In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 5 ( 2022-5-31), p. e0267706-
Abstract:
Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary osteoporosis, alendronate (ALE) and teriparatide (TPTD) are widely used in the treatment of GIOP. However, which of these two drugs has a better curative effect needs the support of evidence-based medicine. Methods We searched PubMed, Embase, Cochrane Library, Web of Science, and Google Scholar for randomized controlled trials of ALE and TPTD in the treatment of glucocorticoid-induced osteoporosis until February 2022. These patients included in the study took glucocorticoid doses greater than 7.5 mg/d for more than 3 months before treatment with ALE and TPTD. The risk ratio (RR) and its 95% confidence interval (CI) are used as the influence index of discontinuous data, and the standardized mean difference (SMD) and its 95% CI are used as the influence index of continuous data. Results A total of 4102 patients were enrolled in all 5 studies that met the admission criteria. We found that compared with ALE, TPTD could reduce the rate of new vertebral fracture (RR = 0.13, 95% CI: 0.05–0.34, P 〈 0.00001). TPTD increased LS bone mineral density (BMD) (0.53, 95% CI 0.42–0.64, P 〈 0.00001), TH BMD (0.17, 95% CI 0.05–0.28, P = 0.004) and FN BMD (0.17, 95% CI 0.05–0.29, P = 0.006) compared to ALE. However, there was no significant difference in the incidence of non-vertebral fracture and adverse events between the two groups. Conclusions Compared with ALE, TPTD is an effective drug to reduce vertebral fracture risk in patients with GIOP. Furthermore, long-term use of TPTD can increase the bone mineral density of LS, FN, and TH.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0267706
DOI:
10.1371/journal.pone.0267706.g001
DOI:
10.1371/journal.pone.0267706.g002
DOI:
10.1371/journal.pone.0267706.g003
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10.1371/journal.pone.0267706.g004
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10.1371/journal.pone.0267706.g005
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10.1371/journal.pone.0267706.g006
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10.1371/journal.pone.0267706.g007
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10.1371/journal.pone.0267706.g008
DOI:
10.1371/journal.pone.0267706.g009
DOI:
10.1371/journal.pone.0267706.g010
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10.1371/journal.pone.0267706.g011
DOI:
10.1371/journal.pone.0267706.t001
DOI:
10.1371/journal.pone.0267706.s001
DOI:
10.1371/journal.pone.0267706.s002
DOI:
10.1371/journal.pone.0267706.s003
DOI:
10.1371/journal.pone.0267706.s004
DOI:
10.1371/journal.pone.0267706.r001
DOI:
10.1371/journal.pone.0267706.r002
DOI:
10.1371/journal.pone.0267706.r003
DOI:
10.1371/journal.pone.0267706.r004
DOI:
10.1371/journal.pone.0267706.r005
DOI:
10.1371/journal.pone.0267706.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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