survey of autonomic symptoms. Results A total of 43 patients (66.7% female, median age 42, IQR 17) were included in the final analysis. There was a baseline 20 monthly headache days (MHD) (IQR 21.7), and 65.1% of the population had chronic migraine by ICHD-3 criteria. A significantly elevated weighted COMPASS-31 score was reported in 60.5% of respondents (mean 30.3, SD 13.3) at baseline. After 12 months treatment, significant improvements were reported in migraine frequency (median MHD 20–8.7) and disability (median Migraine Disability Assessment Score 67–48), but not in autonomic symptoms (mean score 30.3, SD 11.2). Conclusion Autonomic symptoms were frequently reported in patients with migraine. However, they did not correlate with headache frequency or reversion to episodic frequency. Further study is required to elucidate specific approaches and treatments for autonomic symptoms, and further evaluate the underlying pathophysiological mechanisms.
    Type of Medium: Online Resource
    ISSN: 1664-2295
    URL: Article
    URL: Article
    DOI: 10.3389/fneur.2022.1036798
    DOI: 10.3389/fneur.2022.1036798.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564214-5
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